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Apolipoprotein E-Mimetic Peptide COG1410 Promotes Autophagy by Phosphorylating GSK-3β in Early Brain Injury Following Experimental Subarachnoid Hemorrhage.

Li X, Peng J, Pang J, Wu Y, Huang X, Li Y, Zhou J, Gu L, Sun X, Chen L, Vitek MP, Jiang Y.

Front Neurosci. 2018 Mar 5;12:127. doi: 10.3389/fnins.2018.00127. eCollection 2018.


Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.

Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K.

Mol Cancer Res. 2018 Mar;16(3):554-563. doi: 10.1158/1541-7786.MCR-17-0393. Epub 2018 Jan 12.


OP449 inhibits breast cancer growth without adverse metabolic effects.

Shlomai G, Zelenko Z, Antoniou IM, Stasinopoulos M, Tobin-Hess A, Vitek MP, LeRoith D, Gallagher EJ.

Endocr Relat Cancer. 2017 Oct;24(10):519-529. doi: 10.1530/ERC-17-0077.


Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.

Pang J, Chen Y, Kuai L, Yang P, Peng J, Wu Y, Chen Y, Vitek MP, Chen L, Sun X, Jiang Y.

Transl Stroke Res. 2017 Jun;8(3):257-272. doi: 10.1007/s12975-016-0507-1. Epub 2016 Oct 31.


Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.

Richard NP, Pippa R, Cleary MM, Puri A, Tibbitts D, Mahmood S, Christensen DJ, Jeng S, McWeeney S, Look AT, Chang BH, Tyner JW, Vitek MP, Odero MD, Sears R, Agarwal A.

Oncotarget. 2016 Dec 20;7(51):84214-84227. doi: 10.18632/oncotarget.12394.


Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR.

Ann Rheum Dis. 2017 Mar;76(3):612-619. doi: 10.1136/annrheumdis-2016-209424. Epub 2016 Sep 5.


Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.

Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, Cao F, Sun X, Chen L, Vitek MP, Jiang Y.

Oncotarget. 2016 Aug 30;7(35):56030-56044. doi: 10.18632/oncotarget.10821.


Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study.

Qin X, You H, Cao F, Wu Y, Peng J, Pang J, Xu H, Chen Y, Chen L, Vitek MP, Li F, Sun X, Jiang Y.

J Neurotrauma. 2017 Feb 15;34(4):943-951. doi: 10.1089/neu.2016.4485. Epub 2016 Sep 27.


An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.

Wu Y, Pang J, Peng J, Cao F, Vitek MP, Li F, Jiang Y, Sun X.

Neurosci Lett. 2016 Aug 3;627:92-9. doi: 10.1016/j.neulet.2016.05.058. Epub 2016 May 27.


Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.

Hu X, Garcia C, Fazli L, Gleave M, Vitek MP, Jansen M, Christensen D, Mulholland DJ.

Sci Rep. 2015 Nov 13;5:15182. doi: 10.1038/srep15182.


Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.

Cao F, Jiang Y, Wu Y, Zhong J, Liu J, Qin X, Chen L, Vitek MP, Li F, Xu L, Sun X.

J Neurotrauma. 2016 Jan 15;33(2):175-82. doi: 10.1089/neu.2015.3887. Epub 2015 Jul 20.


The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma.

Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K.

J Vet Med Sci. 2015 Nov;77(11):1451-6. doi: 10.1292/jvms.15-0193. Epub 2015 Jun 11.


Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.

Kan MJ, Lee JE, Wilson JG, Everhart AL, Brown CM, Hoofnagle AN, Jansen M, Vitek MP, Gunn MD, Colton CA.

J Neurosci. 2015 Apr 15;35(15):5969-82. doi: 10.1523/JNEUROSCI.4668-14.2015.


The N-terminal Set-β Protein Isoform Induces Neuronal Death.

Trakhtenberg EF, Morkin MI, Patel KH, Fernandez SG, Sang A, Shaw P, Liu X, Wang Y, Mlacker GM, Gao H, Velmeshev D, Dombrowski SM, Vitek MP, Goldberg JL.

J Biol Chem. 2015 May 22;290(21):13417-26. doi: 10.1074/jbc.M114.633883. Epub 2015 Apr 1.


The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.

Hoos MD, Vitek MP, Ridnour LA, Wilson J, Jansen M, Everhart A, Wink DA, Colton CA.

Mol Neurodegener. 2014 Nov 17;9:50. doi: 10.1186/1750-1326-9-50.


mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

Colton CA, Wilson JG, Everhart A, Wilcock DM, Puoliväli J, Heikkinen T, Oksman J, Jääskeläinen O, Lehtimäki K, Laitinen T, Vartiainen N, Vitek MP.

J Neuropathol Exp Neurol. 2014 Aug;73(8):752-69. doi: 10.1097/NEN.0000000000000094.


Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity.

Pippa R, Dominguez A, Christensen DJ, Moreno-Miralles I, Blanco-Prieto MJ, Vitek MP, Odero MD.

Leukemia. 2014 Sep;28(9):1915-8. doi: 10.1038/leu.2014.141. Epub 2014 Apr 30. No abstract available.


Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.

Farrell AS, Allen-Petersen B, Daniel CJ, Wang X, Wang Z, Rodriguez S, Impey S, Oddo J, Vitek MP, Lopez C, Christensen DJ, Sheppard B, Sears RC.

Mol Cancer Res. 2014 Jun;12(6):924-39. doi: 10.1158/1541-7786.MCR-13-0542. Epub 2014 Mar 25.


ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.

Wang R, Hong J, Lu M, Neil JE, Vitek MP, Liu X, Warner DS, Li F, Sheng H.

J Neurosci Res. 2014 Jul;92(7):884-92. doi: 10.1002/jnr.23371. Epub 2014 Mar 13.


Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.

Azevedo OG, Bolick DT, Roche JK, Pinkerton RF, Lima AA, Vitek MP, Warren CA, Oriá RB, Guerrant RL.

PLoS One. 2014 Feb 28;9(2):e89562. doi: 10.1371/journal.pone.0089562. eCollection 2014.

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