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Items: 1 to 20 of 152


A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.

Wojtaszek JL, Chatterjee N, Najeeb J, Ramos A, Lee M, Bian K, Xue JY, Fenton BA, Park H, Li D, Hemann MT, Hong J, Walker GC, Zhou P.

Cell. 2019 Jun 4. pii: S0092-8674(19)30556-2. doi: 10.1016/j.cell.2019.05.028. [Epub ahead of print]


A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action.

Yang JH, Wright SN, Hamblin M, McCloskey D, Alcantar MA, Schrübbers L, Lopatkin AJ, Satish S, Nili A, Palsson BO, Walker GC, Collins JJ.

Cell. 2019 May 30;177(6):1649-1661.e9. doi: 10.1016/j.cell.2019.04.016. Epub 2019 May 9.


Brain Injury and Impact Characteristics.

Saboori P, Walker G.

Ann Biomed Eng. 2019 Jan 23. doi: 10.1007/s10439-019-02199-z. [Epub ahead of print]


Cacluated Decisions: TASH (Trauma Associated Severe Hemorrhage) Score

Walker G, Kwon R.

Emerg Med Pract. 2018 Sep 1;16(3 Suppl):1-2.


Incomplete base excision repair contributes to cell death from antibiotics and other stresses.

Gruber CC, Walker GC.

DNA Repair (Amst). 2018 Nov;71:108-117. doi: 10.1016/j.dnarep.2018.08.014. Epub 2018 Aug 25. Review.


Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex.

Rizzo AA, Vassel FM, Chatterjee N, D'Souza S, Li Y, Hao B, Hemann MT, Walker GC, Korzhnev DM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8191-E8200. doi: 10.1073/pnas.1801149115. Epub 2018 Aug 15.


Elevated Levels of Era GTPase Improve Growth, 16S rRNA Processing, and 70S Ribosome Assembly of Escherichia coli Lacking Highly Conserved Multifunctional YbeY Endoribonuclease.

Ghosal A, Babu VMP, Walker GC.

J Bacteriol. 2018 Aug 10;200(17). pii: e00278-18. doi: 10.1128/JB.00278-18. Print 2018 Sep 1.


Robustness encoded across essential and accessory replicons of the ecologically versatile bacterium Sinorhizobium meliloti.

diCenzo GC, Benedict AB, Fondi M, Walker GC, Finan TM, Mengoni A, Griffitts JS.

PLoS Genet. 2018 Apr 19;14(4):e1007357. doi: 10.1371/journal.pgen.1007357. eCollection 2018 Apr.


Important Late-Stage Symbiotic Role of the Sinorhizobium meliloti Exopolysaccharide Succinoglycan.

Arnold MFF, Penterman J, Shabab M, Chen EJ, Walker GC.

J Bacteriol. 2018 Jun 11;200(13). pii: e00665-17. doi: 10.1128/JB.00665-17. Print 2018 Jul 1.


Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus.

Budnick JA, Sheehan LM, Colquhoun JM, Dunman PM, Walker GC, Roop RM 2nd, Caswell CC.

J Bacteriol. 2018 May 24;200(12). pii: e00105-18. doi: 10.1128/JB.00105-18. Print 2018 Jun 15.


Calculated decisions: Centor Score (Modified/McIsaac) for strep pharyngitis

Walker G, Kwon R.

Pediatr Emerg Med Pract. 2017 Dec 1;14(Suppl 12):1-3. No abstract available.


Calculated decisions: Emergency Department Assessment of Chest Pain Score (EDACS)

Walker G, Habboushe J.

Emerg Med Pract. 2017 Oct 9;19(Suppl 7):1-2. No abstract available.


Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Yamanaka K, Chatterjee N, Hemann MT, Walker GC.

PLoS Genet. 2017 Aug 17;13(8):e1006842. doi: 10.1371/journal.pgen.1006842. eCollection 2017 Aug. Review. No abstract available.


Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.

Takahashi N, Gruber CC, Yang JH, Liu X, Braff D, Yashaswini CN, Bhubhanil S, Furuta Y, Andreescu S, Collins JJ, Walker GC.

Proc Natl Acad Sci U S A. 2017 Aug 9. pii: 201707466. doi: 10.1073/pnas.1707466114. [Epub ahead of print]


Genome-Wide Sensitivity Analysis of the Microsymbiont Sinorhizobium meliloti to Symbiotically Important, Defensin-Like Host Peptides.

Arnold MFF, Shabab M, Penterman J, Boehme KL, Griffitts JS, Walker GC.

MBio. 2017 Aug 1;8(4). pii: e01060-17. doi: 10.1128/mBio.01060-17.


Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

Sail V, Rizzo AA, Chatterjee N, Dash RC, Ozen Z, Walker GC, Korzhnev DM, Hadden MK.

ACS Chem Biol. 2017 Jul 21;12(7):1903-1912. doi: 10.1021/acschembio.6b01144. Epub 2017 Jun 9.


Mechanisms of DNA damage, repair, and mutagenesis.

Chatterjee N, Walker GC.

Environ Mol Mutagen. 2017 Jun;58(5):235-263. doi: 10.1002/em.22087. Epub 2017 May 9. Review.


A before-after study of multidisciplinary Out-of-Hours handover: combining management and frontline efforts to create sustainable improvement.

Pennell C, Flynn L, Boulton B, Hughes T, Walker G, McCulloch P.

Int J Qual Health Care. 2017 Apr 1;29(2):228-233. doi: 10.1093/intqhc/mzx002.


C21orf57 is a human homologue of bacterial YbeY proteins.

Ghosal A, Köhrer C, Babu VMP, Yamanaka K, Davies BW, Jacob AI, Ferullo DJ, Gruber CC, Vercruysse M, Walker GC.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):612-617. doi: 10.1016/j.bbrc.2017.01.149. Epub 2017 Jan 30.


Identification of YbeY-Protein Interactions Involved in 16S rRNA Maturation and Stress Regulation in Escherichia coli.

Vercruysse M, Köhrer C, Shen Y, Proulx S, Ghosal A, Davies BW, RajBhandary UL, Walker GC.

MBio. 2016 Nov 8;7(6). pii: e01785-16. doi: 10.1128/mBio.01785-16.

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