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Items: 1 to 20 of 22


Immune checkpoint blockade in infectious diseases.

Wykes MN, Lewin SR.

Nat Rev Immunol. 2018 Feb;18(2):91-104. doi: 10.1038/nri.2017.112. Epub 2017 Oct 9. Review.


Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, RĂ©nia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN.

Immunity. 2016 Aug 16;45(2):333-45. doi: 10.1016/j.immuni.2016.07.017.


Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria.

Horne-Debets JM, Karunarathne DS, Faleiro RJ, Poh CM, Renia L, Wykes MN.

Sci Rep. 2016 May 24;6:26210. doi: 10.1038/srep26210.


Malaria drives T cells to exhaustion.

Wykes MN, Horne-Debets JM, Leow CY, Karunarathne DS.

Front Microbiol. 2014 May 27;5:249. doi: 10.3389/fmicb.2014.00249. eCollection 2014. Review.


PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.

Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN.

Cell Rep. 2013 Dec 12;5(5):1204-13. doi: 10.1016/j.celrep.2013.11.002. Epub 2013 Dec 5.


Why haven't we made an efficacious vaccine for malaria?

Wykes MN.

EMBO Rep. 2013 Aug;14(8):661. doi: 10.1038/embor.2013.103. Epub 2013 Jul 12. No abstract available.


Long-term antibody memory induced by synthetic peptide vaccination is protective against Streptococcus pyogenes infection and is independent of memory T cell help.

Pandey M, Wykes MN, Hartas J, Good MF, Batzloff MR.

J Immunol. 2013 Mar 15;190(6):2692-701. doi: 10.4049/jimmunol.1202333. Epub 2013 Feb 11.


Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.

Liu XQ, Stacey KJ, Horne-Debets JM, Cridland JA, Fischer K, Narum D, Mackay F, Pierce SK, Wykes MN.

Eur J Immunol. 2012 Dec;42(12):3291-301. doi: 10.1002/eji.201242689. Epub 2012 Oct 16.


The mammalian PYHIN gene family: phylogeny, evolution and expression.

Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ.

BMC Evol Biol. 2012 Aug 7;12:140.


Dendritic cells: the Trojan horse of malaria?

Wykes MN, Horne-Debets J.

Int J Parasitol. 2012 May 15;42(6):583-7. doi: 10.1016/j.ijpara.2012.03.002. Epub 2012 Mar 21.


Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity?

Wykes MN.

Trends Parasitol. 2012 May;28(5):182-6. doi: 10.1016/ Epub 2012 Feb 25.


Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice.

Wykes MN, Kay JG, Manderson A, Liu XQ, Brown DL, Richard DJ, Wipasa J, Jiang SH, Jones MK, Janse CJ, Waters AP, Pierce SK, Miller LH, Stow JL, Good MF.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11205-10. doi: 10.1073/pnas.1108579108. Epub 2011 Jun 20.


A novel synthetic adjuvant enhances dendritic cell function.

Phillipps KS, Wykes MN, Liu XQ, Brown M, Blanchfield J, Toth I.

Immunology. 2009 Sep;128(1 Suppl):e582-8. doi: 10.1111/j.1365-2567.2008.03038.x. Epub 2008 Dec 26.


What have we learnt from mouse models for the study of malaria?

Wykes MN, Good MF.

Eur J Immunol. 2009 Aug;39(8):2004-7. doi: 10.1002/eji.200939552.


Soluble CD38 significantly prolongs the lifespan of memory B-cell responses.

Liu XQ, Hart DN, MacPherson GG, Good MF, Wykes MN.

Immunology. 2008 Sep;125(1):14-20. doi: 10.1111/j.1365-2567.2008.02914.x.


What really happens to dendritic cells during malaria?

Wykes MN, Good MF.

Nat Rev Microbiol. 2008 Nov;6(11):864-70. doi: 10.1038/nrmicro1988. Epub 2008 Aug 19. Review.


Systemic tumor necrosis factor generated during lethal Plasmodium infections impairs dendritic cell function.

Wykes MN, Liu XQ, Jiang S, Hirunpetcharat C, Good MF.

J Immunol. 2007 Sep 15;179(6):3982-7.


Plasmodium strain determines dendritic cell function essential for survival from malaria.

Wykes MN, Liu XQ, Beattie L, Stanisic DI, Stacey KJ, Smyth MJ, Thomas R, Good MF.

PLoS Pathog. 2007 Jul;3(7):e96.


Plasmodium yoelii can ablate vaccine-induced long-term protection in mice.

Wykes MN, Zhou YH, Liu XQ, Good MF.

J Immunol. 2005 Aug 15;175(4):2510-6.


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