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Items: 1 to 20 of 172


Antiparasitic and disease-modifying activity of Nyctanthes arbor-tristis Linn. in malaria: An exploratory clinical study.

Godse CS, Tathed PS, Talwalkar SS, Vaidya RA, Amonkar AJ, Vaidya AB, Vaidya AD.

J Ayurveda Integr Med. 2016 Nov 30. pii: S0975-9476(16)30033-X. doi: 10.1016/j.jaim.2016.08.003. [Epub ahead of print]


Caged Garcinia xanthones: a novel chemical scaffold with potent antimalarial activity.

Ke H, Morrisey JM, Qu S, Chantarasriwong O, Mather MW, Theodorakis EA, Vaidya AB.

Antimicrob Agents Chemother. 2016 Oct 31. pii: AAC.01220-16. [Epub ahead of print]


Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.

Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4853-9. doi: 10.1128/AAC.00791-16.


Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum.

Das S, Bhatanagar S, Morrisey JM, Daly TM, Burns JM Jr, Coppens I, Vaidya AB.

PLoS Pathog. 2016 May 26;12(5):e1005647. doi: 10.1371/journal.ppat.1005647.


Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p.

Jenkins BJ, Daly TM, Morrisey JM, Mather MW, Vaidya AB, Bergman LW.

PLoS One. 2016 Mar 25;11(3):e0152197. doi: 10.1371/journal.pone.0152197.


Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.

Maron MI, Magle CT, Czesny B, Turturice BA, Huang R, Zheng W, Vaidya AB, Williamson KC.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1492-9. doi: 10.1128/AAC.01928-15.


ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, Kim K, Zakharov LN, Donini C, Burrows JN, Vaidya AB, Charman SA, Riscoe MK.

Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60. doi: 10.1128/AAC.01183-15.


Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.

Am J Trop Med Hyg. 2015 Jun;92(6):1195-201. doi: 10.4269/ajtmh.14-0553.


Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.

Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB.

Cell Rep. 2015 Apr 7;11(1):164-74. doi: 10.1016/j.celrep.2015.03.011.


Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon.

Meibalan E, Comunale MA, Lopez AM, Bergman LW, Mehta A, Vaidya AB, Burns JM Jr.

Eukaryot Cell. 2015 Apr;14(4):371-84. doi: 10.1128/EC.00228-14.


Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Stickles AM, de Almeida MJ, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK.

Antimicrob Agents Chemother. 2015 Apr;59(4):1977-82. doi: 10.1128/AAC.04149-14.


Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.

Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ, Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, Stasiak M, Charman SA, Angulo-Barturen I, Ferrer S, Belén Jiménez-Díaz M, Martínez MS, Gamo FJ, Avery VM, Ruecker A, Delves M, Kirk K, Berriman M, Kortagere S, Burrows J, Fan E, Bergman LW.

Nat Commun. 2014 Nov 25;5:5521. doi: 10.1038/ncomms6521.


The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB.

J Biol Chem. 2014 Dec 12;289(50):34827-37. doi: 10.1074/jbc.M114.615831.


Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax.

Rajgor DD, Gogtay NJ, Kadam VS, Kocharekar MM, Parulekar MS, Dalvi SS, Vaidya AB, Kshirsagar NA.

Malar Res Treat. 2014;2014:347018. doi: 10.1155/2014/347018.


Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k.


The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Sheiner L, Vaidya AB, McFadden GI.

Curr Opin Microbiol. 2013 Aug;16(4):452-8. doi: 10.1016/j.mib.2013.07.003. Review.


Shirodhara: A psycho-physiological profile in healthy volunteers.

Dhuri KD, Bodhe PV, Vaidya AB.

J Ayurveda Integr Med. 2013 Jan;4(1):40-4. doi: 10.4103/0975-9476.109550.


Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2013 May 30;497(7451):652. doi: 10.1038/nature12164. No abstract available.


Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.


The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya AB, Lanzer M, Deponte M.

Antimicrob Agents Chemother. 2013 May;57(5):2114-20. doi: 10.1128/AAC.02248-12.

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