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Items: 1 to 20 of 88

1.

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.

Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR.

Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9.

2.

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

Barratt SL, Blythe T, Ourradi K, Jarrett C, Welsh GI, Bates DO, Millar AB.

Respir Res. 2018 Jan 15;19(1):9. doi: 10.1186/s12931-017-0711-x.

3.

The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.

Sadreev II, Chen MZQ, Umezawa Y, Biktashev VN, Kemper C, Salakhieva DV, Welsh GI, Kotov NV.

Immunology. 2018 Apr;153(4):488-501. doi: 10.1111/imm.12851. Epub 2017 Nov 22.

PMID:
29030870
4.

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Østergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM.

Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29.

PMID:
28852804
5.

Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations.

Sen ES, Dean P, Yarram-Smith L, Bierzynska A, Woodward G, Buxton C, Dennis G, Welsh GI, Williams M, Saleem MA.

J Med Genet. 2017 Dec;54(12):795-804. doi: 10.1136/jmedgenet-2017-104811. Epub 2017 Aug 5.

6.

Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis.

Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, Hames TJ, Scotton CJ, Welsh GI, Bates DO, Millar AB.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):479-493. doi: 10.1164/rccm.201603-0568OC.

7.

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells.

Ourradi K, Blythe T, Jarrett C, Barratt SL, Welsh GI, Millar AB.

Respir Res. 2017 Jun 2;18(1):116. doi: 10.1186/s12931-017-0602-1.

8.

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

Bierzynska A, McCarthy HJ, Soderquest K, Sen ES, Colby E, Ding WY, Nabhan MM, Kerecuk L, Hegde S, Hughes D, Marks S, Feather S, Jones C, Webb NJ, Ognjanovic M, Christian M, Gilbert RD, Sinha MD, Lord GM, Simpson M, Koziell AB, Welsh GI, Saleem MA.

Kidney Int. 2017 Apr;91(4):937-947. doi: 10.1016/j.kint.2016.10.013. Epub 2017 Jan 20.

PMID:
28117080
9.

MAGI2 Mutations Cause Congenital Nephrotic Syndrome.

Bierzynska A, Soderquest K, Dean P, Colby E, Rollason R, Jones C, Inward CD, McCarthy HJ, Simpson MA, Lord GM, Williams M, Welsh GI, Koziell AB, Saleem MA; NephroS; UK study of Nephrotic Syndrome.

J Am Soc Nephrol. 2017 May;28(5):1614-1621. doi: 10.1681/ASN.2016040387. Epub 2016 Dec 8.

10.

VEGF regulates local inhibitory complement proteins in the eye and kidney.

Keir LS, Firth R, Aponik L, Feitelberg D, Sakimoto S, Aguilar E, Welsh GI, Richards A, Usui Y, Satchell SC, Kuzmuk V, Coward RJ, Goult J, Bull KR, Sharma R, Bharti K, Westenskow PD, Michael IP, Saleem MA, Friedlander M.

J Clin Invest. 2017 Jan 3;127(1):199-214. doi: 10.1172/JCI86418. Epub 2016 Dec 5.

11.

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways.

Jiang L, Hindmarch CC, Rogers M, Campbell C, Waterfall C, Coghill J, Mathieson PW, Welsh GI.

Sci Rep. 2016 Oct 24;6:35671. doi: 10.1038/srep35671.

12.

Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement.

Rigothier C, Saleem MA, Bourget C, Mathieson PW, Combe C, Welsh GI.

Cell Signal. 2016 Oct;28(10):1470-8. doi: 10.1016/j.cellsig.2016.06.017. Epub 2016 Jul 1.

PMID:
27377965
13.

Kinetic regulation of multi-ligand binding proteins.

Salakhieva DV, Sadreev II, Chen MZ, Umezawa Y, Evstifeev AI, Welsh GI, Kotov NV.

BMC Syst Biol. 2016 Apr 18;10:32. doi: 10.1186/s12918-016-0277-0.

14.

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.

Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI.

Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252.

15.

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus.

Kumar PA, Welsh GI, Raghu G, Menon RK, Saleem MA, Reddy GB.

Arch Biochem Biophys. 2016 Jan 15;590:10-19. doi: 10.1016/j.abb.2015.11.003. Epub 2015 Nov 10.

PMID:
26550927
16.

Editorial: Podocyte Pathology and Nephropathy.

Lewko B, Welsh GI, Jankowski M.

Front Endocrinol (Lausanne). 2015 Sep 17;6:145. doi: 10.3389/fendo.2015.00145. eCollection 2015. No abstract available.

17.

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.

Santamaria B, Marquez E, Lay A, Carew RM, González-Rodríguez Á, Welsh GI, Ni L, Hale LJ, Ortiz A, Saleem MA, Brazil DP, Coward RJ, Valverde ÁM.

Biochim Biophys Acta. 2015 Dec;1853(12):3224-34. doi: 10.1016/j.bbamcr.2015.09.020. Epub 2015 Sep 16. Erratum in: Biochim Biophys Acta. 2016 Apr;1863(4):786.

18.

Clinical and genetic analysis of patients with cystinuria in the United Kingdom.

Rhodes HL, Yarram-Smith L, Rice SJ, Tabaksert A, Edwards N, Hartley A, Woodward MN, Smithson SL, Tomson C, Welsh GI, Williams M, Thwaites DT, Sayer JA, Coward RJ.

Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1235-45. doi: 10.2215/CJN.10981114. Epub 2015 May 11.

19.

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.

Lennon R, Stuart HM, Bierzynska A, Randles MJ, Kerr B, Hillman KA, Batra G, Campbell J, Storey H, Flinter FA, Koziell A, Welsh GI, Saleem MA, Webb NJ, Woolf AS.

Pediatr Nephrol. 2015 Sep;30(9):1459-65. doi: 10.1007/s00467-015-3067-9. Epub 2015 Mar 5.

20.

Generating conditionally immortalised podocyte cell lines from wild-type mice.

Keir LS, Firth R, May C, Ni L, Welsh GI, Saleem MA.

Nephron. 2015;129(2):128-36.

PMID:
25720381

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