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Items: 1 to 20 of 144

1.

Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.

Cao P, Aoki Y, Badri L, Walker NM, Manning CM, Lagstein A, Fearon ER, Lama VN.

J Clin Invest. 2017 Apr 3;127(4):1517-1530. doi: 10.1172/JCI88896. Epub 2017 Feb 27.

2.

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

Todd JA, Evangelou M, Cutler AJ, Pekalski ML, Walker NM, Stevens HE, Porter L, Smyth DJ, Rainbow DB, Ferreira RC, Esposito L, Hunter KM, Loudon K, Irons K, Yang JH, Bell CJ, Schuilenburg H, Heywood J, Challis B, Neupane S, Clarke P, Coleman G, Dawson S, Goymer D, Anselmiova K, Kennet J, Brown J, Caddy SL, Lu J, Greatorex J, Goodfellow I, Wallace C, Tree TI, Evans M, Mander AP, Bond S, Wicker LS, Waldron-Lynch F.

PLoS Med. 2016 Oct 11;13(10):e1002139. doi: 10.1371/journal.pmed.1002139. eCollection 2016 Oct.

3.

Reply: Epithelial alkalinity and hyperproliferation in the Cftr KO intestine.

Walker NM, Liu J, Stein SR, Strubberg AM, Clarke LL.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1184. doi: 10.1152/ajpgi.00161.2016. No abstract available.

4.

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.

Bodea CA, Neale BM, Ripke S; International IBD Genetics Consortium, Daly MJ, Devlin B, Roeder K.

Am J Hum Genet. 2016 May 5;98(5):857-68. doi: 10.1016/j.ajhg.2016.02.025. Epub 2016 Apr 14.

5.

Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.

Walker NM, Belloli EA, Stuckey L, Chan KM, Lin J, Lynch W, Chang A, Mazzoni SM, Fingar DC, Lama VN.

J Biol Chem. 2016 Mar 18;291(12):6262-71. doi: 10.1074/jbc.M115.672170. Epub 2016 Jan 11.

6.

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.

Truman LA, Pekalski ML, Kareclas P, Evangelou M, Walker NM, Howlett J, Mander AP, Kennet J, Wicker LS, Bond S, Todd JA, Waldron-Lynch F.

BMJ Open. 2015 Dec 8;5(12):e009799. doi: 10.1136/bmjopen-2015-009799.

7.

Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.

Walker NM, Liu J, Stein SR, Stefanski CD, Strubberg AM, Clarke LL.

Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G70-80. doi: 10.1152/ajpgi.00236.2015. Epub 2015 Nov 5.

8.

Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Fortune MD, Guo H, Burren O, Schofield E, Walker NM, Ban M, Sawcer SJ, Bowes J, Worthington J, Barton A, Eyre S, Todd JA, Wallace C.

Nat Genet. 2015 Aug;47(8):962. doi: 10.1038/ng0815-962c. No abstract available.

PMID:
26220137
9.

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

Wallace C, Cutler AJ, Pontikos N, Pekalski ML, Burren OS, Cooper JD, García AR, Ferreira RC, Guo H, Walker NM, Smyth DJ, Rich SS, Onengut-Gumuscu S, Sawcer SJ, Ban M, Richardson S, Todd JA, Wicker LS.

PLoS Genet. 2015 Jun 24;11(6):e1005272. doi: 10.1371/journal.pgen.1005272. eCollection 2015 Jun.

10.

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Fortune MD, Guo H, Burren O, Schofield E, Walker NM, Ban M, Sawcer SJ, Bowes J, Worthington J, Barton A, Eyre S, Todd JA, Wallace C.

Nat Genet. 2015 Jul;47(7):839-46. doi: 10.1038/ng.3330. Epub 2015 Jun 8. Erratum in: Nat Genet. 2015 Aug;47(8):962.

11.

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

Heywood J, Evangelou M, Goymer D, Kennet J, Anselmiova K, Guy C, O'Brien C, Nutland S, Brown J, Walker NM, Todd JA, Waldron-Lynch F.

Trials. 2015 Mar 11;16:86. doi: 10.1186/s13063-015-0583-7.

12.

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P; Type 1 Diabetes Genetics Consortium, Todd JA, Wallace C, Concannon P, Rich SS.

Nat Genet. 2015 Apr;47(4):381-6. doi: 10.1038/ng.3245. Epub 2015 Mar 9.

13.

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.

Ferreira RC, Simons HZ, Thompson WS, Cutler AJ, Dopico XC, Smyth DJ, Mashar M, Schuilenburg H, Walker NM, Dunger DB, Wallace C, Todd JA, Wicker LS, Pekalski ML.

Diabetologia. 2015 Apr;58(4):781-90. doi: 10.1007/s00125-015-3509-8. Epub 2015 Feb 6.

14.

Defective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease.

Liu J, Walker NM, Ootani A, Strubberg AM, Clarke LL.

J Clin Invest. 2015 Mar 2;125(3):1056-68. doi: 10.1172/JCI73193. Epub 2015 Feb 2.

15.

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes.

Cooper NJ, Shtir CJ, Smyth DJ, Guo H, Swafford AD, Zanda M, Hurles ME, Walker NM, Plagnol V, Cooper JD, Howson JM, Burren OS, Onengut-Gumuscu S, Rich SS, Todd JA.

Hum Mol Genet. 2015 Mar 15;24(6):1774-90. doi: 10.1093/hmg/ddu581. Epub 2014 Nov 25.

16.

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.

Evangelou M, Smyth DJ, Fortune MD, Burren OS, Walker NM, Guo H, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Todd JA, Wallace C.

Genet Epidemiol. 2014 Dec;38(8):661-70. doi: 10.1002/gepi.21853. Epub 2014 Nov 4.

17.

Returning findings within longitudinal cohort studies: the 1958 birth cohort as an exemplar.

Wallace SE, Walker NM, Elliott J.

Emerg Themes Epidemiol. 2014 Aug 4;11:10. doi: 10.1186/1742-7622-11-10. eCollection 2014.

18.

UK combat-related pelvic junctional vascular injuries 2008-2011: implications for future intervention.

Walker NM, Eardley W, Clasper JC.

Injury. 2014 Oct;45(10):1585-9. doi: 10.1016/j.injury.2014.07.004. Epub 2014 Jul 16.

PMID:
25092203
19.

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.

Waldron-Lynch F, Kareclas P, Irons K, Walker NM, Mander A, Wicker LS, Todd JA, Bond S.

BMJ Open. 2014 Jun 4;4(6):e005559. doi: 10.1136/bmjopen-2014-005559.

20.

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data.

Chen GB, Lee SH, Brion MJ, Montgomery GW, Wray NR, Radford-Smith GL, Visscher PM; International IBD Genetics Consortium.

Hum Mol Genet. 2014 Sep 1;23(17):4710-20. doi: 10.1093/hmg/ddu174. Epub 2014 Apr 11.

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