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Items: 1 to 20 of 54


The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers.

Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF.

Clin Interv Aging. 2018 Sep 4;13:1565-1577. doi: 10.2147/CIA.S160756. eCollection 2018.


A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.

Justice JN, Ferrucci L, Newman AB, Aroda VR, Bahnson JL, Divers J, Espeland MA, Marcovina S, Pollak MN, Kritchevsky SB, Barzilai N, Kuchel GA.

Geroscience. 2018 Dec;40(5-6):419-436. doi: 10.1007/s11357-018-0042-y. Epub 2018 Aug 27. Review.


Integrative computational evaluation of genetic markers for Alzheimer's disease.

Li Z, Xiong Z, Manor LC, Cao H, Li T.

Saudi J Biol Sci. 2018 Jul;25(5):996-1002. doi: 10.1016/j.sjbs.2018.05.019. Epub 2018 May 18.


Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.

Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ, Wharton SB.

Neuroscience. 2018 Oct 15;390:46-59. doi: 10.1016/j.neuroscience.2018.07.029. Epub 2018 Jul 27.


Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI.

Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8.


40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain.

Gubbi S, Quipildor GF, Barzilai N, Huffman DM, Milman S.

J Mol Endocrinol. 2018 Jul;61(1):T171-T185. doi: 10.1530/JME-18-0093. Epub 2018 May 8. Review.


Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.

Williams DM, Karlsson IK, Pedersen NL, Hägg S.

Neurology. 2018 Jan 23;90(4):e291-e297. doi: 10.1212/WNL.0000000000004854. Epub 2017 Dec 27.


Neurotrophic and Neuroregenerative Effects of GH/IGF1.

Bianchi VE, Locatelli V, Rizzi L.

Int J Mol Sci. 2017 Nov 17;18(11). pii: E2441. doi: 10.3390/ijms18112441. Review.


C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by Aβ25-35 via the PI3K/Akt Pathway.

Zhang J, Shu Y, Qu Y, Zhang L, Chu T, Zheng Y, Zhao H.

J Mol Neurosci. 2017 Dec;63(3-4):412-418. doi: 10.1007/s12031-017-0991-0. Epub 2017 Nov 6.


Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells.

Zimbone S, Monaco I, Gianì F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12684. Epub 2017 Nov 1.


The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice.

Lin KH, Chiu CH, Kuo WW, Ju DT, Shen CY, Chen RJ, Lin CC, Viswanadha VP, Liu JS, Huang RS, Huang CY.

Environ Toxicol. 2018 Jan;33(1):83-92. doi: 10.1002/tox.22498. Epub 2017 Oct 25.


Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia.

Quinlan P, Horvath A, Nordlund A, Wallin A, Svensson J.

Psychoneuroendocrinology. 2017 Dec;86:169-175. doi: 10.1016/j.psyneuen.2017.09.018. Epub 2017 Sep 21.


Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL.

Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9.


Impact of morphine on the expression of insulin receptor and protein levels of insulin/IGFs in rat neural stem cells.

Salarinasab S, Nourazarian A, Nikanfar M, Abdyazdani N, Kazemi M, Feizy N, Rahbarghazi R.

Neurosci Lett. 2017 Nov 1;660:147-154. doi: 10.1016/j.neulet.2017.09.035. Epub 2017 Sep 18.


Insulin-like growth factor type 1 and its relation with neuropsychiatric disorders.

Zegarra-Valdivia JA.

Medwave. 2017 Aug 28;17(7):e7031. doi: 10.5867/medwave.2017.07.7031. Review. Spanish, English.


Sex-Specific Gene Expression and Life Span Regulation.

Tower J.

Trends Endocrinol Metab. 2017 Oct;28(10):735-747. doi: 10.1016/j.tem.2017.07.002. Epub 2017 Aug 2. Review.


Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.

Tarantini S, Tran CHT, Gordon GR, Ungvari Z, Csiszar A.

Exp Gerontol. 2017 Aug;94:52-58. doi: 10.1016/j.exger.2016.11.004. Epub 2016 Nov 12. Review.


Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling.

Kleinridders A.

J Neuroendocrinol. 2016 Nov;28(11). doi: 10.1111/jne.12433.


Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.

Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A.

Age (Dordr). 2016 Aug;38(4):273-289. doi: 10.1007/s11357-016-9931-0. Epub 2016 Sep 9.


Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.

Kamphuis W, Kooijman L, Schetters S, Orre M, Hol EM.

Biochim Biophys Acta. 2016 Oct;1862(10):1847-60. doi: 10.1016/j.bbadis.2016.07.007. Epub 2016 Jul 15.

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