Format

Send to

Choose Destination
  • Unmatched double quote ignored.
Soc Sci Med. 2018 Apr;203:35-42. doi: 10.1016/j.socscimed.2018.03.008. Epub 2018 Mar 5.

"We are the heroes because we are ready to die for this country": Participants' decision-making and grounded ethics in an Ebola vaccine clinical trial.

Author information

1
College of Medicine and Allied Health Sciences (COMAHS), University of Sierra Leone, Fourah Bay College Campus, Freetown, Sierra Leone.
2
University of Bath, Claverton Down Road, Bath, BA2 7AY, United Kingdom. Electronic address: l.enria@bath.ac.uk.
3
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
4
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.

Abstract

The 2014-2016 Ebola epidemic presented a challenging setting in which to carry out clinical trials. This paper reports findings from social science research carried out in Kambia, Northern Sierra Leone during first year of an Ebola vaccine trial (August 2015-July 2016). The social science team collected data through ethnographic observation, 42 in depth interviews; 4 life narratives; 200 exit interviews; 31 key informant interviews; and 8 focus group discussions with trial participants and community members not enrolled in the trial. Whilst research often focuses on why people refuse vaccination, we instead explore participant motivations for volunteering for the study, in spite of prevailing anxieties, rumours and mistrust during and after the Ebola outbreak. In so doing the paper contributes to on-going debates about research ethics and community engagement in resource poor contexts, offering reflections from an emergency and post-epidemic setting. We analyse participants' perceptions of the risks and benefits of participations, highlighting the importance of a contextual approach. We focus on four types of motivation: altruism; curiosity and hope; health-seeking; and notions of exchange, and argue for the role of social science in developing grounded research ethics and community engagement strategies that can take into account context and local realities.

KEYWORDS:

Clinical trials; Ebola; Research ethics; Sierra Leone; Vaccine

PMID:
29544144
DOI:
10.1016/j.socscimed.2018.03.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center