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Items: 1 to 20 of 360

1.

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Vlot AHC, de Witte WEA, Danhof M, van der Graaf PH, van Westen GJP, de Lange ECM.

AAPS J. 2017 Dec 4;20(1):11. doi: 10.1208/s12248-017-0172-7.

PMID:
29204742
2.

Evidence for chemical and electronic non-uniformities in the formation of the interface of RbF-treated Cu(In,Ga)Se2 with CdS.

Nicoara N, Kunze T, Jackson P, Hariskos D, Félix Duarte R, Wilks RG, Witte W, Bär M, Sadewasser S.

ACS Appl Mater Interfaces. 2017 Nov 27. doi: 10.1021/acsami.7b12448. [Epub ahead of print]

PMID:
29178776
3.

From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.

Nederpelt I, Kuzikov M, de Witte WEA, Schnider P, Tuijt B, Gul S, IJzerman AP, de Lange ECM, Heitman LH.

Sci Rep. 2017 Oct 26;7(1):14169. doi: 10.1038/s41598-017-14257-4.

4.

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC.

Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Review.

PMID:
28933618
5.

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation.

de Witte WEA, Vauquelin G, van der Graaf PH, de Lange ECM.

Eur J Pharm Sci. 2017 Nov 15;109S:S83-S89. doi: 10.1016/j.ejps.2017.05.024. Epub 2017 May 12.

6.

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF.

Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Review.

PMID:
28412474
7.

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy.

Bot I, Ortiz Zacarías NV, de Witte WE, de Vries H, van Santbrink PJ, van der Velden D, Kröner MJ, van der Berg DJ, Stamos D, de Lange EC, Kuiper J, IJzerman AP, Heitman LH.

Sci Rep. 2017 Mar 3;7(1):52. doi: 10.1038/s41598-017-00104-z.

8.

Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Larsen J, Stegger M, Andersen PS, Petersen A, Larsen AR, Westh H, Agersø Y, Fetsch A, Kraushaar B, Käsbohrer A, Feβler AT, Schwarz S, Cuny C, Witte W, Butaye P, Denis O, Haenni M, Madec JY, Jouy E, Laurent F, Battisti A, Franco A, Alba P, Mammina C, Pantosti A, Monaco M, Wagenaar JA, de Boer E, van Duijkeren E, Heck M, Domínguez L, Torres C, Zarazaga M, Price LB, Skov RL.

Clin Infect Dis. 2016 Nov 15;63(10):1349-1352. Epub 2016 Sep 20.

9.

Molecular Epidemiology of Staphylococcus aureus in the General Population in Northeast Germany: Results of the Study of Health in Pomerania (SHIP-TREND-0).

Holtfreter S, Grumann D, Balau V, Barwich A, Kolata J, Goehler A, Weiss S, Holtfreter B, Bauerfeind SS, Döring P, Friebe E, Haasler N, Henselin K, Kühn K, Nowotny S, Radke D, Schulz K, Schulz SR, Trübe P, Vu CH, Walther B, Westphal S, Cuny C, Witte W, Völzke H, Grabe HJ, Kocher T, Steinmetz I, Bröker BM.

J Clin Microbiol. 2016 Nov;54(11):2774-2785. Epub 2016 Sep 7.

10.

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

de Witte WE, Danhof M, van der Graaf PH, de Lange EC.

Trends Pharmacol Sci. 2016 Oct;37(10):831-42. doi: 10.1016/j.tips.2016.06.008. Epub 2016 Jul 6. Review.

PMID:
27394919
11.

Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community.

Mehraj J, Witte W, Akmatov MK, Layer F, Werner G, Krause G.

Curr Top Microbiol Immunol. 2016;398:55-87. doi: 10.1007/82_2016_497. Review.

PMID:
27370344
12.

Whole-Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe.

Aanensen DM, Feil EJ, Holden MT, Dordel J, Yeats CA, Fedosejev A, Goater R, Castillo-Ramírez S, Corander J, Colijn C, Chlebowicz MA, Schouls L, Heck M, Pluister G, Ruimy R, Kahlmeter G, Åhman J, Matuschek E, Friedrich AW, Parkhill J, Bentley SD, Spratt BG, Grundmann H; European SRL Working Group.

MBio. 2016 May 5;7(3). pii: e00444-16. doi: 10.1128/mBio.00444-16.

13.

Occurrence of cfr-mediated multiresistance in staphylococci from veal calves and pigs, from humans at the corresponding farms, and from veterinarians and their family members.

Cuny C, Arnold P, Hermes J, Eckmanns T, Mehraj J, Schoenfelder S, Ziebuhr W, Zhao Q, Wang Y, Feßler AT, Krause G, Schwarz S, Witte W.

Vet Microbiol. 2017 Feb;200:88-94. doi: 10.1016/j.vetmic.2016.04.002. Epub 2016 Apr 6.

PMID:
27102205
14.

Persistence of nasal colonisation with methicillin resistant Staphylococcus aureus CC398 among participants of veterinary conferences and occurrence among their household members: A prospective cohort study, Germany 2008-2014.

Walter J, Espelage W, Adlhoch C, Cuny C, Schink S, Jansen A, Witte W, Eckmanns T, Hermes J.

Vet Microbiol. 2017 Feb;200:13-18. doi: 10.1016/j.vetmic.2016.03.015. Epub 2016 Mar 26.

PMID:
27039883
15.

Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398.

Jung P, Abdelbary MM, Kraushaar B, Fetsch A, Geisel J, Herrmann M, Witte W, Cuny C, Bischoff M.

Vet Microbiol. 2017 Feb;200:46-51. doi: 10.1016/j.vetmic.2016.02.015. Epub 2016 Feb 23.

PMID:
26923248
16.

MRSA in equine hospitals and its significance for infections in humans.

Cuny C, Witte W.

Vet Microbiol. 2017 Feb;200:59-64. doi: 10.1016/j.vetmic.2016.01.013. Epub 2016 Jan 21. Review.

PMID:
26869097
17.

Methicillin-resistant Staphylococcus aureus from infections in horses in Germany are frequent colonizers of veterinarians but rare among MRSA from infections in humans.

Cuny C, Abdelbary MMH, Köck R, Layer F, Scheidemann W, Werner G, Witte W.

One Health. 2015 Dec 12;2:11-17. doi: 10.1016/j.onehlt.2015.11.004. eCollection 2016 Dec.

18.

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.

Dubois VF, de Witte WE, Visser SA, Danhof M, Della Pasqua O; Cardiovascular Safety Project Team; TI Pharma PKPD Platform.

Pharm Res. 2016 Jan;33(1):40-51. doi: 10.1007/s11095-015-1760-9. Epub 2015 Nov 9.

19.

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC.

Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Review.

PMID:
26484747
20.

Veterinarians Visiting Swine Farms Are at High Risk for Colonization With Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Walter J, Espelage W, Cuny C, Jansen A, Witte W, Eckmanns T, Hermes J.

Clin Infect Dis. 2016 Jan 1;62(1):126-8. doi: 10.1093/cid/civ752. Epub 2015 Sep 3. No abstract available.

PMID:
26338785

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