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Items: 1 to 20 of 211


Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila.

Henstridge MA, Aulsebrook L, Koyama T, Johnson TK, Whisstock JC, Tiganis T, Mirth CK, Warr CG.

Genetics. 2018 Apr;208(4):1523-1533. doi: 10.1534/genetics.117.300601. Epub 2018 Feb 13.


Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I.

Cell Death Differ. 2018 Feb 7. doi: 10.1038/s41418-018-0057-z. [Epub ahead of print]


An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy.

Westwood JA, Ellis S, Danne J, Johnson C, Oorschot V, Ramm G, Tscharke DC, Davenport AJ, Whisstock JC, Darcy PK, Kershaw MH, Slaney CY.

Oncotarget. 2017 Dec 14;8(70):115215-115229. doi: 10.18632/oncotarget.23215. eCollection 2017 Dec 29.


Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway.

Johns AR, Henstridge MA, Saligari MJ, Moore KA, Whisstock JC, Warr CG, Johnson TK.

G3 (Bethesda). 2018 Mar 2;8(3):761-769. doi: 10.1534/g3.117.300491.


X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.

Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC.

Blood Adv. 2017 May 9;1(12):766-771. doi: 10.1182/bloodadvances.2016004150. eCollection 2017 May 9.


The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang SS, Wijeyewickrema LC, Hor L, Tan S, Lameignere E, Conway EM, Blom AM, Mohlin FC, Liu X, Payne RJ, Whisstock JC, Pike RN.

J Immunol. 2017 Dec 1;199(11):3883-3891. doi: 10.4049/jimmunol.1700158. Epub 2017 Oct 23.


An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Letter.

Whisstock JC, Bird PI.

Cancer Res. 2017 Sep 15;77(18):5207. doi: 10.1158/0008-5472.CAN-17-0178. Epub 2017 Sep 6. No abstract available.


Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.

House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I.

EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14.


Homodimerization attenuates the anti-inflammatory activity of interleukin-37.

Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF.

Sci Immunol. 2017 Feb 10;2(8). pii: eaaj1548. doi: 10.1126/sciimmunol.aaj1548.


Perforin-A key (shaped) weapon in the immunological arsenal.

Spicer BA, Conroy PJ, Law RHP, Voskoboinik I, Whisstock JC.

Semin Cell Dev Biol. 2017 Dec;72:117-123. doi: 10.1016/j.semcdb.2017.07.033. Epub 2017 Jul 27. Review.


Maternal Torso-Like Coordinates Tissue Folding During Drosophila Gastrulation.

Johnson TK, Moore KA, Whisstock JC, Warr CG.

Genetics. 2017 Jul;206(3):1459-1468. doi: 10.1534/genetics.117.200576. Epub 2017 May 11.


Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.

Yang ASP, O'Neill MT, Jennison C, Lopaticki S, Allison CC, Armistead JS, Erickson SM, Rogers KL, Ellisdon AM, Whisstock JC, Tweedell RE, Dinglasan RR, Douglas DN, Kneteman NM, Boddey JA.

Cell Rep. 2017 Mar 28;18(13):3105-3116. doi: 10.1016/j.celrep.2017.03.017.


Real-time visualization of perforin nanopore assembly.

Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW.

Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6.


Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.

Conroy PJ, Law RH, Caradoc-Davies TT, Whisstock JC.

Methods. 2017 Mar 1;116:12-22. doi: 10.1016/j.ymeth.2017.01.003. Epub 2017 Jan 11. Review.


Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.

Berkowicz SR, Featherby TJ, Whisstock JC, Bird PI.

Front Behav Neurosci. 2016 Oct 25;10:196. eCollection 2016.


Smoothing a rugged protein folding landscape by sequence-based redesign.

Porebski BT, Keleher S, Hollins JJ, Nickson AA, Marijanovic EM, Borg NA, Costa MG, Pearce MA, Dai W, Zhu L, Irving JA, Hoke DE, Kass I, Whisstock JC, Bottomley SP, Webb GI, McGowan S, Buckle AM.

Sci Rep. 2016 Sep 26;6:33958. doi: 10.1038/srep33958.


Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like.

Forbes-Beadle L, Crossman T, Johnson TK, Burke R, Warr CG, Whisstock JC.

Genetics. 2016 Oct;204(2):675-681. Epub 2016 Aug 17.


Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Apr 22;6:24333. doi: 10.1038/srep24333. No abstract available.


Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.

Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI.

Mol Autism. 2016 Mar 31;7:22. doi: 10.1186/s13229-016-0079-7. eCollection 2016.

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