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Items: 1 to 20 of 27

1.

Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression.

De Gobbi M, Brazel AJ, Sharpe JA, Sloane-Stanley JA, Smith AJ, Wood WG, Vernimmen D.

Blood Cells Mol Dis. 2017 Mar 1;64:10-12. doi: 10.1016/j.bcmd.2017.02.006. [Epub ahead of print] No abstract available.

2.

Editorial preface.

Vernimmen D.

Blood Cells Mol Dis. 2017 Feb 9. pii: S1079-9796(17)30070-0. doi: 10.1016/j.bcmd.2017.02.002. [Epub ahead of print] No abstract available.

PMID:
28214138
3.

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN, Morgan M, Giles P, Sas Z, Gonzalez MV, Lawson H, Paris J, Edwards-Hicks J, Schaak K, Subramani C, Gezer D, Armesilla-Diaz A, Wills J, Easterbrook A, Coman D, So CW, O'Carroll D, Vernimmen D, Rodrigues NP, Pollard PJ, Morton NM, Finch A, Kranc KR.

J Exp Med. 2017 Mar 6;214(3):719-735. doi: 10.1084/jem.20161087. Epub 2017 Feb 15.

4.

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

Vernimmen D, Bickmore WA.

Trends Genet. 2015 Dec;31(12):696-708. doi: 10.1016/j.tig.2015.10.004. Review.

PMID:
26599498
5.

The complexity of epigenetic diseases.

Brazel AJ, Vernimmen D.

J Pathol. 2016 Jan;238(2):333-44. doi: 10.1002/path.4647. Epub 2015 Nov 17. Review.

6.

Uncovering enhancer functions using the α-globin locus.

Vernimmen D.

PLoS Genet. 2014 Oct 16;10(10):e1004668. doi: 10.1371/journal.pgen.1004668. eCollection 2014 Oct. Review.

7.

Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.

Kernohan KD, Vernimmen D, Gloor GB, Bérubé NG.

Nucleic Acids Res. 2014 Jul;42(13):8356-68. doi: 10.1093/nar/gku564. Epub 2014 Jul 2.

8.

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, Martyn GE, Artuz CM, Burdach J, Quinlan KG, Higgs DR, Whitelaw E, Pearson RC, Crossley M.

BMC Mol Biol. 2014 May 16;15:8. doi: 10.1186/1471-2199-15-8.

9.

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.

Hughes JR, Lower KM, Dunham I, Taylor S, De Gobbi M, Sloane-Stanley JA, McGowan S, Ragoussis J, Vernimmen D, Gibbons RJ, Higgs DR.

Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120361. doi: 10.1098/rstb.2012.0361. Print 2013.

10.

Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression.

Lower KM, De Gobbi M, Hughes JR, Derry CJ, Ayyub H, Sloane-Stanley JA, Vernimmen D, Garrick D, Gibbons RJ, Higgs DR.

Hum Mutat. 2013 Aug;34(8):1140-8. doi: 10.1002/humu.22343. Epub 2013 Jun 18.

PMID:
23616472
11.

Intragenic enhancers act as alternative promoters.

Kowalczyk MS, Hughes JR, Garrick D, Lynch MD, Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR.

Mol Cell. 2012 Feb 24;45(4):447-58. doi: 10.1016/j.molcel.2011.12.021. Epub 2012 Jan 19.

12.

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.

Lynch MD, Smith AJ, De Gobbi M, Flenley M, Hughes JR, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L, Meek S, Burdon T, Gibbons RJ, Garrick D, Higgs DR.

EMBO J. 2012 Jan 18;31(2):317-29. doi: 10.1038/emboj.2011.399. Epub 2011 Nov 4.

13.

Polycomb eviction as a new distant enhancer function.

Vernimmen D, Lynch MD, De Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR.

Genes Dev. 2011 Aug 1;25(15):1583-8. doi: 10.1101/gad.16985411.

14.

Generation of bivalent chromatin domains during cell fate decisions.

De Gobbi M, Garrick D, Lynch M, Vernimmen D, Hughes JR, Goardon N, Luc S, Lower KM, Sloane-Stanley JA, Pina C, Soneji S, Renella R, Enver T, Taylor S, Jacobsen SE, Vyas P, Gibbons RJ, Higgs DR.

Epigenetics Chromatin. 2011 Jun 6;4(1):9. doi: 10.1186/1756-8935-4-9.

15.

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

Lower KM, Hughes JR, De Gobbi M, Henderson S, Viprakasit V, Fisher C, Goriely A, Ayyub H, Sloane-Stanley J, Vernimmen D, Langford C, Garrick D, Gibbons RJ, Higgs DR.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21771-6. doi: 10.1073/pnas.0909331106. Epub 2009 Dec 3.

16.

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).

Vernimmen D, Marques-Kranc F, Sharpe JA, Sloane-Stanley JA, Wood WG, Wallace HA, Smith AJ, Higgs DR.

Blood. 2009 Nov 5;114(19):4253-60. doi: 10.1182/blood-2009-03-213439. Epub 2009 Aug 20.

17.

Long-range regulation of alpha-globin gene expression.

Higgs DR, Vernimmen D, Wood B.

Adv Genet. 2008;61:143-73. doi: 10.1016/S0065-2660(07)00005-3. Review.

PMID:
18282505
18.

Using genomics to study how chromatin influences gene expression.

Higgs DR, Vernimmen D, Hughes J, Gibbons R.

Annu Rev Genomics Hum Genet. 2007;8:299-325. Review.

PMID:
17506662
19.

Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.

Vernimmen D, De Gobbi M, Sloane-Stanley JA, Wood WG, Higgs DR.

EMBO J. 2007 Apr 18;26(8):2041-51. Epub 2007 Mar 22.

20.

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

De Gobbi M, Viprakasit V, Hughes JR, Fisher C, Buckle VJ, Ayyub H, Gibbons RJ, Vernimmen D, Yoshinaga Y, de Jong P, Cheng JF, Rubin EM, Wood WG, Bowden D, Higgs DR.

Science. 2006 May 26;312(5777):1215-7.

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