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Items: 1 to 20 of 196

1.

BACE2, a conditional β-secretase, contributes to Alzheimer's disease pathogenesis.

Wang Z, Xu Q, Cai F, Liu X, Wu Y, Song W.

JCI Insight. 2019 Jan 10;4(1). pii: 123431. doi: 10.1172/jci.insight.123431. [Epub ahead of print]

2.

BACE2 distribution in major brain cell types and identification of novel substrates.

Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B.

Life Sci Alliance. 2018 Feb 15;1(1):e201800026. doi: 10.26508/lsa.201800026. eCollection 2018 Jan.

3.

Cleavage of potassium channel Kv2.1 by BACE2 reduces neuronal apoptosis.

Liu F, Zhang Y, Liang Z, Sun Q, Liu H, Zhao J, Xu J, Zheng J, Yun Y, Yu X, Song W, Sun X.

Mol Psychiatry. 2018 Jul;23(7):1542-1554. doi: 10.1038/s41380-018-0060-2. Epub 2018 Apr 27.

PMID:
29703946
4.

Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.

Johansson P, Kaspersson K, Gurrell IK, Bäck E, Eketjäll S, Scott CW, Cebers G, Thorne P, McKenzie MJ, Beaton H, Davey P, Kolmodin K, Holenz J, Duggan ME, Budd Haeberlein S, Bürli RW.

J Med Chem. 2018 Apr 26;61(8):3491-3502. doi: 10.1021/acs.jmedchem.7b01716. Epub 2018 Apr 10.

PMID:
29617572
5.

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

O'Neill BT, Beck EM, Butler CR, Nolan CE, Gonzales C, Zhang L, Doran SD, Lapham K, Buzon LM, Dutra JK, Barreiro G, Hou X, Martinez-Alsina LA, Rogers BN, Villalobos A, Murray JC, Ogilvie K, LaChapelle EA, Chang C, Lanyon LF, Steppan CM, Robshaw A, Hales K, Boucher GG, Pandher K, Houle C, Ambroise CW, Karanian D, Riddell D, Bales KR, Brodney MA.

J Med Chem. 2018 May 24;61(10):4476-4504. doi: 10.1021/acs.jmedchem.8b00246. Epub 2018 Apr 17.

PMID:
29613789
6.

Amyloid precursor protein in pancreatic islets.

Kulas JA, Puig KL, Combs CK.

J Endocrinol. 2017 Oct;235(1):49-67. doi: 10.1530/JOE-17-0122. Epub 2017 Jul 14.

7.

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2.

Yan R.

Front Mol Neurosci. 2017 Apr 19;10:97. doi: 10.3389/fnmol.2017.00097. eCollection 2017. Review.

8.

BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.

Alcarraz-Vizán G, Castaño C, Visa M, Montane J, Servitja JM, Novials A.

Cell Mol Life Sci. 2017 Aug;74(15):2827-2838. doi: 10.1007/s00018-017-2505-1. Epub 2017 Mar 23.

PMID:
28337562
9.

Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer's Disease Type Pathology in vitro.

Dashinimaev EB, Artyuhov AS, Bolshakov AP, Vorotelyak EA, Vasiliev AV.

J Alzheimers Dis. 2017;56(2):835-847. doi: 10.3233/JAD-160945.

PMID:
28059787
10.

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.

Scott JD, Li SW, Brunskill AP, Chen X, Cox K, Cumming JN, Forman M, Gilbert EJ, Hodgson RA, Hyde LA, Jiang Q, Iserloh U, Kazakevich I, Kuvelkar R, Mei H, Meredith J, Misiaszek J, Orth P, Rossiter LM, Slater M, Stone J, Strickland CO, Voigt JH, Wang G, Wang H, Wu Y, Greenlee WJ, Parker EM, Kennedy ME, Stamford AW.

J Med Chem. 2016 Dec 8;59(23):10435-10450. Epub 2016 Nov 18.

PMID:
27933948
11.
12.

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations.

Hernández-Rodríguez M, Correa-Basurto J, Gutiérrez A, Vitorica J, Rosales-Hernández MC.

Eur J Med Chem. 2016 Nov 29;124:1142-1154. doi: 10.1016/j.ejmech.2016.08.028. Epub 2016 Aug 16.

PMID:
27639619
13.

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF.

Mol Neurodegener. 2016 Oct 5;11(1):67.

14.

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

Shimshek DR, Jacobson LH, Kolly C, Zamurovic N, Balavenkatraman KK, Morawiec L, Kreutzer R, Schelle J, Jucker M, Bertschi B, Theil D, Heier A, Bigot K, Beltz K, Machauer R, Brzak I, Perrot L, Neumann U.

Sci Rep. 2016 Feb 25;6:21917. doi: 10.1038/srep21917.

15.

Germinated Brown Rice Alters Aβ(1-42) Aggregation and Modulates Alzheimer's Disease-Related Genes in Differentiated Human SH-SY5Y Cells.

Azmi NH, Ismail M, Ismail N, Imam MU, Alitheen NB, Abdullah MA.

Evid Based Complement Alternat Med. 2015;2015:153684. doi: 10.1155/2015/153684. Epub 2015 Dec 22.

16.

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.

Rulifson IC, Cao P, Miao L, Kopecky D, Huang L, White RD, Samayoa K, Gardner J, Wu X, Chen K, Tsuruda T, Homann O, Baribault H, Yamane H, Carlson T, Wiltzius J, Li Y.

PLoS One. 2016 Feb 3;11(2):e0147254. doi: 10.1371/journal.pone.0147254. eCollection 2016.

17.

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Barão S, Moechars D, Lichtenthaler SF, De Strooper B.

Trends Neurosci. 2016 Mar;39(3):158-169. doi: 10.1016/j.tins.2016.01.003. Epub 2016 Jan 30. Review.

PMID:
26833257
18.

A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility.

Kumalo HM, Soliman ME.

J Recept Signal Transduct Res. 2016 Oct;36(5):505-14. doi: 10.3109/10799893.2015.1130058. Epub 2016 Jan 24.

PMID:
26804314
19.

Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.

Lange J, Lunde KA, Sletten C, Møller SG, Tysnes OB, Alves G, Larsen JP, Maple-Grødem J.

Parkinsons Dis. 2015;2015:973298. doi: 10.1155/2015/973298. Epub 2015 Dec 14.

20.

Reversible and Species-Specific Depigmentation Effects of AZD3293, a BACE Inhibitor for the Treatment of Alzheimer's Disease, Are Related to BACE2 Inhibition and Confined to Epidermis and Hair.

Cebers G, Lejeune T, Attalla B, Soderberg M, Alexander RC, Budd Haeberlein S, Kugler AR, Ingersoll EW, Platz S, Scott CW.

J Prev Alzheimers Dis. 2016;3(4):202-218. doi: 10.14283/jpad.2016.119.

PMID:
29199322

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