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Items: 1 to 20 of 118


Rational Design of Cholesterol Derivative for Improved Stability of Paclitaxel Cationic Liposomes.

Monpara J, Kanthou C, Tozer GM, Vavia PR.

Pharm Res. 2018 Mar 8;35(4):90. doi: 10.1007/s11095-018-2367-8.


The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.

Shepherd J, Fisher M, Welford A, McDonald DM, Kanthou C, Tozer GM.

Oncotarget. 2017 Sep 21;8(56):95648-95661. doi: 10.18632/oncotarget.21172. eCollection 2017 Nov 10.


PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development.

Rumney RMH, Coffelt SB, Neale TA, Dhayade S, Tozer GM, Miller G.

PLoS One. 2017 Dec 8;12(12):e0188591. doi: 10.1371/journal.pone.0188591. eCollection 2017.


Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography.

Byers RA, Fisher M, Brown NJ, Tozer GM, Matcher SJ.

Biomed Opt Express. 2017 Sep 19;8(10):4551-4567. doi: 10.1364/BOE.8.004551. eCollection 2017 Oct 1.


Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma.

English WR, Lunt SJ, Fisher M, Lefley DV, Dhingra M, Lee YC, Bingham K, Hurrell JE, Lyons SK, Kanthou C, Tozer GM.

Cancer Res. 2017 May 15;77(10):2633-2646. doi: 10.1158/0008-5472.CAN-16-0255. Epub 2017 Apr 4.


Direct arterial injection of hyperpolarized 13 C-labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution.

Reynolds S, Metcalf S, Cochrane EJ, Collins RC, Jones S, Paley MNJ, Tozer GM.

Magn Reson Med. 2017 Dec;78(6):2116-2126. doi: 10.1002/mrm.26628. Epub 2017 Feb 12.


Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.


Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4.

Brown AW, Fisher M, Tozer GM, Kanthou C, Harrity JP.

J Med Chem. 2016 Oct 27;59(20):9473-9488. Epub 2016 Oct 7.


Longitudinal imaging of the ageing mouse.

Dall'Ara E, Boudiffa M, Taylor C, Schug D, Fiegle E, Kennerley AJ, Damianou C, Tozer GM, Kiessling F, Müller R.

Mech Ageing Dev. 2016 Dec;160:93-116. doi: 10.1016/j.mad.2016.08.001. Epub 2016 Aug 13. Review.


Quantitative Estimation of Tissue Blood Flow Rate.

Tozer GM, Prise VE, Cunningham VJ.

Methods Mol Biol. 2016;1430:265-81. doi: 10.1007/978-1-4939-3628-1_18.


Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.

Bluff JE, Reynolds S, Metcalf S, Alizadeh T, Kazan SM, Bucur A, Wholey EG, Bibby BA, Williams L, Paley MN, Tozer GM.

Radiother Oncol. 2015 Sep;116(3):392-9. doi: 10.1016/j.radonc.2015.03.011. Epub 2015 Mar 27.


Relaxation and exchange dynamics of hyperpolarized 129Xe in human blood.

Norquay G, Leung G, Stewart NJ, Tozer GM, Wolber J, Wild JM.

Magn Reson Med. 2015 Aug;74(2):303-11. doi: 10.1002/mrm.25417. Epub 2014 Aug 28.


Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics.

Kanthou C, Dachs GU, Lefley DV, Steele AJ, Coralli-Foxon C, Harris S, Greco O, Dos Santos SA, Reyes-Aldasoro CC, English WR, Tozer GM.

PLoS One. 2014 Aug 13;9(8):e104015. doi: 10.1371/journal.pone.0104015. eCollection 2014.


An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate.

Williams LJ, Mukherjee D, Fisher M, Reyes-Aldasoro CC, Akerman S, Kanthou C, Tozer GM.

Br J Pharmacol. 2014 Nov;171(21):4902-13. doi: 10.1111/bph.12817.


MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent.

Cole LM, Bluff JE, Carolan VA, Paley MN, Tozer GM, Clench MR.

Proteomics. 2014 Apr;14(7-8):890-903. doi: 10.1002/pmic.201300429.


A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range.

Reynolds S, Bucur A, Port M, Alizadeh T, Kazan SM, Tozer GM, Paley MN.

J Magn Reson. 2014 Feb;239:1-8. doi: 10.1016/j.jmr.2013.10.024. Epub 2013 Nov 22.


Recombinant " IMS TAG" proteins--a new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging.

Cole LM, Mahmoud K, Haywood-Small S, Tozer GM, Smith DP, Clench MR.

Rapid Commun Mass Spectrom. 2013 Nov 15;27(21):2355-62. doi: 10.1002/rcm.6693.


Influence of soluble or matrix-bound isoforms of vascular endothelial growth factor-A on tumor response to vascular-targeted strategies.

Akerman S, Fisher M, Daniel RA, Lefley D, Reyes-Aldasoro CC, Lunt SJ, Harris S, Bjorndahl M, Williams LJ, Evans H, Barber PR, Prise VE, Vojnovic B, Kanthou C, Tozer GM.

Int J Cancer. 2013 Dec 1;133(11):2563-76. doi: 10.1002/ijc.28281. Epub 2013 Jul 10.


Kinetic modeling of hyperpolarized (13)C pyruvate metabolism in tumors using a measured arterial input function.

Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN, Tozer GM.

Magn Reson Med. 2013 Oct;70(4):943-53. doi: 10.1002/mrm.24546. Epub 2012 Nov 20.


Online chromatic and scale-space microvessel-tracing analysis for transmitted light optical images.

Reyes-Aldasoro CC, Björndahl MA, Akerman S, Ibrahim J, Griffiths MK, Tozer GM.

Microvasc Res. 2012 Nov;84(3):330-9. doi: 10.1016/j.mvr.2012.09.002. Epub 2012 Sep 14.


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