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Curr Issues Mol Biol. 2018;26:55-64. doi: 10.21775/cimb.026.055. Epub 2017 Sep 7.

CRISPR/Cas9-Mediated Immunity in Plants Against Pathogens.

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Department of Horticulture, Faculty of Agriculture and Natural Sciences, Abant Izzet Baysal University, Bolu, Turkey.
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Huazhong Agricultural University, Wuhan, The People's Republic of China.
Department of Plant Protection, Faculty of Agriculture and Natural Sciences, Abant Izzet Baysal University, Bolu, Turkey.
Department of Biology, Faculty of Science and Arts, Abant Izzet Baysal University, Bolu, Turkey.
Department of Biochemistry, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.


Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of pathogenicity and plant resistance against pathogen is important. The resistance against pathogens is regulated by three important phytohormones viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultaneously to produce super plants. Here we put forward our idea thatthe genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone biosynthesis genes will be better choice for resistance against pathogens.

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