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Items: 1 to 20 of 269


The mechanistic implications of gene expression studies in SSc: Insights from Systems Biology.

Taroni JN, Mahoney JM, Whitfield ML.

Curr Treatm Opt Rheumatol. 2017 Sep;3(3):181-192. doi: 10.1007/s40674-017-0072-0. Epub 2017 Jul 29. No abstract available.


Avian thermoregulation in the heat: phylogenetic variation among avian orders in evaporative cooling capacity and heat tolerance.

Smit B, Whitfield MC, Talbot WA, Gerson AR, McKechnie AE, Wolf BO.

J Exp Biol. 2018 Mar 19;221(Pt 6). pii: jeb174870. doi: 10.1242/jeb.174870.


Comprehensive overview of murine epididymal mononuclear phagocytes and lymphocytes: Unexpected populations arise.

Voisin A, Whitfield M, Damon-Soubeyrand C, Goubely C, Henry-Berger J, Saez F, Kocer A, Drevet JR, Guiton R.

J Reprod Immunol. 2018 Apr;126:11-17. doi: 10.1016/j.jri.2018.01.003. Epub 2018 Jan 31.


Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.

Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML.

J Invest Dermatol. 2018 Jan 31. pii: S0022-202X(18)30023-X. doi: 10.1016/j.jid.2018.01.006. [Epub ahead of print]


Feature Specific Quantile Normalization Enables Cross-Platform Classification of Molecular Subtypes using Gene Expression Data.

Franks JM, Cai G, Whitfield ML.

Bioinformatics. 2018 Jan 17. doi: 10.1093/bioinformatics/bty026. [Epub ahead of print]


Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.

Messemaker TC, Chadli L, Cai G, Goelela VS, Boonstra M, Dorjée AL, Andersen SN, Mikkers HMM, van 't Hof P, Mei H, Distler O, Draisma HHM, Johnson ME, Orzechowski NM, Simms RW, Toes REM, Aarbiou J, Huizinga TW, Whitfield ML, DeGroot J, de Vries-Bouwstra J, Kurreeman F.

J Invest Dermatol. 2018 Apr;138(4):826-835. doi: 10.1016/j.jid.2017.09.053. Epub 2017 Nov 24.


Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.

Martyanov V, Kim GJ, Hayes W, Du S, Ganguly BJ, Sy O, Lee SK, Bogatkevich GS, Schieven GL, Schiopu E, Marangoni RG, Goldin J, Whitfield ML, Varga J.

PLoS One. 2017 Nov 9;12(11):e0187580. doi: 10.1371/journal.pone.0187580. eCollection 2017.


Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial.

Gordon JK, Martyanov V, Franks JM, Bernstein EJ, Szymonifka J, Magro C, Wildman HF, Wood TA, Whitfield ML, Spiera RF.

Arthritis Rheumatol. 2018 Feb;70(2):308-316. doi: 10.1002/art.40358. Epub 2017 Dec 29.


Dyslipidemia alters sperm maturation and capacitation in LXR-null mice.

Whitfield M, Guiton R, Rispal J, Acar N, Kocer A, Drevet JR, Saez F.

Reproduction. 2017 Dec;154(6):827-842. doi: 10.1530/REP-17-0467. Epub 2017 Oct 2.


Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature.

Derrett-Smith EC, Martyanov V, Chighizola CB, Moinzadeh P, Campochiaro C, Khan K, Wood TA, Meroni PL, Abraham DJ, Ong VH, Lafyatis R, Whitfield ML, Denton CP.

Arthritis Res Ther. 2017 Jul 4;19(1):156. doi: 10.1186/s13075-017-1360-7.


Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment.

Driesen M, Kondo Y, de Jong BC, Torrea G, Asnong S, Desmaretz C, Mostofa KSM, Tahseen S, Whitfield MG, Cirillo DM, Miotto P, Cabibbe AM, Rigouts L.

Clin Microbiol Infect. 2018 Jan;24(1):60-64. doi: 10.1016/j.cmi.2017.05.026. Epub 2017 Jun 3.


Population effect model identifies gene expression predictors of survival outcomes in lung adenocarcinoma for both Caucasian and Asian patients.

Cai G, Xiao F, Cheng C, Li Y, Amos CI, Whitfield ML.

PLoS One. 2017 Apr 20;12(4):e0175850. doi: 10.1371/journal.pone.0175850. eCollection 2017.


A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.

Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML.

Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1.


Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.

Steinberg SM, Shabaneh TB, Zhang P, Martyanov V, Li Z, Malik BT, Wood TA, Boni A, Molodtsov A, Angeles CV, Curiel TJ, Whitfield ML, Turk MJ.

Cancer Res. 2017 Apr 1;77(7):1599-1610. doi: 10.1158/0008-5472.CAN-16-1755. Epub 2017 Feb 15.


Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.

Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P.

JCI Insight. 2016 Dec 22;1(21):e89073. doi: 10.1172/jci.insight.89073.


A Functional Genomic Meta-Analysis of Clinical Trials in Systemic Sclerosis: Toward Precision Medicine and Combination Therapy.

Taroni JN, Martyanov V, Mahoney JM, Whitfield ML.

J Invest Dermatol. 2017 May;137(5):1033-1041. doi: 10.1016/j.jid.2016.12.007. Epub 2016 Dec 21.


A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.

Lyons SM, Cunningham CH, Welch JD, Groh B, Guo AY, Wei B, Whitfield ML, Xiong Y, Marzluff WF.

Nucleic Acids Res. 2016 Nov 2;44(19):9190-9205. Epub 2016 Jul 8.


Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry.

Canovic EP, Qing B, Mijailovic AS, Jagielska A, Whitfield MJ, Kelly E, Turner D, Sahin M, Van Vliet KJ.

J Vis Exp. 2016 Sep 6;(115). doi: 10.3791/54201.


Avian thermoregulation in the heat: evaporative cooling capacity in an archetypal desert specialist, Burchell's sandgrouse (Pterocles burchelli).

McKechnie AE, Smit B, Whitfield MC, Noakes MJ, Talbot WA, Garcia M, Gerson AR, Wolf BO.

J Exp Biol. 2016 Aug 1;219(Pt 15):2409. doi: 10.1242/jeb.146563. No abstract available.


Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.

Whitfield MG, Streicher EM, Dolby T, Simpson JA, Sampson SL, Van Helden PD, Van Rie A, Warren RM.

Tuberculosis (Edinb). 2016 Jul;99:128-30. doi: 10.1016/ Epub 2016 May 30.

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