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Best matches for alzheimer's bace1:

Targeting the β secretase BACE1 for Alzheimer's disease therapy. Yan R et al. Lancet Neurol. (2014)

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease. Ghosh AK et al. Chem Soc Rev. (2014)

BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Vassar R et al. Alzheimers Res Ther. (2014)

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Items: 1 to 20 of 2546


K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression.

Choi JY, Yeo IJ, Kim KC, Choi WR, Jung JK, Han SB, Hong JT.

J Neuroinflammation. 2018 Aug 11;15(1):224. doi: 10.1186/s12974-018-1269-3.


BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines.

Blume T, Filser S, Jaworska A, Blain JF, Koenig G, Moschke K, Lichtenthaler SF, Herms J.

Front Aging Neurosci. 2018 Jul 26;10:229. doi: 10.3389/fnagi.2018.00229. eCollection 2018.


Polypharmacology of Berberine Based on Multi-Target Binding Motifs.

Chu M, Chen X, Wang J, Guo L, Wang Q, Gao Z, Kang J, Zhang M, Feng J, Guo Q, Li B, Zhang C, Guo X, Chu Z, Wang Y.

Front Pharmacol. 2018 Jul 24;9:801. doi: 10.3389/fphar.2018.00801. eCollection 2018.


TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.

Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.

PLoS One. 2018 Aug 7;13(8):e0200988. doi: 10.1371/journal.pone.0200988. eCollection 2018.


BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice.

Chatila ZK, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram MK, Gupta D, Kwak SS, Kim YH, Kim DY, Choi SH, Tanzi RE.

eNeuro. 2018 Aug 3;5(4). pii: ENEURO.0067-18.2018. doi: 10.1523/ENEURO.0067-18.2018. eCollection 2018 Jul-Aug.


A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes.

Hu M, Zhang J, Yang J, Cao Y, Qi J.

J Mol Neurosci. 2018 Jul 31. doi: 10.1007/s12031-018-1139-6. [Epub ahead of print]


Early evidence of stress in immortalized neurons exposed to diesel particles: the role of lipid reshaping behind oxidative stress and inflammation.

Milani C, Corsetto PA, Farina F, Botto L, Lonati E, Massimino L, Rizzo AM, Bulbarelli A, Palestini P.

Toxicology. 2018 Jul 25;409:63-72. doi: 10.1016/j.tox.2018.07.017. [Epub ahead of print]


Kinetics and molecular docking of dihydroxanthyletin-type coumarins from Angelica decursiva that inhibit cholinesterase and BACE1.

Ali MY, Seong SH, Jung HA, Jannat S, Choi JS.

Arch Pharm Res. 2018 Jul;41(7):753-764. doi: 10.1007/s12272-018-1056-9. Epub 2018 Jul 25.


Investigation of Intermolecular interactions and Stability of Verubecestat in the active site of BACE1: Development of First model from QM/MM based Charge density and MD Analysis.

Kandasamy S, Magudeeswaran S, Govindasamy H, Lakshmanan M, Poomani K.

J Biomol Struct Dyn. 2018 Jul 25:1-43. doi: 10.1080/07391102.2018.1479661. [Epub ahead of print]


The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage.

Jiang C, Zou X, Zhu R, Shi Y, Wu Z, Zhao F, Chen L.

J Neurosurg. 2018 Jul 20:1-10. doi: 10.3171/2018.1.JNS172938. [Epub ahead of print]


Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.

Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E.

Biochim Biophys Acta. 2018 Jul 5. pii: S0925-4439(18)30233-3. doi: 10.1016/j.bbadis.2018.07.005. [Epub ahead of print]


BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S.

PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018.


Identification of the biological affection of long noncoding RNA BC200 in Alzheimer's disease.

Li H, Zheng L, Jiang A, Mo Y, Gong Q.

Neuroreport. 2018 Sep 5;29(13):1061-1067. doi: 10.1097/WNR.0000000000001057.


Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.

Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD.

Bioorg Med Chem Lett. 2018 Aug 15;28(15):2605-2610. doi: 10.1016/j.bmcl.2018.06.045. Epub 2018 Jun 26.


Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice via inhibiting β/γ-secretases activity and enhancing α-secretases.

Cai Z, Wang C, He W, Chen Y.

Curr Alzheimer Res. 2018 Jul 1. doi: 10.2174/1567205015666180702105740. [Epub ahead of print]


miR-15b Reduces Amyloid-β Accumulation in SH-SY5Y Cell Line through Targeting NF-κB signaling and BACE1.

Li J, Wang H.

Biosci Rep. 2018 Jul 1. pii: BSR20180051. doi: 10.1042/BSR20180051. [Epub ahead of print]


Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.

Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G.

Biomed Pharmacother. 2018 Jun 25;106:92-97. doi: 10.1016/j.biopha.2018.06.106. [Epub ahead of print]


Clinical Research on Alzheimer's Disease: Progress and Perspectives.

Sun BL, Li WW, Zhu C, Jin WS, Zeng F, Liu YH, Bu XL, Zhu J, Yao XQ, Wang YJ.

Neurosci Bull. 2018 Jun 28. doi: 10.1007/s12264-018-0249-z. [Epub ahead of print] Review.


Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease.

Frontiñán-Rubio J, Sancho-Bielsa FJ, Peinado JR, LaFerla FM, Giménez-Llort L, Durán-Prado M, Alcain FJ.

Mol Cell Neurosci. 2018 Jun 25;92:67-81. doi: 10.1016/j.mcn.2018.06.005. [Epub ahead of print]


Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement.

Corpas R, Griñán-Ferré C, Rodríguez-Farré E, Pallàs M, Sanfeliu C.

Mol Neurobiol. 2018 Jun 13. doi: 10.1007/s12035-018-1157-y. [Epub ahead of print]


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