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Items: 1 to 20 of 35


Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.

Faraji F, Hu Y, Yang HH, Lee MP, Winkler GS, Hafner M, Hunter KW.

PLoS Genet. 2016 Jan 25;12(1):e1005820. doi: 10.1371/journal.pgen.1005820. eCollection 2016 Jan 25.


Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Hage N, Howard T, Phillips C, Brassington C, Overman R, Debreczeni J, Gellert P, Stolnik S, Winkler GS, Falcone FH.

Sci Adv. 2015 Aug 14;1(7):e1500315. doi: 10.1126/sciadv.1500315. eCollection 2015 Aug 14.


Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown.

Loczenski Rose V, Shubber S, Sajeesh S, Spain SG, Puri S, Allen S, Lee DK, Winkler GS, Mantovani G.

Biomacromolecules. 2015 Nov 9;16(11):3480-90. doi: 10.1021/acs.biomac.5b00898. Epub 2015 Oct 7.


Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.

Jadhav GP, Kaur I, Maryati M, Airhihen B, Fischer PM, Winkler GS.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4219-24. doi: 10.1016/j.bmcl.2015.07.095. Epub 2015 Aug 6.


The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

Maryati M, Airhihen B, Winkler GS.

Biochem J. 2015 Jul 1;469(1):169-76. doi: 10.1042/BJ20150304. Epub 2015 May 6.


Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag.

Hage N, Renshaw JG, Winkler GS, Gellert P, Stolnik S, Falcone FH.

Protein Expr Purif. 2015 Feb;106:25-30. doi: 10.1016/j.pep.2014.10.009. Epub 2014 Oct 25.


Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex.

Winkler GS, Balacco DL.

Front Genet. 2013 Dec 23;4:296. doi: 10.3389/fgene.2013.00296. Review.


A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.

Maryati M, Kaur I, Jadhav GP, Olotu-Umoren L, Oveh B, Hashmi L, Fischer PM, Winkler GS.

Nucleic Acids Res. 2014 Mar;42(5):e30. doi: 10.1093/nar/gkt972. Epub 2013 Oct 28.


Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.

Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK, Heery DM.

BMC Cancer. 2013 Jan 29;13:37. doi: 10.1186/1471-2407-13-37.


RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

Wahle E, Winkler GS.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.


The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

Doidge R, Mittal S, Aslam A, Winkler GS.

PLoS One. 2012;7(12):e51331. doi: 10.1371/journal.pone.0051331. Epub 2012 Dec 7.


Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.

Doidge R, Mittal S, Aslam A, Winkler GS.

Biochem Soc Trans. 2012 Aug;40(4):896-901. doi: 10.1042/BST20120074. Review.


The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.

Mittal S, Aslam A, Doidge R, Medica R, Winkler GS.

Mol Biol Cell. 2011 Mar 15;22(6):748-58. doi: 10.1091/mbc.E10-11-0898. Epub 2011 Jan 13.


The mammalian anti-proliferative BTG/Tob protein family.

Winkler GS.

J Cell Physiol. 2010 Jan;222(1):66-72. doi: 10.1002/jcp.21919. Review.


The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

Aslam A, Mittal S, Koch F, Andrau JC, Winkler GS.

Mol Biol Cell. 2009 Sep;20(17):3840-50. doi: 10.1091/mbc.E09-02-0146. Epub 2009 Jul 15.


E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity.

Huang A, de Jong RN, Wienk H, Winkler GS, Timmers HT, Boelens R.

J Mol Biol. 2009 Jan 16;385(2):507-19. doi: 10.1016/j.jmb.2008.10.044. Epub 2008 Nov 1.


Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.

Mulder KW, Inagaki A, Cameroni E, Mousson F, Winkler GS, De Virgilio C, Collart MA, Timmers HT.

Genetics. 2007 May;176(1):181-92.


Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.

Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT.

EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15.


Menin links estrogen receptor activation to histone H3K4 trimethylation.

Dreijerink KM, Mulder KW, Winkler GS, Höppener JW, Lips CJ, Timmers HT.

Cancer Res. 2006 May 1;66(9):4929-35.


Structure-based approaches to create new E2-E3 enzyme pairs.

Winkler GS, Timmers HT.

Methods Enzymol. 2005;399:355-66.


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