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Best matches for alzheimer's tlr2:

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. Liu S et al. J Immunol. (2012)

Microglial Aβ receptors in Alzheimer's disease. Yu Y et al. Cell Mol Neurobiol. (2015)

Toll-like receptors in Alzheimer's disease: a therapeutic perspective. Gambuzza ME et al. CNS Neurol Disord Drug Targets. (2014)

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Items: 1 to 20 of 70


Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer's disease.

Heshmati-Fakhr N, Sotoodehnejadnematalahi F, Yousefi N, Sayyah M, Hosseini SM, Pourbadie HG.

Neuroreport. 2018 Sep 14. doi: 10.1097/WNR.0000000000001132. [Epub ahead of print]


Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid.

Rubio-Araiz A, Finucane OM, Keogh S, Lynch MA.

J Neuroinflammation. 2018 Aug 31;15(1):247. doi: 10.1186/s12974-018-1281-7.


High-Mobility Group Box 1 (HMGB1), an Endogenous Ligand of Toll-Like Receptors 2 and 4, Induces Astroglial Inflammation via NF-ҡβ Pathway.

Al-Ofi EA, Al-Ghamdi BS.

Folia Morphol (Warsz). 2018 Aug 14. doi: 10.5603/FM.a2018.0068. [Epub ahead of print]


The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice.

Garcez ML, Mina F, Bellettini-Santos T, da Luz AP, Schiavo GL, Macieski JMC, Medeiros EB, Marques AO, Magnus NQ, Budni J.

Mol Neurobiol. 2018 Jul 26. doi: 10.1007/s12035-018-1211-9. [Epub ahead of print]


Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease-related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence.

Pourbadie HG, Sayyah M, Khoshkholgh-Sima B, Choopani S, Nategh M, Motamedi F, Shokrgozar MA.

Neurobiol Aging. 2018 Oct;70:203-216. doi: 10.1016/j.neurobiolaging.2018.06.020. Epub 2018 Jun 28.


Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.

Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K.

J Clin Invest. 2018 Sep 4. pii: 96209. doi: 10.1172/JCI96209. [Epub ahead of print]


Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting the TLR/NF-κB Pathway.

Li B, Xu P, Wu S, Jiang Z, Huang Z, Li Q, Chen D.

J Alzheimers Dis. 2018;64(3):943-955. doi: 10.3233/JAD-180330.


Dangguishaoyao-San attenuates LPS-induced neuroinflammation via the TLRs/NF-κB signaling pathway.

Ding RR, Chen W, Guo CY, Liao WT, Yang X, Liao FE, Lin JM, Mei HF, Zeng Y.

Biomed Pharmacother. 2018 Sep;105:187-194. doi: 10.1016/j.biopha.2018.05.108. Epub 2018 May 29.


Serum amyloid A primes microglia for ATP-dependent interleukin-1β release.

Facci L, Barbierato M, Zusso M, Skaper SD, Giusti P.

J Neuroinflammation. 2018 May 26;15(1):164. doi: 10.1186/s12974-018-1205-6.


Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI.

Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8.


CXCR4 involvement in neurodegenerative diseases.

Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP).

Transl Psychiatry. 2018 Apr 11;8(1):73. doi: 10.1038/s41398-017-0049-7.


Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer's Disease Brain: A Review.

Zhan X, Stamova B, Sharp FR.

Front Aging Neurosci. 2018 Feb 22;10:42. doi: 10.3389/fnagi.2018.00042. eCollection 2018. Review.


Xanthoceraside attenuates amyloid β peptide1-42-induced memory impairments by reducing neuroinflammatory responses in mice.

Qi Y, Ji XF, Chi TY, Liu P, Jin G, Xu Q, Jiao Q, Wang LH, Zou LB.

Eur J Pharmacol. 2018 Feb 5;820:18-30. doi: 10.1016/j.ejphar.2017.11.045. Epub 2017 Dec 8.


Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.

Nam KN, Wolfe CM, Fitz NF, Letronne F, Castranio EL, Mounier A, Schug J, Lefterov I, Koldamova R.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):152-161. doi: 10.1016/j.bbadis.2017.10.018. Epub 2017 Oct 14.


Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation.

Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.

Front Aging Neurosci. 2017 Aug 31;9:277. doi: 10.3389/fnagi.2017.00277. eCollection 2017.


IRF-8 is Involved in Amyloid-β1-40 (Aβ1-40)-induced Microglial Activation: a New Implication in Alzheimer's Disease.

Zeng Q, Man R, Luo Y, Zeng L, Zhong Y, Lu B, Wang X.

J Mol Neurosci. 2017 Oct;63(2):159-164. doi: 10.1007/s12031-017-0966-1. Epub 2017 Aug 31.


Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients.

Le Page A, Lamoureux J, Bourgade K, Frost EH, Pawelec G, Witkowski JM, Larbi A, Dupuis G, Fülöp T.

J Alzheimers Dis. 2017;60(1):23-42. doi: 10.3233/JAD-170124.


Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice.

Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P, Nakanishi H.

Brain Behav Immun. 2017 Oct;65:350-361. doi: 10.1016/j.bbi.2017.06.002. Epub 2017 Jun 10.


Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway.

Koo JH, Jang YC, Hwang DJ, Um HS, Lee NH, Jung JH, Cho JY.

Neuroscience. 2017 Jul 25;356:102-113. doi: 10.1016/j.neuroscience.2017.05.016. Epub 2017 May 18.


Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.

McRobb LS, McKay MJ, Gamble JR, Grace M, Moutrie V, Santos ED, Lee VS, Zhao Z, Molloy MP, Stoodley MA.

Aging (Albany NY). 2017 Apr;9(4):1248-1268. doi: 10.18632/aging.101225.

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