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Items: 1 to 20 of 173


Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model.

Collie D, Murchison JT, Wright SH, McLean A, Howard L, Del-Pozo J, Smith S, McLachlan G, Lawrence J, Kay E, Schwarz T, Parys M.

Sci Rep. 2018 Sep 6;8(1):13316. doi: 10.1038/s41598-018-31559-3.


Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates.

Sandoval PJ, Zorn KM, Clark AM, Ekins S, Wright SH.

Mol Pharmacol. 2018 Sep;94(3):1057-1068. doi: 10.1124/mol.117.111443. Epub 2018 Jun 8.


Correlation between Apparent Substrate Affinity and OCT2 Transport Turnover.

Severance AC, Sandoval PJ, Wright SH.

J Pharmacol Exp Ther. 2017 Sep;362(3):405-412. doi: 10.1124/jpet.117.242552. Epub 2017 Jun 14.


Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1.

Martínez-Guerrero LJ, Morales M, Ekins S, Wright SH.

Mol Pharmacol. 2016 Sep;90(3):254-64. doi: 10.1124/mol.116.105056. Epub 2016 Jul 14.


The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules.

Martínez-Guerrero LJ, Evans KK, Dantzler WH, Wright SH.

Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F57-67. doi: 10.1152/ajprenal.00318.2015. Epub 2015 Nov 4.


Making Transporter Models for Drug-Drug Interaction Prediction Mobile.

Ekins S, Clark AM, Wright SH.

Drug Metab Dispos. 2015 Oct;43(10):1642-5. doi: 10.1124/dmd.115.064956. Epub 2015 Jul 21.


Unstirred Water Layers and the Kinetics of Organic Cation Transport.

Shibayama T, Morales M, Zhang X, Martínez-Guerrero LJ, Berteloot A, Secomb TW, Wright SH.

Pharm Res. 2015 Sep;32(9):2937-49. doi: 10.1007/s11095-015-1675-5. Epub 2015 Mar 20.


Xenobiotic transporter expression along the male genital tract.

Klein DM, Wright SH, Cherrington NJ.

Reprod Toxicol. 2014 Aug;47:1-8. doi: 10.1016/j.reprotox.2014.04.009. Epub 2014 May 9.


SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties.

Pelis RM, Wright SH.

Curr Top Membr. 2014;73:233-61. doi: 10.1016/B978-0-12-800223-0.00006-2. Review.


Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis.

Klein DM, Wright SH, Cherrington NJ.

Drug Metab Dispos. 2014 Jan;42(1):89-93. doi: 10.1124/dmd.113.054577. Epub 2013 Oct 15.


Substrate-dependent inhibition of human MATE1 by cationic ionic liquids.

Martínez-Guerrero LJ, Wright SH.

J Pharmacol Exp Ther. 2013 Sep;346(3):495-503. doi: 10.1124/jpet.113.204206. Epub 2013 Jun 19.


Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.

Belzer M, Morales M, Jagadish B, Mash EA, Wright SH.

J Pharmacol Exp Ther. 2013 Aug;346(2):300-10. doi: 10.1124/jpet.113.203257. Epub 2013 May 24.


Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.

Klein DM, Evans KK, Hardwick RN, Dantzler WH, Wright SH, Cherrington NJ.

J Pharmacol Exp Ther. 2013 Jul;346(1):121-9. doi: 10.1124/jpet.113.203265. Epub 2013 May 2.


Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.

Harper JN, Wright SH.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F56-67. doi: 10.1152/ajprenal.00486.2012. Epub 2012 Oct 3.


Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition.

Ekins S, Polli JE, Swaan PW, Wright SH.

Clin Pharmacol Ther. 2012 Nov;92(5):661-5. doi: 10.1038/clpt.2012.164. Epub 2012 Sep 26. No abstract available.


The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection.

Forman RA, deSchoolmeester ML, Hurst RJ, Wright SH, Pemberton AD, Else KJ.

PLoS One. 2012;7(9):e42248. doi: 10.1371/journal.pone.0042248. Epub 2012 Sep 6.


Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.

Zhang X, He X, Baker J, Tama F, Chang G, Wright SH.

J Biol Chem. 2012 Aug 10;287(33):27971-82. doi: 10.1074/jbc.M112.386979. Epub 2012 Jun 21.


Functional significance of conserved cysteines in the human organic cation transporter 2.

Pelis RM, Dangprapai Y, Cheng Y, Zhang X, Terpstra J, Wright SH.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F313-20. doi: 10.1152/ajprenal.00038.2012. Epub 2012 May 9.


Simulations of substrate transport in the multidrug transporter EmrD.

Baker J, Wright SH, Tama F.

Proteins. 2012 Jun;80(6):1620-32. doi: 10.1002/prot.24056. Epub 2012 Mar 20.


Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

Astorga B, Ekins S, Morales M, Wright SH.

J Pharmacol Exp Ther. 2012 Jun;341(3):743-55. doi: 10.1124/jpet.112.191577. Epub 2012 Mar 14.

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