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Items: 13

1.

Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis.

Blom S, Paavolainen L, Bychkov D, Turkki R, Mäki-Teeri P, Hemmes A, Välimäki K, Lundin J, Kallioniemi O, Pellinen T.

Sci Rep. 2017 Nov 14;7(1):15580. doi: 10.1038/s41598-017-15798-4.

2.

Antibody-supervised deep learning for quantification of tumor-infiltrating immune cells in hematoxylin and eosin stained breast cancer samples.

Turkki R, Linder N, Kovanen PE, Pellinen T, Lundin J.

J Pathol Inform. 2016 Sep 1;7:38. doi: 10.4103/2153-3539.189703. eCollection 2016. Erratum in: J Pathol Inform. 2016 Sep 28;7:41.

3.

Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers.

Ranki T, Pesonen S, Hemminki A, Partanen K, Kairemo K, Alanko T, Lundin J, Linder N, Turkki R, Ristimäki A, Jäger E, Karbach J, Wahle C, Kankainen M, Backman C, von Euler M, Haavisto E, Hakonen T, Heiskanen R, Jaderberg M, Juhila J, Priha P, Suoranta L, Vassilev L, Vuolanto A, Joensuu T.

J Immunother Cancer. 2016 Mar 15;4:17. doi: 10.1186/s40425-016-0121-5. eCollection 2016.

4.

Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner.

Holmström O, Linder N, Lundin M, Moilanen H, Suutala A, Turkki R, Joensuu H, Isola J, Diwan V, Lundin J.

PLoS One. 2015 Dec 14;10(12):e0144688. doi: 10.1371/journal.pone.0144688. eCollection 2015.

5.

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices.

Davies EJ, Dong M, Gutekunst M, Närhi K, van Zoggel HJ, Blom S, Nagaraj A, Metsalu T, Oswald E, Erkens-Schulze S, Delgado San Martin JA, Turkki R, Wedge SR, af Hällström TM, Schueler J, van Weerden WM, Verschuren EW, Barry ST, van der Kuip H, Hickman JA.

Sci Rep. 2015 Dec 9;5:17187. doi: 10.1038/srep17187.

6.

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus.

Taipale K, Liikanen I, Juhila J, Turkki R, Tähtinen S, Kankainen M, Vassilev L, Ristimäki A, Koski A, Kanerva A, Diaconu I, Cerullo V, Vähä-Koskela M, Oksanen M, Linder N, Joensuu T, Lundin J, Hemminki A.

Mol Ther. 2016 Feb;24(1):175-83. doi: 10.1038/mt.2015.143. Epub 2015 Aug 27.

7.

Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+ T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer.

Vassilev L, Ranki T, Joensuu T, Jäger E, Karbach J, Wahle C, Partanen K, Kairemo K, Alanko T, Turkki R, Linder N, Lundin J, Ristimäki A, Kankainen M, Hemminki A, Backman C, Dienel K, von Euler M, Haavisto E, Hakonen T, Juhila J, Jäderberg M, Priha P, Vuolanto A, Pesonen S.

Oncoimmunology. 2015 Apr 1;4(7):e1017702. eCollection 2015 Jul.

8.

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis.

Turkki R, Linder N, Holopainen T, Wang Y, Grote A, Lundin M, Alitalo K, Lundin J.

J Clin Pathol. 2015 Aug;68(8):614-21. doi: 10.1136/jclinpath-2015-202888. Epub 2015 May 28.

9.

Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+ T-cell response, prominent infiltration of CD8+ lymphocytes and Th1 type polarization.

Ranki T, Joensuu T, Jäger E, Karbach J, Wahle C, Kairemo K, Alanko T, Partanen K, Turkki R, Linder N, Lundin J, Ristimäki A, Kankainen M, Hemminki A, Backman C, Dienel K, von Euler M, Haavisto E, Hakonen T, Juhila J, Jaderberg M, Priha P, Vassilev L, Vuolanto A, Pesonen S.

Oncoimmunology. 2014 Dec 15;3(10):e958937. eCollection 2014 Nov.

10.

Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy.

Hemminki O, Parviainen S, Juhila J, Turkki R, Linder N, Lundin J, Kankainen M, Ristimäki A, Koski A, Liikanen I, Oksanen M, Nettelbeck DM, Kairemo K, Partanen K, Joensuu T, Kanerva A, Hemminki A.

Oncotarget. 2015 Feb 28;6(6):4467-81.

11.

T-cell subsets in peripheral blood and tumors of patients treated with oncolytic adenoviruses.

Taipale K, Liikanen I, Juhila J, Karioja-Kallio A, Oksanen M, Turkki R, Linder N, Lundin J, Ristimäki A, Kanerva A, Koski A, Joensuu T, Vähä-Koskela M, Hemminki A.

Mol Ther. 2015 May;23(5):964-973. doi: 10.1038/mt.2015.17. Epub 2015 Feb 6. Erratum in: Mol Ther. 2016 Jun;24(6):1159.

12.

A malaria diagnostic tool based on computer vision screening and visualization of Plasmodium falciparum candidate areas in digitized blood smears.

Linder N, Turkki R, Walliander M, Mårtensson A, Diwan V, Rahtu E, Pietikäinen M, Lundin M, Lundin J.

PLoS One. 2014 Aug 21;9(8):e104855. doi: 10.1371/journal.pone.0104855. eCollection 2014.

13.

Identification of tumor epithelium and stroma in tissue microarrays using texture analysis.

Linder N, Konsti J, Turkki R, Rahtu E, Lundin M, Nordling S, Haglund C, Ahonen T, Pietikäinen M, Lundin J.

Diagn Pathol. 2012 Mar 2;7:22. doi: 10.1186/1746-1596-7-22.

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