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Items: 1 to 20 of 82

1.

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.

Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J.

Nat Biotechnol. 2014 Apr;32(4):373-80. doi: 10.1038/nbt.2838. Epub 2014 Mar 23.

2.

12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash.

Sharma AM, Novalen M, Tanino T, Uetrecht JP.

Chem Res Toxicol. 2013 May 20;26(5):817-27. doi: 10.1021/tx400098z. Epub 2013 May 3.

PMID:
23590230
3.

A fresh look at the mechanism of isoniazid-induced hepatotoxicity.

Metushi IG, Cai P, Zhu X, Nakagawa T, Uetrecht JP.

Clin Pharmacol Ther. 2011 Jun;89(6):911-4. doi: 10.1038/clpt.2010.355. Epub 2011 Mar 16. Review. No abstract available.

PMID:
21412230
4.

Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats.

Zhu X, Li J, Liu F, Uetrecht JP.

Toxicol Sci. 2011 Apr;120(2):331-8. doi: 10.1093/toxsci/kfq392. Epub 2011 Jan 12.

PMID:
21227906
5.

Effect of clozapine on neutrophil kinetics in rabbits.

Iverson S, Kautiainen A, Ip J, Uetrecht JP.

Chem Res Toxicol. 2010 Jul 19;23(7):1184-91. doi: 10.1021/tx100035k.

PMID:
20553052
6.

The danger hypothesis applied to idiosyncratic drug reactions.

Li J, Uetrecht JP.

Handb Exp Pharmacol. 2010;(196):493-509. doi: 10.1007/978-3-642-00663-0_18. Review.

PMID:
20020274
7.

Nevirapine hypersensitivity.

Popovic M, Shenton JM, Chen J, Baban A, Tharmanathan T, Mannargudi B, Abdulla D, Uetrecht JP.

Handb Exp Pharmacol. 2010;(196):437-51. doi: 10.1007/978-3-642-00663-0_15. Review.

PMID:
20020271
8.

A study of the specificity of lymphocytes in nevirapine-induced skin rash.

Chen X, Tharmanathan T, Mannargudi B, Gou H, Uetrecht JP.

J Pharmacol Exp Ther. 2009 Dec;331(3):836-41. doi: 10.1124/jpet.109.157362. Epub 2009 Sep 4.

9.

D-penicillamine-induced autoimmunity: relationship to macrophage activation.

Li J, Uetrecht JP.

Chem Res Toxicol. 2009 Sep;22(9):1526-33. doi: 10.1021/tx900128p.

PMID:
19575532
10.

Covalent binding of penicillamine to macrophages: implications for penicillamine-induced autoimmunity.

Li J, Mannargudi B, Uetrecht JP.

Chem Res Toxicol. 2009 Jul;22(7):1277-84. doi: 10.1021/tx900087z.

PMID:
19462940
11.

Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis.

Pacitto SR, Uetrecht JP, Boutros PC, Popovic M.

J Immunotoxicol. 2007 Oct;4(4):253-66. doi: 10.1080/15476910701680020.

PMID:
18958736
12.

Investigation of the involvement of macrophages and T cells in D-penicillamine-induced autoimmunity in the Brown Norway rat.

Masson MJ, Teranishi M, Shenton JM, Uetrecht JP.

J Immunotoxicol. 2004 Apr;1(2):79-93. doi: 10.1080/15476910490496258.

PMID:
18958641
13.

Hepatic effects of duloxetine-II: spontaneous reports and epidemiology of hepatic events.

Wernicke J, Acharya N, Strombom I, Gahimer JL, D'Souza DN, DiPietro N, Uetrecht JP.

Curr Drug Saf. 2008 May;3(2):143-53. Review.

PMID:
18690992
14.

Hepatic effects of duloxetine-I: non-clinical and clinical trial data.

Wernicke J, Pangallo B, Wang F, Murray I, Henck JW, Knadler MP, D'Souza DN, Uetrecht JP.

Curr Drug Saf. 2008 May;3(2):132-42. Review. Erratum in: Curr Drug Saf. 2009 Jan;4(1):94.

PMID:
18690991
15.

Changes in gene expression induced by carbamazepine and phenytoin: testing the danger hypothesis.

Lu W, Li X, Uetrecht JP.

J Immunotoxicol. 2008 Apr;5(2):107-13. doi: 10.1080/15476910802085723.

PMID:
18569379
16.

Peroxidase-mediated bioactivation of hydroxylated metabolites of carbamazepine and phenytoin.

Lu W, Uetrecht JP.

Drug Metab Dispos. 2008 Aug;36(8):1624-36. doi: 10.1124/dmd.107.019554. Epub 2008 May 7.

17.

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.

Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS.

Drug Metab Dispos. 2008 Aug;36(8):1637-49. doi: 10.1124/dmd.107.019562. Epub 2008 May 7.

18.

Testing the hypothesis that vitamin C deficiency is a risk factor for clozapine-induced agranulocytosis using guinea pigs and ODS rats.

Ip J, Wilson JX, Uetrecht JP.

Chem Res Toxicol. 2008 Apr;21(4):869-73. doi: 10.1021/tx7004025. Epub 2008 Apr 2.

PMID:
18380445
19.

Testing the hypothesis that selenium deficiency is a risk factor for clozapine-induced agranulocytosis in rats.

Ip J, Uetrecht JP.

Chem Res Toxicol. 2008 Apr;21(4):874-8. doi: 10.1021/tx7004037. Epub 2008 Apr 2.

PMID:
18380444
20.

Possible bioactivation pathways of lamotrigine.

Lu W, Uetrecht JP.

Drug Metab Dispos. 2007 Jul;35(7):1050-6. Epub 2007 Apr 4.

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