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Items: 1 to 20 of 84


Nonspecificity in a nonimmune human scFv repertoire.

Kelly RL, Zhao J, Le D, Wittrup KD.

MAbs. 2017 Oct;9(7):1029-1035. doi: 10.1080/19420862.2017.1356528. Epub 2017 Sep 14.


Chaperone proteins as single component reagents to assess antibody nonspecificity.

Kelly RL, Geoghegan JC, Feldman J, Jain T, Kauke M, Le D, Zhao J, Wittrup KD.

MAbs. 2017 Oct;9(7):1036-1040. doi: 10.1080/19420862.2017.1356529. Epub 2017 Jul 26.


An engineered protein antagonist of K-Ras/B-Raf interaction.

Kauke MJ, Traxlmayr MW, Parker JA, Kiefer JD, Knihtila R, McGee J, Verdine G, Mattos C, Wittrup KD.

Sci Rep. 2017 Jul 19;7(1):5831. doi: 10.1038/s41598-017-05889-7.


Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.

Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD.

Nucleic Acids Res. 2017 Jul 27;45(13):7602-7614. doi: 10.1093/nar/gkx546.


Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors.

Smith TT, Moffett HF, Stephan SB, Opel CF, Dumigan AG, Jiang X, Pillarisetty VG, Pillai SPS, Wittrup KD, Stephan MT.

J Clin Invest. 2017 Jun 1;127(6):2176-2191. doi: 10.1172/JCI87624. Epub 2017 Apr 24.


Biophysical properties of the clinical-stage antibody landscape.

Jain T, Sun T, Durand S, Hall A, Houston NR, Nett JH, Sharkey B, Bobrowicz B, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Baruah H, Gray LT, Krauland EM, Xu Y, Vásquez M, Wittrup KD.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):944-949. doi: 10.1073/pnas.1616408114. Epub 2017 Jan 17.


Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers.

Green DJ, Frayo SL, Lin Y, Hamlin DK, Fisher DR, Frost SH, Kenoyer AL, Hylarides MD, Gopal AK, Gooley TA, Orozco JJ, Till BG, O'Steen S, Orcutt KD, Wilbur DS, Wittrup KD, Press OW.

Cancer Res. 2016 Nov 15;76(22):6669-6679. doi: 10.1158/0008-5472.CAN-16-0571. Epub 2016 Sep 2.


Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.

Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ.

Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24.


Target-independent variable region mediated effects on antibody clearance can be FcRn independent.

Kelly RL, Yu Y, Sun T, Caffry I, Lynaugh H, Brown M, Jain T, Xu Y, Wittrup KD.

MAbs. 2016 Oct;8(7):1269-1275. Epub 2016 Sep 9.


Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library.

Traxlmayr MW, Kiefer JD, Srinivas RR, Lobner E, Tisdale AW, Mehta NK, Yang NJ, Tidor B, Wittrup KD.

J Biol Chem. 2016 Oct 21;291(43):22496-22508. Epub 2016 Aug 30.


Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions.

de Picciotto S, Dickson PM, Traxlmayr MW, Marques BS, Socher E, Zhao S, Cheung S, Kiefer JD, Wand AJ, Griffith LG, Imperiali B, Wittrup KD.

J Mol Biol. 2016 Oct 9;428(20):4228-4241. doi: 10.1016/j.jmb.2016.07.004. Epub 2016 Jul 21.


Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).

Singh AP, Maass KF, Betts AM, Wittrup KD, Kulkarni C, King LE, Khot A, Shah DK.

AAPS J. 2016 Jul;18(4):861-75. doi: 10.1208/s12248-016-9904-3. Epub 2016 Mar 30.


Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.

Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM.

Science. 2016 Mar 4;351(6277):1078-83. doi: 10.1126/science.aad5788. Epub 2016 Feb 18.


Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design.

Maass KF, Kulkarni C, Betts AM, Wittrup KD.

AAPS J. 2016 May;18(3):635-46. doi: 10.1208/s12248-016-9892-3. Epub 2016 Feb 24.


Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity ⁸⁶Y- or ¹⁷⁷Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates.

Cheal SM, Xu H, Guo HF, Lee SG, Punzalan B, Chalasani S, Fung EK, Jungbluth A, Zanzonico PB, Carrasquillo JA, O'Donoghue J, Smith-Jones PM, Wittrup KD, Cheung NK, Larson SM.

Eur J Nucl Med Mol Imaging. 2016 May;43(5):925-37. doi: 10.1007/s00259-015-3254-8. Epub 2015 Nov 24.


A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin.

Maass KF, Kulkarni C, Quadir MA, Hammond PT, Betts AM, Wittrup KD.

J Pharm Sci. 2015 Dec;104(12):4409-4416. doi: 10.1002/jps.24631. Epub 2015 Sep 7.


A switchable yeast display/secretion system.

Van Deventer JA, Kelly RL, Rajan S, Wittrup KD, Sidhu SS.

Protein Eng Des Sel. 2015 Oct;28(10):317-25. doi: 10.1093/protein/gzv043. Epub 2015 Sep 1.


High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice.

Kelly RL, Sun T, Jain T, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Vásquez M, Wittrup KD, Xu Y.

MAbs. 2015;7(4):770-7. doi: 10.1080/19420862.2015.1043503.


Antibody-mediated neutralization of perfringolysin o for intracellular protein delivery.

Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD.

Mol Pharm. 2015 Jun 1;12(6):1992-2000. doi: 10.1021/mp500797n. Epub 2015 May 4.


Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD.

Cancer Cell. 2015 Apr 13;27(4):489-501. doi: 10.1016/j.ccell.2015.03.004.

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