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Items: 1 to 20 of 122

1.

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.

Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ.

J Gastrointest Oncol. 2016 Dec;7(6):819-827. doi: 10.21037/jgo.2016.11.11. No abstract available.

2.

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG.

Nat Med. 2016 Dec 26. doi: 10.1038/nm.4256. [Epub ahead of print]

PMID:
28024083
3.

PKM2, cancer metabolism, and the road ahead.

Dayton TL, Jacks T, Vander Heiden MG.

EMBO Rep. 2016 Dec;17(12):1721-1730. Review.

PMID:
27856534
4.

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.

Nat Commun. 2016 Nov 2;7:13467. doi: 10.1038/ncomms13467. No abstract available.

5.

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.

Sullivan LB, Gui DY, Vander Heiden MG.

Nat Rev Cancer. 2016 Nov;16(11):680-693. doi: 10.1038/nrc.2016.85.

PMID:
27658530
6.

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG.

Cell Metab. 2016 Nov 8;24(5):716-727. doi: 10.1016/j.cmet.2016.09.006.

PMID:
27746050
7.

Critical Functions of the Lysosome in Cancer Biology.

Davidson SM, Vander Heiden MG.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:481-507. doi: 10.1146/annurev-pharmtox-010715-103101.

PMID:
27732799
8.

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.

PMID:
27609895
9.

Metabolic requirements for cancer cell proliferation.

Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G.

Cancer Metab. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6.

10.

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.

Cell Metab. 2016 Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001.

PMID:
27476975
11.

The importance of serine metabolism in cancer.

Mattaini KR, Sullivan MR, Vander Heiden MG.

J Cell Biol. 2016 Aug 1;214(3):249-57. doi: 10.1083/jcb.201604085. Review.

PMID:
27458133
12.

InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function.

Lewis CA, Vander Heiden MG.

Immunity. 2016 Jun 21;44(6):1243-5. doi: 10.1016/j.immuni.2016.06.004.

PMID:
27332725
13.

Targeting MTHFD2 in acute myeloid leukemia.

Pikman Y, Puissant A, Alexe G, Furman A, Chen LM, Frumm SM, Ross L, Fenouille N, Bassil CF, Lewis CA, Ramos A, Gould J, Stone RM, DeAngelo DJ, Galinsky I, Clish CB, Kung AL, Hemann MT, Vander Heiden MG, Banerji V, Stegmaier K.

J Exp Med. 2016 Jun 27;213(7):1285-306. doi: 10.1084/jem.20151574.

14.

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence.

Kelly RS, Vander Heiden MG, Giovannucci E, Mucci LA.

Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):887-906. doi: 10.1158/1055-9965.EPI-15-1223. Review.

PMID:
27197278
15.

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG.

Genes Dev. 2016 May 1;30(9):1020-33. doi: 10.1101/gad.278549.116.

16.

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070.

17.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Apr 7;165(2):497. doi: 10.1016/j.cell.2016.03.037. No abstract available.

PMID:
27058668
18.

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG.

Dev Cell. 2016 Mar 7;36(5):540-9. doi: 10.1016/j.devcel.2016.02.012.

PMID:
26954548
19.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Erratum in: Cell. 2016 Apr 7;165(2):497.

PMID:
26919427
20.

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR.

J Cell Biol. 2016 Feb 15;212(4):439-47. doi: 10.1083/jcb.201506118.

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