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Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100.

Morrow MP, Kraynyak KA, Sylvester AJ, Shen X, Amante D, Sakata L, Parker L, Yan J, Boyer J, Roh C, Humeau L, Khan AS, Broderick K, Marcozzi-Pierce K, Giffear M, Lee J, Trimble CL, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther Oncolytics. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25.


A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.

Griffiths KL, Villarreal DO, Weiner DB, Khader SA.

Hum Vaccin Immunother. 2016 Oct 2;12(10):2649-2653. doi: 10.1080/21645515.2016.1197454.


Protocols for Developing Novel Chikungunya Virus DNA Vaccines.

Chung C, Ugen KE, Sardesai NY, Weiner DB, Muthumani K.

Methods Mol Biol. 2016;1426:311-32. doi: 10.1007/978-1-4939-3618-2_28.


Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects.

Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, Bagarazzi ML, Muthumani K, Boyer J, Agarwal V, Nicoletti F, Bart S, Kim JJ, Weiner DB, Sardesai NY.

Clin Pharmacol Drug Dev. 2016 Mar;5(2):91-101. doi: 10.1002/cpdd.193.


DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines.

Chu JS, Villarreal DO, Weiner DB.

Methods Mol Biol. 2016;1403:355-61. doi: 10.1007/978-1-4939-3387-7_18.


Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus.

Muthumani K, Block P, Flingai S, Muruganantham N, Chaaithanya IK, Tingey C, Wise M, Reuschel EL, Chung C, Muthumani A, Sarangan G, Srikanth P, Khan AS, Vijayachari P, Sardesai NY, Kim JJ, Ugen KE, Weiner DB.

J Infect Dis. 2016 Aug 1;214(3):369-78. doi: 10.1093/infdis/jiw111.


Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.

Trimble CL, Morrow MP, Kraynyak KA, Shen X, Dallas M, Yan J, Edwards L, Parker RL, Denny L, Giffear M, Brown AS, Marcozzi-Pierce K, Shah D, Slager AM, Sylvester AJ, Khan A, Broderick KE, Juba RJ, Herring TA, Boyer J, Lee J, Sardesai NY, Weiner DB, Bagarazzi ML.

Lancet. 2015 Nov 21;386(10008):2078-88. doi: 10.1016/S0140-6736(15)00239-1.


REDD1 Is Essential for Optimal T Cell Proliferation and Survival.

Reuschel EL, Wang J, Shivers DK, Muthumani K, Weiner DB, Ma Z, Finkel TH.

PLoS One. 2015 Aug 24;10(8):e0136323. doi: 10.1371/journal.pone.0136323.


A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates.

Muthumani K, Falzarano D, Reuschel EL, Tingey C, Flingai S, Villarreal DO, Wise M, Patel A, Izmirly A, Aljuaid A, Seliga AM, Soule G, Morrow M, Kraynyak KA, Khan AS, Scott DP, Feldmann F, LaCasse R, Meade-White K, Okumura A, Ugen KE, Sardesai NY, Kim JJ, Kobinger G, Feldmann H, Weiner DB.

Sci Transl Med. 2015 Aug 19;7(301):301ra132. doi: 10.1126/scitranslmed.aac7462.


Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy.

Flingai S, Plummer EM, Patel A, Shresta S, Mendoza JM, Broderick KE, Sardesai NY, Muthumani K, Weiner DB.

Sci Rep. 2015 Jul 29;5:12616. doi: 10.1038/srep12616.


DNA vaccines 2014 meeting: Highlights and overview.

Ugen KE, Weiner DB.

Hum Vaccin Immunother. 2015;11(8):1887-8. doi: 10.1080/21645515.2015.1066947. No abstract available.


DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge.

Scott VL, Villarreal DO, Hutnick NA, Walters JN, Ragwan E, Bdeir K, Yan J, Sardesai NY, Finnefrock AC, Casimiro DR, Weiner DB.

Hum Vaccin Immunother. 2015;11(8):1961-71. doi: 10.1080/21645515.2015.1066051.


Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.

Villarreal DO, Wise MC, Siefert RJ, Yan J, Wood LM, Weiner DB.

Mol Ther. 2015 Oct;23(10):1653-62. doi: 10.1038/mt.2015.120.


Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice.

Scott VL, Patel A, Villarreal DO, Hensley SE, Ragwan E, Yan J, Sardesai NY, Rothwell PJ, Extance JP, Caproni LJ, Weiner DB.

Hum Vaccin Immunother. 2015;11(8):1972-82. doi: 10.1080/21645515.2015.1022008.


Alarmin IL-33 elicits potent TB-specific cell-mediated responses.

Villarreal DO, Siefert RJ, Weiner DB.

Hum Vaccin Immunother. 2015;11(8):1954-60. doi: 10.1080/21645515.2015.1026499.


An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates.

Wise MC, Hutnick NA, Pollara J, Myles DJ, Williams C, Yan J, LaBranche CC, Khan AS, Sardesai NY, Montefiori D, Barnett SW, Zolla-Pazner S, Ferrari G, Weiner DB.

J Virol. 2015 Sep;89(18):9154-66. doi: 10.1128/JVI.00652-15.


Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45.

Vijayachari P, Vedhagiri K, Mallilankaraman K, Mathur PP, Sardesai NY, Weiner DB, Ugen KE, Muthumani K.

Hum Vaccin Immunother. 2015;11(8):1945-53. doi: 10.1080/21645515.2015.1047117.


Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.

Kutzler MA, Wise MC, Hutnick NA, Moldoveanu Z, Hunter M, Reuter MA, Yuan S, Yan J, Ginsberg AA, Sylvester A, Pahar B, Carnathan DG, Kathuria N, Khan AS, Montefiori D, Sardesai NY, Betts MR, Mestecky J, Marx PA, Weiner DB.

Mucosal Immunol. 2016 Jan;9(1):13-23. doi: 10.1038/mi.2015.31.


Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.

Villarreal DO, Svoronos N, Wise MC, Shedlock DJ, Morrow MP, Conejo-Garcia JR, Weiner DB.

Vaccine. 2015 Aug 20;33(35):4313-20. doi: 10.1016/j.vaccine.2015.03.086.


Synthetic DNA approach to cytomegalovirus vaccine/immune therapy.

Wu SJ, Villarreal DO, Shedlock DJ, Weiner DB.

Adv Exp Med Biol. 2015;848:131-48. doi: 10.1007/978-1-4939-2432-5_7. Review.

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