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Items: 1 to 20 of 62


Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission.

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED.

Circ Res. 2017 Nov 1. pii: CIRCRESAHA.117.311307. doi: 10.1161/CIRCRESAHA.117.311307. [Epub ahead of print]


Metabolic Origins of Heart Failure.

Wende AR, Brahma MK, McGinnis GR, Young ME.

JACC Basic Transl Sci. 2017 Jun;2(3):297-310. doi: 10.1016/j.jacbts.2016.11.009.


Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.

Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1098-H1108. doi: 10.1152/ajpheart.00101.2017. Epub 2017 Aug 19.


Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.

McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME.

J Mol Cell Cardiol. 2017 Sep;110:80-95. doi: 10.1016/j.yjmcc.2017.07.005. Epub 2017 Jul 20.


Diabetes-Related Cardiac Dysfunction.

Williams LJ, Nye BG, Wende AR.

Endocrinol Metab (Seoul). 2017 Jun;32(2):171-179. doi: 10.3803/EnM.2017.32.2.171. Review.


O-GlcNAcylation and cardiovascular disease.

Wright JN, Collins HE, Wende AR, Chatham JC.

Biochem Soc Trans. 2017 Apr 15;45(2):545-553. doi: 10.1042/BST20160164. Review.


My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.

Brahma MK, Pepin ME, Wende AR.

Diabetes Metab J. 2017 Feb;41(1):1-9. doi: 10.4093/dmj.2017.41.1.1. Review.


Visible and red emissive molecular beacons for optical temperature measurements and quality control in diagnostic assays utilizing temperature-dependent amplification reactions.

Fidan Z, Wende A, Resch-Genger U.

Anal Bioanal Chem. 2017 Feb;409(6):1519-1529. doi: 10.1007/s00216-016-0088-6. Epub 2016 Nov 29.


Measurements of extinct fission products in nuclear bomb debris: Determination of the yield of the Trinity nuclear test 70 y later.

Hanson SK, Pollington AD, Waidmann CR, Kinman WS, Wende AM, Miller JL, Berger JA, Oldham WJ, Selby HD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8104-8. doi: 10.1073/pnas.1602792113. Epub 2016 Jul 5.


Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.

Wende AR, Young ME, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM.

Free Radic Biol Med. 2016 Nov;100:94-107. doi: 10.1016/j.freeradbiomed.2016.05.022. Epub 2016 May 27. Review.


Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.

Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):297-305. doi: 10.1016/j.yjmcc.2015.10.015. Epub 2015 Oct 22.


Unsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity.

Wende AR.

Diabetes. 2015 Oct;64(10):3339-41. doi: 10.2337/dbi15-0001. No abstract available.


Post-translational modifications of the cardiac proteome in diabetes and heart failure.

Wende AR.

Proteomics Clin Appl. 2016 Jan;10(1):25-38. doi: 10.1002/prca.201500052. Epub 2015 Sep 14. Review.


Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.

Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H.

Basic Res Cardiol. 2015;110(4):37. doi: 10.1007/s00395-015-0495-4. Epub 2015 May 16.


Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.

Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED.

Mol Cell Biol. 2015 Mar;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22.


Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.

Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, Chatham JC, Wende AR, Yang Q, Chow CW, Martino TA, Gamble KL.

J Biol Rhythms. 2014 Aug;29(4):257-76. doi: 10.1177/0748730414543141.


Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED.

Mol Cell Biol. 2014 Sep 15;34(18):3450-60. doi: 10.1128/MCB.00426-14. Epub 2014 Jul 7.


Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

Addison O, Drummond MJ, LaStayo PC, Dibble LE, Wende AR, McClain DA, Marcus RL.

J Nutr Health Aging. 2014 May;18(5):532-8. doi: 10.1007/s12603-014-0019-1.


Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.

Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED.

FASEB J. 2014 Aug;28(8):3691-702. doi: 10.1096/fj.14-253823. Epub 2014 Apr 28.


GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.

Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED.

J Mol Cell Cardiol. 2014 Jul;72:95-103. doi: 10.1016/j.yjmcc.2014.02.011. Epub 2014 Feb 25.

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