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Items: 1 to 20 of 347

1.

Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.

Ma Z, Ketelhuth DFJ, Wirström T, Ohki T, Forteza MJ, Wang H, Grill V, Wollheim CB, Björklund A.

J Mol Endocrinol. 2019 May 1;62(4):159-168. doi: 10.1530/JME-18-0146.

PMID:
30917339
2.

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells.

Zhang E, Mohammed Al-Amily I, Mohammed S, Luan C, Asplund O, Ahmed M, Ye Y, Ben-Hail D, Soni A, Vishnu N, Bompada P, De Marinis Y, Groop L, Shoshan-Barmatz V, Renström E, Wollheim CB, Salehi A.

Cell Metab. 2019 Jan 8;29(1):64-77.e6. doi: 10.1016/j.cmet.2018.09.008. Epub 2018 Oct 4.

3.

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.

Taneera J, Prasad RB, Dhaiban S, Mohammed AK, Haataja L, Arvan P, Hamad M, Groop L, Wollheim CB.

Mol Cell Endocrinol. 2018 Sep 5;472:10-17. doi: 10.1016/j.mce.2018.06.003. Epub 2018 Jun 8.

PMID:
29890211
4.

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Andersson LE, Shcherbina L, Al-Majdoub M, Vishnu N, Arroyo CB, Aste Carrara J, Wollheim CB, Fex M, Mulder H, Wierup N, Spégel P.

Diabetes. 2018 Mar;67(3):372-384. doi: 10.2337/db16-1441. Epub 2017 Dec 11.

5.

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.

Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR.

Hum Mol Genet. 2018 Jan 15;27(2):406. doi: 10.1093/hmg/ddx402. No abstract available.

PMID:
29186426
6.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

7.

Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production.

Tubbs E, Axelsson AS, Vial G, Wollheim CB, Rieusset J, Rosengren AH.

Mol Cell Endocrinol. 2018 Feb 5;461:205-214. doi: 10.1016/j.mce.2017.09.016. Epub 2017 Sep 18.

PMID:
28923347
8.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477.

PMID:
28615356
9.

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH.

Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652.

10.

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.

Ofori JK, Salunkhe VA, Bagge A, Vishnu N, Nagao M, Mulder H, Wollheim CB, Eliasson L, Esguerra JL.

Sci Rep. 2017 Mar 23;7:44986. doi: 10.1038/srep44986.

11.

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

Shcherbina L, Edlund A, Esguerra JL, Abels M, Zhou Y, Ottosson-Laakso E, Wollheim CB, Hansson O, Eliasson L, Wierup N.

Mol Cell Endocrinol. 2017 May 15;447:52-60. doi: 10.1016/j.mce.2017.02.027. Epub 2017 Feb 24.

PMID:
28237718
12.

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim CB, Lee IK, Park KS.

Exp Mol Med. 2017 Feb 3;49(2):e291. doi: 10.1038/emm.2016.157. Review.

13.

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Pournourmohammadi S, Grimaldi M, Stridh MH, Lavallard V, Waagepetersen HS, Wollheim CB, Maechler P.

Int J Biochem Cell Biol. 2017 Jul;88:220-225. doi: 10.1016/j.biocel.2017.01.012. Epub 2017 Jan 27.

PMID:
28137482
14.

Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.

Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.

FASEB J. 2016 Dec;30(12):3979-3988. Epub 2016 Aug 26.

PMID:
27565711
15.

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2016 Aug;65(8):2462. doi: 10.2337/db16-ec08a. No abstract available. Update in: Diabetes. 2018 Nov;67(11):2479-2480.

16.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N.

Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.

PMID:
27338624
17.

Physiology: Microbial signals to the brain control weight.

Trajkovski M, Wollheim CB.

Nature. 2016 Jun 9;534(7606):185-7. doi: 10.1038/534185a. No abstract available.

PMID:
27279209
18.

Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.

Prasad RB, Lessmark A, Almgren P, Kovacs G, Hansson O, Oskolkov N, Vitai M, Ladenvall C, Kovacs P, Fadista J, Lachmann M, Zhou Y, Sonestedt E, Poon W, Wollheim CB, Orho-Melander M, Stumvoll M, Tuomi T, Pääbo S, Koranyi L, Groop L.

Diabetologia. 2016 Aug;59(8):1702-13. doi: 10.1007/s00125-016-3973-9. Epub 2016 May 7.

PMID:
27155871
19.

Is zinc an intra-islet regulator of glucagon secretion?

Ishihara H, Wollheim CB.

Diabetol Int. 2016 Feb 27;7(2):106-110. doi: 10.1007/s13340-016-0259-x. eCollection 2016 Jun.

20.

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function.

Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC.

J Biol Chem. 2016 Mar 18;291(12):6146-57. doi: 10.1074/jbc.M115.685750. Epub 2016 Jan 20.

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