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Items: 1 to 20 of 69


PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.

Knight WE, Chen S, Zhang Y, Oikawa M, Wu M, Zhou Q, Miller CL, Cai Y, Mickelsen DM, Moravec C, Small EM, Abe J, Yan C.

Proc Natl Acad Sci U S A. 2016 Oct 20. pii: 201607728. [Epub ahead of print]


Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

Abe J, Morrell C.

Circ Res. 2016 May 13;118(10):1457-60. doi: 10.1161/CIRCRESAHA.116.308699. No abstract available.


Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events.

Heo KS, Berk BC, Abe J.

Antioxid Redox Signal. 2016 Sep 1;25(7):435-50. doi: 10.1089/ars.2015.6556.


Axl modulates immune activation of smooth muscle cells in vein graft remodeling.

Batchu SN, Xia J, Ko KA, Doyley MM, Abe J, Morrell CN, Korshunov VA.

Am J Physiol Heart Circ Physiol. 2015 Sep 15;309(6):H1048-58. doi: 10.1152/ajpheart.00495.2015.


Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion.

Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe J, Morrell CN.

Circulation. 2015 Jul 7;132(1):47-58. doi: 10.1161/CIRCULATIONAHA.115.015656.


PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C.

PLoS One. 2015 Apr 17;10(4):e0124494. doi: 10.1371/journal.pone.0124494.


Novel mechanisms of endothelial mechanotransduction.

Abe J, Berk BC.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2378-86. doi: 10.1161/ATVBAHA.114.303428. Review.


Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J.

J Immunol. 2014 Oct 1;193(7):3803-15. doi: 10.4049/jimmunol.1400571.


ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.

Heo KS, Cushman HJ, Akaike M, Woo CH, Wang X, Qiu X, Fujiwara K, Abe J.

Circulation. 2014 Jul 8;130(2):180-91. doi: 10.1161/CIRCULATIONAHA.113.005991.


Shear stress and atherosclerosis.

Heo KS, Fujiwara K, Abe J.

Mol Cells. 2014 Jun;37(6):435-40. doi: 10.14348/molcells.2014.0078. Review.


Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.

Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe J, Yan C.

J Mol Cell Cardiol. 2013 Nov;64:11-9. doi: 10.1016/j.yjmcc.2013.08.003.


Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation.

Abe J, Manabe I, Aikawa M, Aikawa E.

Int J Inflam. 2013;2013:953463. doi: 10.1155/2013/953463. No abstract available.


De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.

Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J.

Circ Res. 2013 Mar 15;112(6):911-23. doi: 10.1161/CIRCRESAHA.111.300179.


Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.

Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):321-9. doi: 10.1161/ATVBAHA.112.300619.


p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells.

Kim GY, Nigro P, Fujiwara K, Abe J, Berk BC.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2974-80. doi: 10.1161/ATVBAHA.112.300054.


Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation.

Le NT, Corsetti JP, Dehoff-Sparks JL, Sparks CE, Fujiwara K, Abe J.

Int J Inflam. 2012;2012:678190.


Glucagon-like peptide-1 and its cardiovascular effects.

Heo KS, Fujiwara K, Abe J.

Curr Atheroscler Rep. 2012 Oct;14(5):422-8. doi: 10.1007/s11883-012-0265-9. Review.


p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J.

Circ Res. 2012 Feb 17;110(4):536-50. doi: 10.1161/CIRCRESAHA.111.254730.


PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.

Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J.

J Cell Biol. 2011 May 30;193(5):867-84. doi: 10.1083/jcb.201010051.

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