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Items: 1 to 20 of 28


Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells.

Klawitter M, Hakozaki M, Kobayashi H, Krupkova O, Quero L, Ospelt C, Gay S, Hausmann O, Liebscher T, Meier U, Sekiguchi M, Konno S, Boos N, Ferguson SJ, Wuertz K.

Eur Spine J. 2014 Sep;23(9):1878-91. doi: 10.1007/s00586-014-3442-4. Epub 2014 Jul 5.


Regenerative therapies for equine degenerative joint disease: a preliminary study.

Broeckx S, Zimmerman M, Crocetti S, Suls M, Mariën T, Ferguson SJ, Chiers K, Duchateau L, Franco-Obregón A, Wuertz K, Spaas JH.

PLoS One. 2014 Jan 20;9(1):e85917. doi: 10.1371/journal.pone.0085917. eCollection 2014.


Inflammatory mediators in intervertebral disk degeneration and discogenic pain.

Wuertz K, Haglund L.

Global Spine J. 2013 Jun;3(3):175-84. doi: 10.1055/s-0033-1347299. Epub 2013 May 21. Review.


Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.

Quero L, Klawitter M, Schmaus A, Rothley M, Sleeman J, Tiaden AN, Klasen J, Boos N, Hottiger MO, Wuertz K, Richards PJ.

Arthritis Res Ther. 2013 Aug 22;15(4):R94. doi: 10.1186/ar4274.


Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.

Klawitter M, Quero L, Klasen J, Gloess AN, Klopprogge B, Hausmann O, Boos N, Wuertz K.

J Inflamm (Lond). 2012 Aug 21;9(1):29. doi: 10.1186/1476-9255-9-29.


Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.

Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, Richards PJ.

J Biol Chem. 2012 Jun 15;287(25):21335-45. doi: 10.1074/jbc.M112.341032. Epub 2012 May 3.


Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases.

Wuertz K, Vo N, Kletsas D, Boos N.

Eur Cell Mater. 2012 Feb 16;23:103-19; discussion 119-20.


Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index.

Weiler C, Lopez-Ramos M, Mayer HM, Korge A, Siepe CJ, Wuertz K, Weiler V, Boos N, Nerlich AG.

BMC Res Notes. 2011 Nov 16;4:497. doi: 10.1186/1756-0500-4-497.


Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation.

Weiler C, Schietzsch M, Kirchner T, Nerlich AG, Boos N, Wuertz K.

Eur Spine J. 2012 Aug;21 Suppl 6:S810-8. doi: 10.1007/s00586-011-1922-3. Epub 2011 Aug 12.


Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration.

Klawitter M, Quero L, Bertolo A, Mehr M, Stoyanov J, Nerlich AG, Klasen J, Aebli N, Boos N, Wuertz K.

J Negat Results Biomed. 2011 Jul 29;10:9. doi: 10.1186/1477-5751-10-9.


Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells.

Klawitter M, Quero L, Klasen J, Liebscher T, Nerlich A, Boos N, Wuertz K.

Eur Spine J. 2012 Aug;21 Suppl 6:S850-9. doi: 10.1007/s00586-011-1919-y. Epub 2011 Jul 26.


Development of a novel automated cell isolation, expansion, and characterization platform.

Franscini N, Wuertz K, Patocchi-Tenzer I, Durner R, Boos N, Graf-Hausner U.

J Lab Autom. 2011 Jun;16(3):204-13. doi: 10.1016/j.jala.2011.01.002. Epub 2011 May 16.


The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo.

Wuertz K, Quero L, Sekiguchi M, Klawitter M, Nerlich A, Konno S, Kikuchi S, Boos N.

Spine (Phila Pa 1976). 2011 Oct 1;36(21):E1373-84. doi: 10.1097/BRS.0b013e318221e655.


Biological response of the intervertebral disc to repetitive short-term cyclic torsion.

Chan SC, Ferguson SJ, Wuertz K, Gantenbein-Ritter B.

Spine (Phila Pa 1976). 2011 Nov 15;36(24):2021-30. doi: 10.1097/BRS.0b013e318203aea5.


Bupivacaine--the deadly friend of intervertebral disc cells?

Quero L, Klawitter M, Nerlich AG, Leonardi M, Boos N, Wuertz K.

Spine J. 2011 Jan;11(1):46-53. doi: 10.1016/j.spinee.2010.11.001.


Region-dependent aggrecan degradation patterns in the rat intervertebral disc are affected by mechanical loading in vivo.

latridis JC, Godburn K, Wuertz K, Alini M, Roughley PJ.

Spine (Phila Pa 1976). 2011 Feb 1;36(3):203-9. doi: 10.1097/BRS.0b013e3181cec247.


Age-related variation in cell density of human lumbar intervertebral disc.

Liebscher T, Haefeli M, Wuertz K, Nerlich AG, Boos N.

Spine (Phila Pa 1976). 2011 Jan 15;36(2):153-9. doi: 10.1097/BRS.0b013e3181cd588c.


Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc.

Weiler C, Nerlich AG, Schaaf R, Bachmeier BE, Wuertz K, Boos N.

Eur Spine J. 2010 Oct;19(10):1761-70. doi: 10.1007/s00586-010-1392-z. Epub 2010 Apr 7.


Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration.

Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K, Boos N.

Eur Spine J. 2009 Nov;18(11):1573-86. doi: 10.1007/s00586-009-1031-8. Epub 2009 May 23.


Peroxynitrite induces gene expression in intervertebral disc cells.

Poveda L, Hottiger M, Boos N, Wuertz K.

Spine (Phila Pa 1976). 2009 May 15;34(11):1127-33. doi: 10.1097/BRS.0b013e31819f2330.


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