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Items: 1 to 20 of 52


Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice.

Yeh CW, Liu HK, Lin LC, Liou KT, Huang YC, Lin CH, Tzeng TT, Shie FS, Tsay HJ, Shiao YJ.

J Ethnopharmacol. 2017 Sep 14;209:50-61. doi: 10.1016/j.jep.2017.07.036. Epub 2017 Jul 22.


Obesity Accelerates Alzheimer-Related Pathology in <i>APOE4</i> but not <i>APOE3</i> Mice.

Moser VA, Pike CJ.

eNeuro. 2017 Jun 13;4(3). pii: ENEURO.0077-17.2017. doi: 10.1523/ENEURO.0077-17.2017. eCollection 2017 May-Jun.


Considering sex and gender in Alzheimer disease and other dementias.

Podcasy JL, Epperson CN.

Dialogues Clin Neurosci. 2016 Dec;18(4):437-446. Review.


c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice.

Wu R, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W, Yuan Z.

Diabetologia. 2017 May;60(5):900-910. doi: 10.1007/s00125-016-4202-2. Epub 2017 Jan 10.


Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes.

McLimans KE, Willette AA; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2017;56(1):403-413. doi: 10.3233/JAD-160891.


Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.

Int J Mol Sci. 2016 Sep 7;17(9). pii: E1495. doi: 10.3390/ijms17091495. Review.


Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer's Disease Stage in APP/PS1 Mice.

Ettcheto M, Petrov D, Pedrós I, Alva N, Carbonell T, Beas-Zarate C, Pallas M, Auladell C, Folch J, Camins A.

J Alzheimers Dis. 2016 Jul 14;54(1):233-51. doi: 10.3233/JAD-160150.


Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults.

Daily JW, Park S.

Nutrition. 2017 Jan;33:187-194. doi: 10.1016/j.nut.2016.07.001. Epub 2016 Jul 26.


SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE.

J Clin Invest. 2016 Jul 1;126(7):2706-20. doi: 10.1172/JCI84708. Epub 2016 Jun 20.


Impaired macrophage autophagy induces systemic insulin resistance in obesity.

Kang YH, Cho MH, Kim JY, Kwon MS, Peak JJ, Kang SW, Yoon SY, Song Y.

Oncotarget. 2016 Jun 14;7(24):35577-35591. doi: 10.18632/oncotarget.9590.


Neuronal human BACE1 knockin induces systemic diabetes in mice.

Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield PD, Doherty MK, Mingarelli M, Welch A, Riedel G, Delibegovic M, Platt B.

Diabetologia. 2016 Jul;59(7):1513-1523. doi: 10.1007/s00125-016-3960-1. Epub 2016 May 2.


Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC.

Cell. 2016 May 5;165(4):882-95. doi: 10.1016/j.cell.2016.03.033. Epub 2016 Apr 28. Erratum in: Cell. 2016 Aug 25;166(5):1338-1340.


Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels.

Ruiz HH, Chi T, Shin AC, Lindtner C, Hsieh W, Ehrlich M, Gandy S, Buettner C.

Alzheimers Dement. 2016 Aug;12(8):851-61. doi: 10.1016/j.jalz.2016.01.008. Epub 2016 Feb 28.


Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S.

Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.


Non-alcoholic fatty liver disease induces signs of Alzheimer's disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model.

Kim DG, Krenz A, Toussaint LE, Maurer KJ, Robinson SA, Yan A, Torres L, Bynoe MS.

J Neuroinflammation. 2016 Jan 5;13:1. doi: 10.1186/s12974-015-0467-5.


The Emerging Role of MitomiRs in the Pathophysiology of Human Disease.

Duarte FV, Palmeira CM, Rolo AP.

Adv Exp Med Biol. 2015;888:123-54. doi: 10.1007/978-3-319-22671-2_8.


High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A.

PLoS One. 2015 Sep 28;10(9):e0131199. doi: 10.1371/journal.pone.0131199. eCollection 2015.


Down syndrome--genetic and nutritional aspects of accompanying disorders.

Mazurek D, Wyka J.

Rocz Panstw Zakl Hig. 2015;66(3):189-94. Review.


Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice.

Shie FS, Shiao YJ, Yeh CW, Lin CH, Tzeng TT, Hsu HC, Huang FL, Tsay HJ, Liu HK.

PLoS One. 2015 Aug 5;10(8):e0134531. doi: 10.1371/journal.pone.0134531. eCollection 2015.

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