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Items: 18


Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child.

Wijeyesekera A, Wagner J, De Goffau M, Thurston S, Rodrigues Sabino A, Zaher S, White D, Ridout J, Peters MJ, Ramnarayan P, Branco RG, Torok ME, Valla F, Meyer R, Klein N, Frost G, Parkhill J, Holmes E, Pathan N.

Crit Care Med. 2019 Sep;47(9):e727-e734. doi: 10.1097/CCM.0000000000003841.


Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial.

Parkinson JRC, Wijeyesekera AD, Hyde MJ, Singhal A, Lucas A, Holmes E, Modi N.

BMJ Paediatr Open. 2017 Nov 1;1(1):e000192. doi: 10.1136/bmjpo-2017-000192. eCollection 2017.


Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology.

Chekmeneva E, Dos Santos Correia G, Chan Q, Wijeyesekera A, Tin A, Young JH, Elliott P, Nicholson JK, Holmes E.

J Proteome Res. 2017 Apr 7;16(4):1646-1658. doi: 10.1021/acs.jproteome.6b01003. Epub 2017 Mar 14.


New technologies - new insights into the pathogenesis of hepatic encephalopathy.

Baker L, Lanz B, Andreola F, Ampuero J, Wijeyesekera A, Holmes E, Deutz N.

Metab Brain Dis. 2016 Dec;31(6):1259-1267. Epub 2016 Sep 30. Review.


Development of a Pipeline for Exploratory Metabolic Profiling of Infant Urine.

Jackson F, Georgakopoulou N, Kaluarachchi M, Kyriakides M, Andreas N, Przysiezna N, Hyde MJ, Modi N, Nicholson JK, Wijeyesekera A, Holmes E.

J Proteome Res. 2016 Sep 2;15(9):3432-40. doi: 10.1021/acs.jproteome.6b00234. Epub 2016 Aug 23.


(1)H NMR Spectroscopy of Fecal Extracts Enables Detection of Advanced Colorectal Neoplasia.

Amiot A, Dona AC, Wijeyesekera A, Tournigand C, Baumgaertner I, Lebaleur Y, Sobhani I, Holmes E.

J Proteome Res. 2015 Sep 4;14(9):3871-81. doi: 10.1021/acs.jproteome.5b00277. Epub 2015 Aug 7.


The promise of metabolic phenotyping in gastroenterology and hepatology.

Holmes E, Wijeyesekera A, Taylor-Robinson SD, Nicholson JK.

Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):458-71. doi: 10.1038/nrgastro.2015.114. Epub 2015 Jul 21. Review.


Multiplatform characterization of dynamic changes in breast milk during lactation.

Andreas NJ, Hyde MJ, Gomez-Romero M, Lopez-Gonzalvez MA, Villaseñor A, Wijeyesekera A, Barbas C, Modi N, Holmes E, Garcia-Perez I.

Electrophoresis. 2015 Sep;36(18):2269-2285. doi: 10.1002/elps.201500011. Epub 2015 Jun 25.


Urinary metabolic signatures of human adiposity.

Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK.

Sci Transl Med. 2015 Apr 29;7(285):285ra62. doi: 10.1126/scitranslmed.aaa5680. Epub 2015 Apr 29.


Metabolic Profiling of Children Undergoing Surgery for Congenital Heart Disease.

Correia GD, Wooi Ng K, Wijeyesekera A, Gala-Peralta S, Williams R, MacCarthy-Morrogh S, Jiménez B, Inwald D, Macrae D, Frost G, Holmes E, Pathan N.

Crit Care Med. 2015 Jul;43(7):1467-76. doi: 10.1097/CCM.0000000000000982.


Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.

Ladep NG, Dona AC, Lewis MR, Crossey MM, Lemoine M, Okeke E, Shimakawa Y, Duguru M, Njai HF, Fye HK, Taal M, Chetwood J, Kasstan B, Khan SA, Garside DA, Wijeyesekera A, Thillainayagam AV, Banwat E, Thursz MR, Nicholson JK, Njie R, Holmes E, Taylor-Robinson SD.

Hepatology. 2014 Oct;60(4):1291-301. doi: 10.1002/hep.27264. Epub 2014 Aug 25.


Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome.

Klootwijk ED, Reichold M, Helip-Wooley A, Tolaymat A, Broeker C, Robinette SL, Reinders J, Peindl D, Renner K, Eberhart K, Assmann N, Oefner PJ, Dettmer K, Sterner C, Schroeder J, Zorger N, Witzgall R, Reinhold SW, Stanescu HC, Bockenhauer D, Jaureguiberry G, Courtneidge H, Hall AM, Wijeyesekera AD, Holmes E, Nicholson JK, O'Brien K, Bernardini I, Krasnewich DM, Arcos-Burgos M, Izumi Y, Nonoguchi H, Jia Y, Reddy JK, Ilyas M, Unwin RJ, Gahl WA, Warth R, Kleta R.

N Engl J Med. 2014 Jan 9;370(2):129-38. doi: 10.1056/NEJMoa1307581.


Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure.

Stamler J, Brown IJ, Yap IK, Chan Q, Wijeyesekera A, Garcia-Perez I, Chadeau-Hyam M, Ebbels TM, De Iorio M, Posma J, Daviglus ML, Carnethon M, Holmes E, Nicholson JK, Elliott P; INTERMAP Research Group.

Hypertension. 2013 Dec;62(6):1074-80. doi: 10.1161/HYPERTENSIONAHA.113.01810. Epub 2013 Oct 7.


Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.

Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E.

J Proteome Res. 2012 Sep 7;11(9):4425-35. doi: 10.1021/pr2012544. Epub 2012 Aug 28.


Metabotyping of long-lived mice using 1H NMR spectroscopy.

Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJ.

J Proteome Res. 2012 Apr 6;11(4):2224-35. doi: 10.1021/pr2010154. Epub 2012 Feb 27.


Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.

Wijeyesekera A, Clarke PA, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IK, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JK.

Anal Methods. 2012 Jan 1;4(1):65-72.


Relation of urinary calcium and magnesium excretion to blood pressure: The International Study Of Macro- And Micro-nutrients And Blood Pressure and The International Cooperative Study On Salt, Other Factors, And Blood Pressure.

Kesteloot H, Tzoulaki I, Brown IJ, Chan Q, Wijeyesekera A, Ueshima H, Zhao L, Dyer AR, Unwin RJ, Stamler J, Elliott P.

Am J Epidemiol. 2011 Jul 1;174(1):44-51. doi: 10.1093/aje/kwr049. Epub 2011 May 30.


Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.

Yap IK, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels T, De Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E.

J Proteome Res. 2010 Dec 3;9(12):6647-54. doi: 10.1021/pr100798r. Epub 2010 Nov 2.

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