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Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release.

Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Li K, Niu H, Lee KH, Huang W.

Free Radic Biol Med. 2017 Jul;108:247-257. doi: 10.1016/j.freeradbiomed.2017.02.018. Epub 2017 Feb 8.


Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.

Chen IC, Tan MS, Wu BN, Chai CY, Yeh JL, Chou SH, Chen IJ, Dai ZK.

Pediatr Pulmonol. 2017 Apr;52(4):443-457. doi: 10.1002/ppul.23610. Epub 2016 Dec 28.


Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release.

Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Lu Y, Li K, Niu H, Lee KH, Huang W.

Sci Rep. 2016 Nov 2;6:36222. doi: 10.1038/srep36222.


Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway.

Wu JR, Yeh JL, Liou SF, Dai ZK, Wu BN, Hsu JH.

Int J Biol Sci. 2016 Jul 18;12(9):1063-73. doi: 10.7150/ijbs.16430. eCollection 2016.


Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss.

Cheng TL, Lai CH, Shieh SJ, Jou YB, Yeh JL, Yang AL, Wang YH, Wang CZ, Chen CH, Shi GY, Ho ML, Wu HL.

Sci Rep. 2016 Jun 17;6:28340. doi: 10.1038/srep28340.


Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells.

Wu JR, Hsu JH, Dai ZK, Wu BN, Chen IJ, Liou SF, Yeh JL.

J Pharm Pharmacol. 2016 Jun;68(6):810-8. doi: 10.1111/jphp.12555. Epub 2016 Apr 25.


Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization.

Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ.

Kaohsiung J Med Sci. 2016 Feb;32(2):55-67. doi: 10.1016/j.kjms.2016.01.005. Epub 2016 Feb 24.


Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord.

Huang SH, Wu SH, Lee SS, Chang KP, Chai CY, Yeh JL, Lin SD, Kwan AL, David Wang HM, Lai CS.

PLoS One. 2015 Sep 14;10(9):e0137563. doi: 10.1371/journal.pone.0137563. eCollection 2015.


Association of diabetes and cancer mortality in American Indians: the Strong Heart Study.

Best LG, García-Esquinas E, Yeh JL, Yeh F, Zhang Y, Lee ET, Howard BV, Farley JH, Welty TK, Rhoades DA, Rhoades ER, Umans JG, Navas-Acien A.

Cancer Causes Control. 2015 Nov;26(11):1551-60. doi: 10.1007/s10552-015-0648-7. Epub 2015 Aug 7.


Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury.

Wu SH, Huang SH, Lo YC, Chai CY, Lee SS, Chang KP, Lin SD, Lai CS, Yeh JL, Kwan AL.

Cytotherapy. 2015 Aug;17(8):1066-75. doi: 10.1016/j.jcyt.2015.03.687.


The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K⁺-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries.

Dai ZK, Liu YW, Hsu JH, Yeh JL, Chen IJ, Wu JR, Wu BN.

Int J Biol Sci. 2015 Apr 25;11(6):633-42. doi: 10.7150/ijbs.11127. eCollection 2015.


Third-degree hindpaw burn injury induced apoptosis of lumbar spinal cord ventral horn motor neurons and sciatic nerve and muscle atrophy in rats.

Wu SH, Huang SH, Cheng KI, Chai CY, Yeh JL, Wu TC, Hsu YC, Kwan AL.

Biomed Res Int. 2015;2015:372819. doi: 10.1155/2015/372819. Epub 2015 Jan 28.


KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.

Liou SF, Hsu JH, Chu HC, Lin HH, Chen IJ, Yeh JL.

J Cell Physiol. 2015 Sep;230(9):2038-48. doi: 10.1002/jcp.24904.


Regional cost variation for acute pancreatitis in the U.S.

Yeh JL, Wu S, Wu BU.

JOP. 2014 Sep 28;15(5):448-54. doi: 10.6092/1590-8577/2797.


Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.

Hsu JH, Yang RC, Lin SJ, Liou SF, Dai ZK, Yeh JL, Wu JR.

Shock. 2014 Dec;42(6):540-7. doi: 10.1097/SHK.0000000000000254.


Baicalein inhibits HMGB1 release and MMP-2/-9 expression in lipopolysaccharide-induced cardiac hypertrophy.

Chen HM, Liou SF, Hsu JH, Chen TJ, Cheng TL, Chiu CC, Yeh JL.

Am J Chin Med. 2014;42(4):785-97. doi: 10.1142/S0192415X14500505.


Autologous fat grafting alleviates burn-induced neuropathic pain in rats.

Huang SH, Wu SH, Chang KP, Cheng KI, Lee SS, Kwan AL, Yeh JL, Tsai HP, Lin SD, Lai CS.

Plast Reconstr Surg. 2014 Jun;133(6):1396-405. doi: 10.1097/PRS.0000000000000169.


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