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Items: 1 to 20 of 58

1.

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 May 30. pii: jbc.M117.788448. doi: 10.1074/jbc.M117.788448. [Epub ahead of print]

2.

The Troubled Touch of Autism.

Tuttle AH, Bartsch VB, Zylka MJ.

Cell. 2016 Jul 14;166(2):273-4. doi: 10.1016/j.cell.2016.06.054.

3.

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ.

PLoS One. 2016 May 27;11(5):e0156439. doi: 10.1371/journal.pone.0156439. eCollection 2016.

4.

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

Pearson BL, Simon JM, McCoy ES, Salazar G, Fragola G, Zylka MJ.

Nat Commun. 2016 Mar 31;7:11173. doi: 10.1038/ncomms11173.

5.

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

Judson MC, Wallace ML, Sidorov MS, Burette AC, Gu B, van Woerden GM, King IF, Han JE, Zylka MJ, Elgersma Y, Weinberg RJ, Philpot BD.

Neuron. 2016 Apr 6;90(1):56-69. doi: 10.1016/j.neuron.2016.02.040. Epub 2016 Mar 24.

6.

Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact.

Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, Evans JA, Brager AJ, Zylka MJ, Paul KN, Philpot BD, DeBruyne JP.

J Neurosci. 2015 Oct 7;35(40):13587-98. doi: 10.1523/JNEUROSCI.2194-15.2015.

7.

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.

Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ.

Cell. 2015 Aug 13;162(4):795-807. doi: 10.1016/j.cell.2015.06.045. Epub 2015 Aug 6.

8.

Sex, drugs and pain control.

Brings VE, Zylka MJ.

Nat Neurosci. 2015 Aug;18(8):1059-60. doi: 10.1038/nn.4057. No abstract available.

9.

Gene length matters in neurons.

Zylka MJ, Simon JM, Philpot BD.

Neuron. 2015 Apr 22;86(2):353-5. doi: 10.1016/j.neuron.2015.03.059.

10.

Lipid kinases as therapeutic targets for chronic pain.

Loo L, Wright BD, Zylka MJ.

Pain. 2015 Apr;156 Suppl 1:S2-10. doi: 10.1097/01.j.pain.0000460345.92588.4b. Review.

11.

Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord.

McCoy E, Street S, Taylor-Blake B, Yi J, Edwards M, Wightman M, Zylka M.

Version 2. F1000Res. 2014 Jul 21 [revised 2014 Sep 19];3:163. doi: 10.12688/f1000research.4563.2. eCollection 2014.

12.

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C.

Wright BD, Simpson C, Stashko M, Kireev D, Hull-Ryde EA, Zylka MJ, Janzen WP.

J Biomol Screen. 2015 Jun;20(5):655-62. doi: 10.1177/1087057114564057. Epub 2014 Dec 22.

13.
14.

Topoisomerase 1 inhibition reversibly impairs synaptic function.

Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111. Epub 2014 Nov 17.

15.

Zylka et al. reply.

Zylka MJ, Philpot BD, King IF.

Nature. 2014 Aug 7;512(7512):E2. doi: 10.1038/nature13584. No abstract available.

16.

Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.

Huang HS, Yoon BJ, Brooks S, Bakal R, Berrios J, Larsen RS, Wallace ML, Han JE, Chung EH, Zylka MJ, Philpot BD.

PLoS One. 2014 May 23;9(5):e98383. doi: 10.1371/journal.pone.0098383. eCollection 2014.

17.

The lipid kinase PIP5K1C regulates pain signaling and sensitization.

Wright BD, Loo L, Street SE, Ma A, Taylor-Blake B, Stashko MA, Jin J, Janzen WP, Frye SV, Zylka MJ.

Neuron. 2014 May 21;82(4):836-47. doi: 10.1016/j.neuron.2014.04.006.

18.

Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling.

Rittiner JE, Brings VE, Zylka MJ.

Mol Pharmacol. 2014 May;85(5):800-10. doi: 10.1124/mol.113.091280. Epub 2014 Mar 7.

19.

Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons.

Coutinho-Budd JC, Snider SB, Fitzpatrick BJ, Rittiner JE, Zylka MJ.

J Negat Results Biomed. 2013 Sep 8;12:13. doi: 10.1186/1477-5751-12-13.

20.

Topoisomerases facilitate transcription of long genes linked to autism.

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ.

Nature. 2013 Sep 5;501(7465):58-62. doi: 10.1038/nature12504. Epub 2013 Aug 28.

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