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Items: 1 to 20 of 143

1.

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS.

Science. 2017 Jul 28;357(6349):414-417. doi: 10.1126/science.aam7787.

PMID:
28751611
2.

Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.

Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA.

Blood. 2017 Jun 1;129(22):3000-3008. doi: 10.1182/blood-2017-02-766204. Epub 2017 Apr 19.

PMID:
28424165
3.

Operon mRNAs are organized into ORF-centric structures that predict translation efficiency.

Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA.

Elife. 2017 Jan 31;6. pii: e22037. doi: 10.7554/eLife.22037.

4.

Translation from unconventional 5' start sites drives tumour initiation.

Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E.

Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11.

5.

Model-guided optogenetic study of PKA signaling in budding yeast.

Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H.

Mol Biol Cell. 2017 Jan 1;28(1):221-227. doi: 10.1091/mbc.E16-06-0354. Epub 2016 Nov 9.

6.

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS.

Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048.

PMID:
27984733
7.

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A.

Cell. 2016 Dec 15;167(7):1853-1866.e17. doi: 10.1016/j.cell.2016.11.038.

PMID:
27984732
8.

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA.

Science. 2017 Jan 6;355(6320). pii: aah7111. doi: 10.1126/science.aah7111. Epub 2016 Dec 15.

9.

The mTOR Complex Controls HIV Latency.

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E.

Cell Host Microbe. 2016 Dec 14;20(6):785-797. doi: 10.1016/j.chom.2016.11.001.

PMID:
27978436
10.

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum.

Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M.

Nature. 2016 Nov 30;540(7631):134-138. doi: 10.1038/nature20169.

11.
12.

DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman JS, Rouskin S.

Nat Methods. 2017 Jan;14(1):75-82. doi: 10.1038/nmeth.4057. Epub 2016 Nov 7.

13.

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS.

Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760.

14.

Dynamic translation regulation in Caulobacter cell cycle control.

Schrader JM, Li GW, Childers WS, Perez AM, Weissman JS, Shapiro L, McAdams HH.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6859-E6867. Epub 2016 Oct 17.

15.

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22.

16.

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA.

Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009.

17.

Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.

Liu YC, Fujimori DG, Weissman JS.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4015-24. doi: 10.1073/pnas.1608795113. Epub 2016 Jun 28.

18.

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3892-900. doi: 10.1073/pnas.1600582113. Epub 2016 Jun 20.

19.

A scalable strategy for high-throughput GFP tagging of endogenous human proteins.

Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3501-8. doi: 10.1073/pnas.1606731113. Epub 2016 Jun 6.

20.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA.

Cell. 2016 Jun 2;165(6):1493-1506. doi: 10.1016/j.cell.2016.05.003. Epub 2016 May 26.

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