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Rev Gastroenterol Mex. 2017 Oct - Dec;82(4):357-360. doi: 10.1016/j.rgmx.2017.03.009.

Correlation between preoperative serum alpha-fetoprotein levels and survival with respect to the surgical treatment of hepatocellular carcinoma at a tertiary care hospital in Veracruz, Mexico.

[Article in English, Spanish]

Author information

1
Departamento de Trasplantes de Órganos, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México. Electronic address: gmtzmier@gmail.com.
2
Departamento de Cirugía Oncológica, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México.
3
Departamento de Investigación, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México.

Abstract

INTRODUCTION:

Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival.

AIM:

Our aim was to analyze the correlation between preoperative serum alpha-fetoprotein levels and survival, following the surgical treatment of hepatocellular carcinoma.

METHODS:

Nineteen patients were prospectively followed (07/2005-01/2016). An ROC curve was created to determine the sensitivity and specificity of alpha-fetoprotein in relation to survival (Kaplan-Meier).

RESULTS:

Of the 19 patients evaluated, 57.9% were men. The mean patient age was 68.1 ± 8.5 years and survival at 1, 3, and 5 years was 89.4, 55.9, and 55.9%. The alpha-fetoprotein cutoff point was 15.1 ng/ml (sensitivity 100%, specificity 99.23%). Preoperative alpha-fetoprotein levels below 15.1, 200, 400, and 463 ng/ml correlated with better 1 and 5-year survival rates than levels above 15.1, 200, 400, and 463 ng/ml (P<.05).

CONCLUSIONS:

Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.

KEYWORDS:

Alfafetoproteína; Alpha-fetoprotein; Hepatocarcinoma; Hepatocellular carcinoma; Liver resection; Resección hepática; Sobrevida; Survival

PMID:
28893428
DOI:
10.1016/j.rgmx.2017.03.009
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