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Items: 1 to 20 of 27

1.

Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery.

Zhou L, Wang HY, Tong S, Okamoto CT, Shen WC, Zaro JL.

Biomaterials. 2017 Feb;117:24-31. doi: 10.1016/j.biomaterials.2016.11.051. Epub 2016 Nov 27.

PMID:
27923197
2.

Tissue barriers and novel approaches to achieve hepatoselectivity of subcutaneously-injected insulin therapeutics.

Shao J, Zaro JL, Shen WC.

Tissue Barriers. 2016 Mar 4;4(2):e1156804. doi: 10.1080/21688370.2016.1156804. eCollection 2016 Apr-Jun. Review.

3.

Proinsulin-Transferrin Fusion Protein Exhibits a Prolonged and Selective Effect on the Control of Hepatic Glucose Production in an Experimental Model of Type 1 Diabetes.

Shao J, Zaro JL, Shen WC.

Mol Pharm. 2016 Aug 1;13(8):2641-6. doi: 10.1021/acs.molpharmaceut.6b00168. Epub 2016 Jul 11.

PMID:
27280852
4.

Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells.

Yeh TH, Chen YR, Chen SY, Shen WC, Ann DK, Zaro JL, Shen LJ.

Mol Pharm. 2016 Jan 4;13(1):262-71. doi: 10.1021/acs.molpharmaceut.5b00706. Epub 2015 Dec 17.

PMID:
26642391
5.

Lipid-based drug carriers for prodrugs to enhance drug delivery.

Zaro JL.

AAPS J. 2015 Jan;17(1):83-92. doi: 10.1208/s12248-014-9670-z. Epub 2014 Oct 1. Review.

6.

Interaction between cell-penetrating peptides and acid-sensitive anionic oligopeptides as a model for the design of targeted drug carriers.

Sun C, Shen WC, Tu J, Zaro JL.

Mol Pharm. 2014 May 5;11(5):1583-90. doi: 10.1021/mp400747k. Epub 2014 Apr 15.

7.

Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide.

Fei L, Yap LP, Conti PS, Shen WC, Zaro JL.

Biomaterials. 2014 Apr;35(13):4082-7. doi: 10.1016/j.biomaterials.2014.01.047. Epub 2014 Feb 6.

8.

Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production.

Wang Y, Shao J, Zaro JL, Shen WC.

Diabetes. 2014 May;63(5):1779-88. doi: 10.2337/db13-0973. Epub 2013 Dec 18.

9.

Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.).

Zhang D, Lee HF, Pettit SC, Zaro JL, Huang N, Shen WC.

BMC Biotechnol. 2012 Nov 30;12:92. doi: 10.1186/1472-6750-12-92.

10.

Fusion protein linkers: property, design and functionality.

Chen X, Zaro JL, Shen WC.

Adv Drug Deliv Rev. 2013 Oct;65(10):1357-69. doi: 10.1016/j.addr.2012.09.039. Epub 2012 Sep 29. Review.

11.

Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide.

Kenien R, Shen WC, Zaro JL.

J Drug Target. 2012 Nov;20(9):793-800. doi: 10.3109/1061186X.2012.719899. Epub 2012 Sep 20.

PMID:
22994388
12.

Fatty acids as therapeutic auxiliaries for oral and parenteral formulations.

Hackett MJ, Zaro JL, Shen WC, Guley PC, Cho MJ.

Adv Drug Deliv Rev. 2013 Oct;65(10):1331-9. doi: 10.1016/j.addr.2012.07.012. Epub 2012 Aug 17. Review.

13.

Pharmacokinetics of recombinant bifunctional fusion proteins.

Chen X, Zaro JL, Shen WC.

Expert Opin Drug Metab Toxicol. 2012 May;8(5):581-95. doi: 10.1517/17425255.2012.673585. Epub 2012 Mar 20. Review.

14.

Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery.

Zaro JL, Fei L, Shen WC.

J Control Release. 2012 Mar 28;158(3):357-61. doi: 10.1016/j.jconrel.2012.01.039. Epub 2012 Feb 1.

PMID:
22326404
15.

MAP-mediated nuclear delivery of a cargo protein.

Kenien R, Zaro JL, Shen WC.

J Drug Target. 2012 May;20(4):329-37. doi: 10.3109/1061186X.2011.649481. Epub 2012 Jan 9.

PMID:
22225540
16.

Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy.

Mo RH, Zaro JL, Shen WC.

Mol Pharm. 2012 Feb 6;9(2):299-309. doi: 10.1021/mp200481g. Epub 2011 Dec 28.

17.

Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.

Wang Y, Chen YS, Zaro JL, Shen WC.

J Control Release. 2011 Nov 7;155(3):386-92. doi: 10.1016/j.jconrel.2011.06.029. Epub 2011 Jul 2.

18.

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells.

Mo RH, Zaro JL, Ou JH, Shen WC.

Mol Biotechnol. 2012 May;51(1):1-8. doi: 10.1007/s12033-011-9422-6.

19.

Effects of receptor binding on plasma half-life of bifunctional transferrin fusion proteins.

Chen X, Lee HF, Zaro JL, Shen WC.

Mol Pharm. 2011 Apr 4;8(2):457-65. doi: 10.1021/mp1003064. Epub 2011 Feb 22.

20.

The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides.

Fei L, Ren L, Zaro JL, Shen WC.

J Drug Target. 2011 Sep;19(8):675-80. doi: 10.3109/1061186X.2010.531729. Epub 2010 Dec 9.

PMID:
21142649

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