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Items: 16

1.

miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease.

Li J, Chen W, Yi Y, Tong Q.

J Cell Biochem. 2018 Dec 16. doi: 10.1002/jcb.28276. [Epub ahead of print]

PMID:
30556160
2.

Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases.

Nozal V, Martinez A.

Eur J Med Chem. 2019 Jan 1;161:39-47. doi: 10.1016/j.ejmech.2018.10.030. Epub 2018 Oct 15. Review.

PMID:
30342424
3.

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.

Taylor LM, McMillan PJ, Liachko NF, Strovas TJ, Ghetti B, Bird TD, Keene CD, Kraemer BC.

Mol Neurodegener. 2018 Feb 6;13(1):7. doi: 10.1186/s13024-018-0237-9.

4.

Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42.

Cao Y, Jia X, Wei Y, Liu M, Liu J, Li H.

Evid Based Complement Alternat Med. 2016;2016:6840432. doi: 10.1155/2016/6840432. Epub 2016 Nov 29.

5.

Tau-tubulin kinase.

Ikezu S, Ikezu T.

Front Mol Neurosci. 2014 Apr 28;7:33. doi: 10.3389/fnmol.2014.00033. eCollection 2014. Review.

6.

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.

Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):173-81. doi: 10.1107/S2053230X14000144. Epub 2014 Jan 21.

7.

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T.

Am J Pathol. 2014 Mar;184(3):808-18. doi: 10.1016/j.ajpath.2013.11.026. Epub 2014 Jan 10.

8.

X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors.

Xue Y, Wan PT, Hillertz P, Schweikart F, Zhao Y, Wissler L, Dekker N.

ChemMedChem. 2013 Nov;8(11):1846-54. doi: 10.1002/cmdc.201300274. Epub 2013 Sep 13.

PMID:
24039150
9.

Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.

Lund H, Cowburn RF, Gustafsson E, Strömberg K, Svensson A, Dahllund L, Malinowsky D, Sunnemark D.

Brain Pathol. 2013 Jul;23(4):378-89. doi: 10.1111/bpa.12001. Epub 2012 Nov 20.

PMID:
23088643
10.

Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese.

Yu NN, Yu JT, Xiao JT, Zhang HW, Lu RC, Jiang H, Xing ZH, Tan L.

Neurosci Lett. 2011 Mar 10;491(1):83-6. doi: 10.1016/j.neulet.2011.01.011. Epub 2011 Jan 8.

PMID:
21219968
11.

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.

Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T.

FASEB J. 2010 Aug;24(8):2904-15. doi: 10.1096/fj.09-150144. Epub 2010 Mar 30.

PMID:
20354135
12.

Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort.

Vázquez-Higuera JL, Martínez-García A, Sánchez-Juan P, Rodríguez-Rodríguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O.

Neurobiol Aging. 2011 Mar;32(3):550.e5-9. doi: 10.1016/j.neurobiolaging.2009.12.021. Epub 2010 Jan 22.

PMID:
20096481
13.
14.

The microtubule-associated protein tau is also phosphorylated on tyrosine.

Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P.

J Alzheimers Dis. 2009;18(1):1-9. doi: 10.3233/JAD-2009-1116. Review.

PMID:
19542604
15.

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T.

J Neurosci. 2008 Dec 31;28(53):14511-21. doi: 10.1523/JNEUROSCI.3417-08.2008.

16.

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