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Items: 1 to 20 of 41

1.

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Wubbolts R, Houweling M, Yan C, Du H, VanderVen BC, Vaandrager AB, Helms JB.

J Biol Chem. 2017 Jul 28;292(30):12436-12448. doi: 10.1074/jbc.M117.778472. Epub 2017 Jun 14.

PMID:
28615446
2.

Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress.

Aardema H, van Tol HTA, Wubbolts RW, Brouwers JFHM, Gadella BM, Roelen BAJ.

Biol Reprod. 2017 May 8. doi: 10.1095/biolreprod.116.146159. [Epub ahead of print]

PMID:
28486699
3.

Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency.

Brinkhof B, van Tol HT, Groot Koerkamp MJ, Wubbolts RW, Haagsman HP, Roelen BA.

PLoS One. 2017 Feb 27;12(2):e0172920. doi: 10.1371/journal.pone.0172920. eCollection 2017.

4.

Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation.

Ferraz MAMM, Henning HHW, Costa PF, Malda J, Melchels FP, Wubbolts R, Stout TAE, Vos PLAM, Gadella BM.

Lab Chip. 2017 Feb 28;17(5):905-916. doi: 10.1039/c6lc01566b.

PMID:
28194463
5.

Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63.

de Goeij BE, Vink T, Ten Napel H, Breij EC, Satijn D, Wubbolts R, Miao D, Parren PW.

Mol Cancer Ther. 2016 Nov;15(11):2688-2697. Epub 2016 Aug 24.

PMID:
27559142
6.

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RR, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.

Stem Cell Reports. 2015 Nov 10;5(5):895-907. doi: 10.1016/j.stemcr.2015.09.002. Epub 2015 Oct 8.

7.

High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates.

de Goeij BE, Satijn D, Freitag CM, Wubbolts R, Bleeker WK, Khasanov A, Zhu T, Chen G, Miao D, van Berkel PH, Parren PW.

Mol Cancer Ther. 2015 May;14(5):1130-40. doi: 10.1158/1535-7163.MCT-14-0798. Epub 2015 Feb 27.

8.

Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus.

Albulescu L, Wubbolts R, van Kuppeveld FJ, Strating JR.

Cell Microbiol. 2015 Aug;17(8):1144-56. doi: 10.1111/cmi.12425. Epub 2015 Mar 10.

PMID:
25645595
9.

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ.

Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29.

10.

Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.

Tuohetahuntila M, Spee B, Kruitwagen HS, Wubbolts R, Brouwers JF, van de Lest CH, Molenaar MR, Houweling M, Helms JB, Vaandrager AB.

Biochim Biophys Acta. 2015 Feb;1851(2):220-30. doi: 10.1016/j.bbalip.2014.12.003. Epub 2014 Dec 9.

PMID:
25500141
11.

FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells.

Boross P, van Montfoort N, Stapels DA, van der Poel CE, Bertens C, Meeldijk J, Jansen JH, Verbeek JS, Ossendorp F, Wubbolts R, Leusen JH.

J Immunol. 2014 Dec 1;193(11):5506-14. doi: 10.4049/jimmunol.1302012. Epub 2014 Oct 29.

12.

The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity.

Lolicato F, Brouwers JF, de Lest CH, Wubbolts R, Aardema H, Priore P, Roelen BA, Helms JB, Gadella BM.

Biol Reprod. 2015 Jan;92(1):16. doi: 10.1095/biolreprod.114.120634. Epub 2014 Oct 8.

PMID:
25297544
13.

Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture.

Wicht O, Li W, Willems L, Meuleman TJ, Wubbolts RW, van Kuppeveld FJ, Rottier PJ, Bosch BJ.

J Virol. 2014 Jul;88(14):7952-61. doi: 10.1128/JVI.00297-14. Epub 2014 May 7.

14.

The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.

Bach FC, Rutten K, Hendriks K, Riemers FM, Cornelissen P, de Bruin A, Arkesteijn GJ, Wubbolts R, Horton WA, Penning LC, Tryfonidou MA.

J Cell Physiol. 2014 Dec;229(12):1999-2014. doi: 10.1002/jcp.24658.

15.

Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging.

Ordonez SR, Amarullah IH, Wubbolts RW, Veldhuizen EJ, Haagsman HP.

Antimicrob Agents Chemother. 2014;58(4):2240-8. doi: 10.1128/AAC.01670-13. Epub 2014 Feb 3.

16.

MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.

ten Broeke T, Wubbolts R, Stoorvogel W.

Cold Spring Harb Perspect Biol. 2013 Dec 1;5(12):a016873. doi: 10.1101/cshperspect.a016873. Review.

17.

Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells.

Kondylis V, van Nispen Tot Pannerden HE, van Dijk S, Ten Broeke T, Wubbolts R, Geerts WJ, Seinen C, Mutis T, Heijnen HF.

Autophagy. 2013 Jun 1;9(6):861-80. doi: 10.4161/auto.24111. Epub 2013 Mar 12.

18.

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.

Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GC, Houweling M, Groot Koerkamp MJ, van Leenen D, Holstege FC, Hazewinkel HA, Creemers LB, Penning LC, Tryfonidou MA.

Arthritis Res Ther. 2013 Jan 29;15(1):R23. doi: 10.1186/ar4157.

19.

Spermatozoa recruit prostasomes in response to capacitation induction.

Aalberts M, Sostaric E, Wubbolts R, Wauben MW, Nolte-'t Hoen EN, Gadella BM, Stout TA, Stoorvogel W.

Biochim Biophys Acta. 2013 Nov;1834(11):2326-35. doi: 10.1016/j.bbapap.2012.08.008. Epub 2012 Aug 24.

PMID:
22940639
20.

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos.

Kuijk EW, van Tol LT, Van de Velde H, Wubbolts R, Welling M, Geijsen N, Roelen BA.

Development. 2012 Mar;139(5):871-82. doi: 10.1242/dev.071688. Epub 2012 Jan 25.

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