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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.


Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.

Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U.

Mol Neurodegener. 2017 Apr 11;12(1):29. doi: 10.1186/s13024-017-0170-3.


Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.

Clague MJ, Urbé S.

FEBS J. 2017 Jun;284(12):1753-1766. doi: 10.1111/febs.14007. Epub 2017 Jan 29.


The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer.

Wymant JM, Hiscox S, Westwell AD, Urbé S, Clague MJ, Jones AT.

J Cancer. 2016 Dec 9;7(15):2388-2407. eCollection 2016.


The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

Heride C, Rigden DJ, Bertsoulaki E, Cucchi D, De Smaele E, Clague MJ, Urbé S.

J Cell Sci. 2016 Nov 1;129(21):4001-4013. Epub 2016 Sep 12.


Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6.

Perrody E, Abrami L, Feldman M, Kunz B, Urbé S, van der Goot FG.

Elife. 2016 Oct 18;5. pii: e19083. doi: 10.7554/eLife.19083.


Bimodal antagonism of PKA signalling by ARHGAP36.

Eccles RL, Czajkowski MT, Barth C, Müller PM, McShane E, Grunwald S, Beaudette P, Mecklenburg N, Volkmer R, Zühlke K, Dittmar G, Selbach M, Hammes A, Daumke O, Klussmann E, Urbé S, Rocks O.

Nat Commun. 2016 Oct 7;7:12963. doi: 10.1038/ncomms12963.


The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N.

Circ Res. 2016 Feb 5;118(3):410-9. doi: 10.1161/CIRCRESAHA.115.307298. Epub 2015 Dec 14.


Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells.

Malec V, Coulson JM, Urbé S, Clague MJ.

J Proteome Res. 2015 Dec 4;14(12):5263-72. doi: 10.1021/acs.jproteome.5b00692. Epub 2015 Nov 16.


Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.

Sacco JJ, Kenyani J, Butt Z, Carter R, Chew HY, Cheeseman LP, Darling S, Denny M, Urbé S, Clague MJ, Coulson JM.

Oncotarget. 2015 May 30;6(15):13757-71.


The demographics of the ubiquitin system.

Clague MJ, Heride C, Urbé S.

Trends Cell Biol. 2015 Jul;25(7):417-26. doi: 10.1016/j.tcb.2015.03.002. Epub 2015 Apr 21. Review.


USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death.

Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urbé S.

EMBO Rep. 2015 May;16(5):618-27. doi: 10.15252/embr.201439820. Epub 2015 Mar 4.


Plasticity of mammary cell boundaries governed by EGF and actin remodeling.

Tang WYY, Beckett AJ, Prior IA, Coulson JM, Urbé S, Clague MJ.

Cell Rep. 2014 Sep 25;8(6):1722-1730. doi: 10.1016/j.celrep.2014.08.026. Epub 2014 Sep 18.


Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.


USP8 controls the trafficking and sorting of lysosomal enzymes.

MacDonald E, Urbé S, Clague MJ.

Traffic. 2014 Aug;15(8):879-88. doi: 10.1111/tra.12180. Epub 2014 Jul 3.


Ubiquitin code assembly and disassembly.

Heride C, Urbé S, Clague MJ.

Curr Biol. 2014 Mar 17;24(6):R215-20. doi: 10.1016/j.cub.2014.02.002. Review.


The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.

Sacco JJ, Yau TY, Darling S, Patel V, Liu H, Urbé S, Clague MJ, Coulson JM.

Oncogene. 2014 Aug 14;33(33):4265-72. doi: 10.1038/onc.2013.512. Epub 2013 Dec 2.


Deubiquitylases from genes to organism.

Clague MJ, Barsukov I, Coulson JM, Liu H, Rigden DJ, Urbé S.

Physiol Rev. 2013 Jul;93(3):1289-315. doi: 10.1152/physrev.00002.2013. Review.


The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit.

Faronato M, Patel V, Darling S, Dearden L, Clague MJ, Urbé S, Coulson JM.

Cell Cycle. 2013 Jun 15;12(12):1964-77. doi: 10.4161/cc.25035. Epub 2013 May 20.


Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.

Ali N, Zhang L, Taylor S, Mironov A, Urbé S, Woodman P.

Curr Biol. 2013 Mar 18;23(6):453-61. doi: 10.1016/j.cub.2013.02.033. Epub 2013 Mar 7.

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