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Items: 1 to 20 of 28


Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells.

Coursey TG, Bian F, Zaheer M, Pflugfelder SC, Volpe EA, de Paiva CS.

Mucosal Immunol. 2016 Oct 5. doi: 10.1038/mi.2016.83. [Epub ahead of print]


Interferon-gamma deficiency protects against aging-related goblet cell loss.

Volpe EA, Henriksson JT, Wang C, Barbosa FL, Zaheer M, Zhang X, Pflugfelder SC, de Paiva CS.

Oncotarget. 2016 Sep 6. doi: 10.18632/oncotarget.11872. [Epub ahead of print]


Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye.

Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS.

Ocul Surf. 2016 Apr;14(2):242-54. doi: 10.1016/j.jtos.2015.11.006.


Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss.

Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7545-50. doi: 10.1167/iovs.15-17627.


Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas.

Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4908-18. doi: 10.1167/iovs.15-16631.


Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome.

Bian F, Barbosa FL, Corrales RM, Pelegrino FS, Volpe EA, Pflugfelder SC, de Paiva CS.

Arthritis Res Ther. 2015 Mar 10;17:53. doi: 10.1186/s13075-015-0582-9.


Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction.

You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2224-33. doi: 10.1167/iovs.14-15668.


Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.

McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS.

Am J Pathol. 2014 Mar;184(3):631-43. doi: 10.1016/j.ajpath.2013.11.019.


Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye.

Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC.

Exp Eye Res. 2014 Jan;118:117-24. doi: 10.1016/j.exer.2013.11.011.


Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease.

Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS.

PLoS One. 2013 Nov 4;8(11):e78508. doi: 10.1371/journal.pone.0078508.


CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome.

Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS.

Mucosal Immunol. 2014 Mar;7(2):417-27. doi: 10.1038/mi.2013.61.


Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.

Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS.

J Leukoc Biol. 2013 Dec;94(6):1293-301. doi: 10.1189/jlb.1012524.


Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice.

Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS.

Arthritis Res Ther. 2012 Nov 1;14(6):R234. doi: 10.1186/ar4077.


NK cells promote Th-17 mediated corneal barrier disruption in dry eye.

Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS.

PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822.


Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.

De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD 3rd, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC.

PLoS One. 2011;6(12):e29017. doi: 10.1371/journal.pone.0029017.


Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ.

Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC.

Am J Pathol. 2011 Oct;179(4):1807-14. doi: 10.1016/j.ajpath.2011.06.030.


Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.

Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC.

Invest Ophthalmol Vis Sci. 2011 Aug 9;52(9):6279-85. doi: 10.1167/iovs.10-7081.


Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13.

De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC.

Mucosal Immunol. 2011 Jul;4(4):397-408. doi: 10.1038/mi.2010.82.


Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.

Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe EA, Kim SS, Katuri V, Kallakury B, Pishvaian M, Albanese C, Mendelson J, Zasloff M, Rashid A, Fishbein T, Evans SR, Sidawy A, Reddy EP, Mishra B, Johnson LB, Shetty K, Mishra L.

Oncogene. 2007 Nov 1;26(50):7103-10.


Inactivation of TGF-beta signaling in lung cancer results in increased CDK4 activity that can be rescued by ELF.

Baek HJ, Kim SS, da Silva FM, Volpe EA, Evans S, Mishra B, Mishra L, Marshall MB.

Biochem Biophys Res Commun. 2006 Aug 11;346(4):1150-7.

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