Format
Sort by
Items per page

Send to

Choose Destination

Best matches for alzheimer's nicastrin:

Nicastrin guards Alzheimer's gate. Urban S et al. Proc Natl Acad Sci U S A. (2016)

ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity. Zhu B et al. Nat Commun. (2017)

An atomic structure of human γ-secretase. Bai XC et al. Nature. (2015)

Search results

Items: 1 to 20 of 323

1.

Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease.

Mirzaei M, Pushpitha K, Deng L, Chitranshi N, Gupta V, Rajput R, Mangani AB, Dheer Y, Godinez A, McKay MJ, Kamath K, Pascovici D, Wu JX, Salekdeh GH, Karl T, Haynes PA, Graham SL, Gupta VK.

Mol Neurobiol. 2019 Feb 1. doi: 10.1007/s12035-019-1479-4. [Epub ahead of print]

PMID:
30707393
2.

γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding.

Hitzenberger M, Zacharias M.

Front Chem. 2019 Jan 4;6:640. doi: 10.3389/fchem.2018.00640. eCollection 2018.

3.

Influence of membrane lipid composition on the structure and activity of γ-secretase.

Aguayo-Ortiz R, Straub JE, Dominguez L.

Phys Chem Chem Phys. 2018 Nov 7;20(43):27294-27304. doi: 10.1039/c8cp04138e.

PMID:
30357233
4.

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.

Imai S, Cai T, Yoshida C, Tomita T, Futai E.

J Biochem. 2019 Jan 1;165(1):37-46. doi: 10.1093/jb/mvy081.

PMID:
30289529
5.

The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration.

Gezen-Ak D, Atasoy İL, Candaş E, Alaylıoğlu M, Dursun E.

Neuromolecular Med. 2018 Sep;20(3):363-375. doi: 10.1007/s12017-018-8498-6. Epub 2018 Jun 12.

PMID:
29948923
6.

Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice.

Yu X, Guan PP, Zhu D, Liang YY, Wang T, Wang ZY, Wang P.

Front Mol Neurosci. 2018 May 30;11:172. doi: 10.3389/fnmol.2018.00172. eCollection 2018.

7.

Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.

Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S.

Biochem Biophys Res Commun. 2018 Jul 7;502(1):98-103. doi: 10.1016/j.bbrc.2018.05.126. Epub 2018 May 25.

PMID:
29787759
8.

Structure of APP-C991-99 and implications for role of extra-membrane domains in function and oligomerization.

Pantelopulos GA, Straub JE, Thirumalai D, Sugita Y.

Biochim Biophys Acta Biomembr. 2018 Apr 24. pii: S0005-2736(18)30112-3. doi: 10.1016/j.bbamem.2018.04.002. [Epub ahead of print]

PMID:
29702072
9.

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells.

Wang Z, Huang X, Zhao P, Zhao L, Wang ZY.

Front Aging Neurosci. 2018 Mar 19;10:66. doi: 10.3389/fnagi.2018.00066. eCollection 2018.

10.

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease.

Nyarko JNK, Quartey MO, Pennington PR, Heistad RM, Dea D, Poirier J, Baker GB, Mousseau DD.

Neuroscience. 2018 Mar 1;373:20-36. doi: 10.1016/j.neuroscience.2018.01.005. Epub 2018 Jan 11.

11.

Allosteric Modulation of Intact γ-Secretase Structural Dynamics.

Lee JY, Feng Z, Xie XQ, Bahar I.

Biophys J. 2017 Dec 19;113(12):2634-2649. doi: 10.1016/j.bpj.2017.10.012.

12.

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

Grimm MOW, Thiel A, Lauer AA, Winkler J, Lehmann J, Regner L, Nelke C, Janitschke D, Benoist C, Streidenberger O, Stötzel H, Endres K, Herr C, Beisswenger C, Grimm HS, Bals R, Lammert F, Hartmann T.

Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. doi: 10.3390/ijms18122764.

13.

ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity.

Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H.

Nat Commun. 2017 Nov 13;8(1):1472. doi: 10.1038/s41467-017-01799-4.

14.

Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane.

Audagnotto M, Kengo Lorkowski A, Dal Peraro M.

Biochem Biophys Res Commun. 2018 Mar 29;498(2):334-341. doi: 10.1016/j.bbrc.2017.10.164. Epub 2017 Oct 31.

PMID:
29097209
15.

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.

Zhou R, Yang G, Shi Y.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12731-12736. doi: 10.1073/pnas.1713605114. Epub 2017 Oct 9.

16.

Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.

Blue EE, Yu CE, Thornton TA, Chapman NH, Kernfeld E, Jiang N, Shively KM, Buckingham KJ, Marvin CT, Bamshad MJ, Bird TD, Wijsman EM.

Genes Brain Behav. 2018 Jul;17(6):e12429. doi: 10.1111/gbb.12429. Epub 2017 Nov 20.

PMID:
29045054
17.

Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases.

Cai Z, Liu Z, Xiao M, Wang C, Tian F.

Neurochem Res. 2017 Dec;42(12):3446-3455. doi: 10.1007/s11064-017-2391-9. Epub 2017 Aug 24.

PMID:
28836062
18.

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.

Sogorb-Esteve A, García-Ayllón MS, Llansola M, Felipo V, Blennow K, Sáez-Valero J.

Mol Neurobiol. 2018 Jun;55(6):5047-5058. doi: 10.1007/s12035-017-0705-1. Epub 2017 Aug 16.

19.

Vitamin D Receptor Regulates Amyloid Beta 1-42 Production with Protein Disulfide Isomerase A3.

Gezen-Ak D, Atasoy IL, Candaş E, Alaylioglu M, Yılmazer S, Dursun E.

ACS Chem Neurosci. 2017 Oct 18;8(10):2335-2346. doi: 10.1021/acschemneuro.7b00245. Epub 2017 Jul 28.

PMID:
28707894
20.

Bidirectional regulation of Aβ levels by Presenilin 1.

Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22.

Supplemental Content

Loading ...
Support Center