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Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model.

Dhivya Bharathi M, Justin-Thenmozhi A, Manivasagam T, Ahmad Rather M, Saravana Babu C, Mohamed Essa M, Guillemin GJ.

Neurotox Res. 2018 Sep 21. doi: 10.1007/s12640-018-9956-5. [Epub ahead of print]


PKR modulates abnormal brain signaling in experimental obesity.

Taga M, Mouton-Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, Thomasseau S, Paquet C, Nicoll JAR, Boche D, Hugon J.

PLoS One. 2018 May 24;13(5):e0196983. doi: 10.1371/journal.pone.0196983. eCollection 2018.


Could ryanodine receptor dysfunction be linked to PKR brain accumulations in Alzheimer's disease?

Hugon J, Paquet C.

Med Hypotheses. 2018 Apr;113:45. doi: 10.1016/j.mehy.2018.02.012. Epub 2018 Feb 19. No abstract available.


Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition.

Hwang KD, Bak MS, Kim SJ, Rhee S, Lee YS.

Mol Brain. 2017 Dec 13;10(1):57. doi: 10.1186/s13041-017-0338-3.


PKR involvement in Alzheimer's disease.

Hugon J, Mouton-Liger F, Dumurgier J, Paquet C.

Alzheimers Res Ther. 2017 Oct 5;9(1):83. doi: 10.1186/s13195-017-0308-0. Review.


Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.

Yan L, Deng Y, Gao J, Liu Y, Li F, Shi J, Gong Q.

Front Pharmacol. 2017 Mar 8;8:106. doi: 10.3389/fphar.2017.00106. eCollection 2017.


Evaluation of human microtubule affinity-regulating kinase 4 inhibitors: fluorescence binding studies, enzyme, and cell assays.

Naz F, Sami N, Naqvi AT, Islam A, Ahmad F, Imtaiyaz Hassan M.

J Biomol Struct Dyn. 2017 Nov;35(14):3194-3203. doi: 10.1080/07391102.2016.1249958. Epub 2016 Nov 3.


Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity.

Gourmaud S, Mouton-Liger F, Abadie C, Meurs EF, Paquet C, Hugon J.

J Alzheimers Dis. 2016 Oct 18;54(4):1659-1670.


Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll JA, Hugon J, Boche D; MRC CFAS.

Brain Pathol. 2017 May;27(3):266-275. doi: 10.1111/bpa.12388. Epub 2016 Jun 8.


Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer's disease.

Zhang JS, Zhou SF, Wang Q, Guo JN, Liang HM, Deng JB, He WY.

Neuroscience. 2016 Jun 14;325:1-9. doi: 10.1016/j.neuroscience.2016.03.024. Epub 2016 Mar 14.


Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.

Severini C, Lattanzi R, Maftei D, Marconi V, Ciotti MT, Petrocchi Passeri P, Florenzano F, Del Duca E, Caioli S, Zona C, Balboni G, Salvadori S, Nisticò R, Negri L.

Sci Rep. 2015 Oct 19;5:15301. doi: 10.1038/srep15301.


PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice.

Segev Y, Barrera I, Ounallah-Saad H, Wibrand K, Sporild I, Livne A, Rosenberg T, David O, Mints M, Bramham CR, Rosenblum K.

J Neurosci. 2015 Sep 23;35(38):12986-93. doi: 10.1523/JNEUROSCI.5241-14.2015.


Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease.

Paquet C, Dumurgier J, Hugon J.

Front Neurol. 2015 Aug 4;6:168. doi: 10.3389/fneur.2015.00168. eCollection 2015. Review.


Suppression effects of O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress in SK-N-SH cells.

Janyou A, Changtam C, Suksamrarn A, Tocharus C, Tocharus J.

Neurotoxicology. 2015 Sep;50:92-100. doi: 10.1016/j.neuro.2015.08.005. Epub 2015 Aug 8.


Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase.

Bruch J, Kurz C, Vasiljevic A, Nicolino M, Arzberger T, Höglinger GU.

J Neuropathol Exp Neurol. 2015 Aug;74(8):850-7. doi: 10.1097/NEN.0000000000000224.


Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway.

Zhu YF, Li XH, Yuan ZP, Li CY, Tian RB, Jia W, Xiao ZP.

Eur J Pharmacol. 2015 Sep 5;762:239-46. doi: 10.1016/j.ejphar.2015.06.002. Epub 2015 Jun 3.


Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis.

Ill-Raga G, Tajes M, Busquets-García A, Ramos-Fernández E, Vargas LM, Bosch-Morató M, Guivernau B, Valls-Comamala V, Eraso-Pichot A, Guix FX, Fandos C, Rosen MD, Rabinowitz MH, Maldonado R, Alvarez AR, Ozaita A, Muñoz FJ.

Antioxid Redox Signal. 2015 May 20;22(15):1295-307. doi: 10.1089/ars.2014.6080. Epub 2015 Mar 25.


Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.

Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, Mouton-Liger F, Hugon J.

Sci Rep. 2015 Feb 17;5:8489. doi: 10.1038/srep08489.


PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.

Mouton-Liger F, Rebillat AS, Gourmaud S, Paquet C, Leguen A, Dumurgier J, Bernadelli P, Taupin V, Pradier L, Rooney T, Hugon J.

Cell Death Dis. 2015 Jan 15;6:e1594. doi: 10.1038/cddis.2014.552.

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