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The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.

Wekselman I, Zimmerman E, Davidovich C, Belousoff M, Matzov D, Krupkin M, Rozenberg H, Bashan A, Friedlander G, Kjeldgaard J, Ingmer H, Lindahl L, Zengel JM, Yonath A.

Structure. 2017 Jun 21. pii: S0969-2126(17)30184-3. doi: 10.1016/j.str.2017.06.004. [Epub ahead of print]


A Bright Future for Antibiotics?

Matzov D, Bashan A, Yonath A.

Annu Rev Biochem. 2017 Jun 20;86:567-583. doi: 10.1146/annurev-biochem-061516-044617. Review.


Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.

Belousoff MJ, Eyal Z, Radjainia M, Ahmed T, Bamert RS, Matzov D, Bashan A, Zimmerman E, Mishra S, Cameron D, Elmlund H, Peleg AY, Bhushan S, Lithgow T, Yonath A.

MBio. 2017 May 9;8(3). pii: e00395-17. doi: 10.1128/mBio.00395-17.


A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.

Eyal Z, Matzov D, Krupkin M, Paukner S, Riedl R, Rozenberg H, Zimmerman E, Bashan A, Yonath A.

Sci Rep. 2016 Dec 13;6:39004. doi: 10.1038/srep39004.


The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering.

Zaccai G, Natali F, Peters J, Řihová M, Zimmerman E, Ollivier J, Combet J, Maurel MC, Bashan A, Yonath A.

Sci Rep. 2016 Nov 16;6:37138. doi: 10.1038/srep37138.


Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.

Krupkin M, Wekselman I, Matzov D, Eyal Z, Diskin Posner Y, Rozenberg H, Zimmerman E, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6796-E6805. Epub 2016 Oct 19.


2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.

Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G.

Cell Rep. 2016 Jul 12;16(2):288-94. doi: 10.1016/j.celrep.2016.06.014. Epub 2016 Jun 30.


Ribosomal Antibiotics: Contemporary Challenges.

Auerbach-Nevo T, Baram D, Bashan A, Belousoff M, Breiner E, Davidovich C, Cimicata G, Eyal Z, Halfon Y, Krupkin M, Matzov D, Metz M, Rufayda M, Peretz M, Pick O, Pyetan E, Rozenberg H, Shalev-Benami M, Wekselman I, Zarivach R, Zimmerman E, Assis N, Bloch J, Israeli H, Kalaora R, Lim L, Sade-Falk O, Shapira T, Taha-Salaime L, Tang H, Yonath A.

Antibiotics (Basel). 2016 Jun 29;5(3). pii: E24. doi: 10.3390/antibiotics5030024. Review.


Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

Eyal Z, Matzov D, Krupkin M, Wekselman I, Paukner S, Zimmerman E, Rozenberg H, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5805-14. doi: 10.1073/pnas.1517952112. Epub 2015 Oct 13.


A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.

Sun L, Xiong Y, Bashan A, Zimmerman E, Shulman Daube S, Peleg Y, Albeck S, Unger T, Yonath H, Krupkin M, Matzov D, Yonath A.

Chembiochem. 2015 Jul 6;16(10):1415-9. doi: 10.1002/cbic.201500205. Epub 2015 May 26.


A new system for naming ribosomal proteins.

Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M.

Curr Opin Struct Biol. 2014 Feb;24:165-9. doi: 10.1016/ Epub 2014 Feb 10. Review.


Protoribosome by quantum kernel energy method.

Huang L, Krupkin M, Bashan A, Yonath A, Massa L.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14900-5. doi: 10.1073/pnas.1314112110. Epub 2013 Aug 26.


[The three-dimensional structure of the ribosome].

Yonath A.

Harefuah. 2012 May;151(5):256. Hebrew. No abstract available.


An exit cavity was crucial to the polymerase activity of the early ribosome.

Fox GE, Tran Q, Yonath A.

Astrobiology. 2012 Jan;12(1):57-60. doi: 10.1089/ast.2011.0692. Epub 2011 Dec 22.


Tough science.

Yonath AE.

Nature. 2011 Oct 12;478(7368):S6-7. doi: 10.1038/478S6a. No abstract available.


A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome.

Krupkin M, Matzov D, Tang H, Metz M, Kalaora R, Belousoff MJ, Zimmerman E, Bashan A, Yonath A.

Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2972-8. doi: 10.1098/rstb.2011.0146.


X-ray crystallography at the heart of life science.

Yonath A.

Curr Opin Struct Biol. 2011 Oct;21(5):622-6. doi: 10.1016/ Epub 2011 Aug 6.


Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.

Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. doi: 10.1073/pnas.1019406108. Epub 2011 Jan 31.


The Proto-Ribosome: an ancient nano-machine for peptide bond formation.

Davidovich C, Belousoff M, Wekselman I, Shapira T, Krupkin M, Zimmerman E, Bashan A, Yonath A.

Isr J Chem. 2010 Jun 18;50(1):29-35.


Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture).

Yonath A.

Angew Chem Int Ed Engl. 2010 Jun 14;49(26):4341-54. doi: 10.1002/anie.201001297.


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