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Items: 1 to 20 of 137

1.

Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR.

White AD, Jean-Alphonse FG, Fang F, Peña KA, Liu S, König GM, Inoue A, Aslanoglou D, Gellman SH, Kostenis E, Xiao K, Vilardaga JP.

Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7455-7460. doi: 10.1073/pnas.1918158117. Epub 2020 Mar 17.

PMID:
32184323
2.

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD.

ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634. doi: 10.1021/acsmedchemlett.9b00365. eCollection 2019 Dec 12.

PMID:
31857838
3.

PTH/PTHrP Receptor Signaling, Allostery, and Structures.

Sutkeviciute I, Clark LJ, White AD, Gardella TJ, Vilardaga JP.

Trends Endocrinol Metab. 2019 Nov;30(11):860-874. doi: 10.1016/j.tem.2019.07.011. Review.

PMID:
31699241
4.

Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism.

Liu S, Jean-Alphonse FG, White AD, Wootten D, Sexton PM, Gardella TJ, Vilardaga JP, Gellman SH.

J Am Chem Soc. 2019 Sep 18;141(37):14486-14490. doi: 10.1021/jacs.9b04179. Epub 2019 Sep 9.

PMID:
31496241
5.

The Use of Closure Devices for Aortic Stent-Graft Insertion: Outcomes Following a Paradigm Shift to Percutaneous Access in a Tertiary Vascular Center.

White AD, Hazar C, Jarosz D, Walker P, Shaw D, Tingerides C.

Vasc Endovascular Surg. 2019 Oct;53(7):536-540. doi: 10.1177/1538574419858829. Epub 2019 Jun 24.

PMID:
31234730
6.

Structure and dynamics of the active human parathyroid hormone receptor-1.

Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y.

Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942.

7.

Author Correction: The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.

Tanner R, O'Shea MK, White AD, Müller J, Harrington-Kandt R, Matsumiya M, Dennis MJ, Parizotto EA, Harris S, Stylianou E, Naranbhai V, Bettencourt P, Drakesmith H, Sharpe S, Fletcher HA, McShane H.

Sci Rep. 2019 Apr 3;9(1):5596. doi: 10.1038/s41598-019-41387-8.

8.

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques.

Sibley L, Gooch K, Wareham A, Gray S, Chancellor A, Dowall S, Bate S, Marriott A, Dennis M, White AD, Marsh PD, Fletcher H, Sharpe S.

Sci Rep. 2019 Mar 4;9(1):3340. doi: 10.1038/s41598-019-39819-6.

9.

Regarding "Long-Term Evaluation of Percutaneous Groin Access for EVAR".

White AD, Hazar C, Jarosz D, Walker P, Tingerides C.

Cardiovasc Intervent Radiol. 2019 May;42(5):788. doi: 10.1007/s00270-019-02174-0. Epub 2019 Feb 7. No abstract available.

PMID:
30734068
10.

Ca2+ allostery in PTH-receptor signaling.

White AD, Fang F, Jean-Alphonse FG, Clark LJ, An HJ, Liu H, Zhao Y, Reynolds SL, Lee S, Xiao K, Sutkeviciute I, Vilardaga JP.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3294-3299. doi: 10.1073/pnas.1814670116. Epub 2019 Feb 4.

11.

Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis.

Naim N, White AD, Reece JM, Wankhede M, Zhang X, Vilardaga JP, Altschuler DL.

J Biol Chem. 2019 Jan 25;294(4):1095-1103. doi: 10.1074/jbc.AC118.004905. Epub 2018 Dec 17.

12.

Encoding and selecting coarse-grain mapping operators with hierarchical graphs.

Chakraborty M, Xu C, White AD.

J Chem Phys. 2018 Oct 7;149(13):134106. doi: 10.1063/1.5040114.

PMID:
30292213
13.

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

Focken T, Chowdhury S, Zenova A, Grimwood ME, Chabot C, Sheng T, Hemeon I, Decker SM, Wilson M, Bichler P, Jia Q, Sun S, Young C, Lin S, Goodchild SJ, Shuart NG, Chang E, Xie Z, Li B, Khakh K, Bankar G, Waldbrook M, Kwan R, Nelkenbrecher K, Karimi Tari P, Chahal N, Sojo L, Robinette CL, White AD, Chen CA, Zhang Y, Pang J, Chang JH, Hackos DH, Johnson JP Jr, Cohen CJ, Ortwine DF, Sutherlin DP, Dehnhardt CM, Safina BS.

J Med Chem. 2018 Jun 14;61(11):4810-4831. doi: 10.1021/acs.jmedchem.7b01826. Epub 2018 May 23.

PMID:
29737846
14.

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.

Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S.

Front Physiol. 2018 Feb 9;9:51. doi: 10.3389/fphys.2018.00051. eCollection 2018.

15.

Multiscale Kinetic Modeling Reveals an Ensemble of Cl-/H+ Exchange Pathways in ClC-ec1 Antiporter.

Mayes HB, Lee S, White AD, Voth GA, Swanson JMJ.

J Am Chem Soc. 2018 Feb 7;140(5):1793-1804. doi: 10.1021/jacs.7b11463. Epub 2018 Jan 30.

16.

An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques.

Sharpe SA, White AD, Sibley L, Gleeson F, Hall GA, Basaraba RJ, McIntyre A, Clark SO, Gooch K, Marsh PD, Williams A, Dennis MJ.

PLoS One. 2017 Mar 8;12(3):e0171906. doi: 10.1371/journal.pone.0171906. eCollection 2017.

17.

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.

Tanner R, O'Shea MK, White AD, Müller J, Harrington-Kandt R, Matsumiya M, Dennis MJ, Parizotto EA, Harris S, Stylianou E, Naranbhai V, Bettencourt P, Drakesmith H, Sharpe S, Fletcher HA, McShane H.

Sci Rep. 2017 Mar 3;7:43478. doi: 10.1038/srep43478. Erratum in: Sci Rep. 2019 Apr 3;9(1):5596.

18.

Communication: Improved ab initio molecular dynamics by minimally biasing with experimental data.

White AD, Knight C, Hocky GM, Voth GA.

J Chem Phys. 2017 Jan 28;146(4):041102. doi: 10.1063/1.4974837.

PMID:
28147531
19.

The Problem with Big Data: Operating on Smaller Datasets to Bridge the Implementation Gap.

Mann RP, Mushtaq F, White AD, Mata-Cervantes G, Pike T, Coker D, Murdoch S, Hiles T, Smith C, Berridge D, Hinchliffe S, Hall G, Smye S, Wilkie RM, Lodge JP, Mon-Williams M.

Front Public Health. 2016 Dec 1;4:248. eCollection 2016.

20.

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.

Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA, Viollet B, Touyz RM, Palmer TM, Salt IP.

Mol Cell Endocrinol. 2017 Jan 15;440:44-56. doi: 10.1016/j.mce.2016.11.010. Epub 2016 Nov 11.

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