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Items: 1 to 20 of 44


Characterization of IL-17AA and IL-17FF in rheumatoid arthritis and multiple sclerosis.

Schofield C, Fischer SK, Townsend MJ, Mosesova S, Peng K, Setiadi AF, Song A, Baruch A.

Bioanalysis. 2016 Nov;8(22):2317-2327.


Reducing the risk of failure: biomarker-guided trial design.

Townsend MJ, Arron JR.

Nat Rev Drug Discov. 2016 Aug;15(8):517-8. doi: 10.1038/nrd.2016.124. No abstract available.


The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.

Hung T, Pratt GA, Sundararaman B, Townsend MJ, Chaivorapol C, Bhangale T, Graham RR, Ortmann W, Criswell LA, Yeo GW, Behrens TW.

Science. 2015 Oct 23;350(6259):455-9. doi: 10.1126/science.aac7442.


Functionalized micro-capillary film for the rapid at-line analysis of IgG aggregates in a cell culture bioreactor.

Townsend MJ, Gruber DE, Kuiper M, Lazar RA, Field RP, Turner RE, Slater NK.

MAbs. 2015;7(5):812-9. doi: 10.1080/19420862.2015.1065365.


A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE).

Kalunian KC, Merrill JT, Maciuca R, McBride JM, Townsend MJ, Wei X, Davis JC Jr, Kennedy WP.

Ann Rheum Dis. 2016 Jan;75(1):196-202. doi: 10.1136/annrheumdis-2014-206090.


Ability of Interleukin-33- and Immune Complex-Triggered Activation of Human Mast Cells to Down-Regulate Monocyte-Mediated Immune Responses.

Rivellese F, Suurmond J, Habets K, Dorjée AL, Ramamoorthi N, Townsend MJ, de Paulis A, Marone G, Huizinga TW, Pitzalis C, Toes RE.

Arthritis Rheumatol. 2015 Sep;67(9):2343-53. doi: 10.1002/art.39192.


Stratified medicine in inflammatory disorders: From theory to practice.

Arron JR, Townsend MJ, Keir ME, Yaspan BL, Chan AC.

Clin Immunol. 2015 Nov;161(1):11-22. doi: 10.1016/j.clim.2015.04.006. Review.


Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE.

Kennedy WP, Maciuca R, Wolslegel K, Tew W, Abbas AR, Chaivorapol C, Morimoto A, McBride JM, Brunetta P, Richardson BC, Davis JC Jr, Behrens TW, Townsend MJ.

Lupus Sci Med. 2015 Mar 28;2(1):e000080. doi: 10.1136/lupus-2014-000080.


Molecular and cellular heterogeneity in the Rheumatoid Arthritis synovium: clinical correlates of synovitis.

Townsend MJ.

Best Pract Res Clin Rheumatol. 2014 Aug;28(4):539-49. doi: 10.1016/j.berh.2014.10.024. Review.


Modular analysis of peripheral blood gene expression in rheumatoid arthritis captures reproducible gene expression changes in tumor necrosis factor responders.

Oswald M, Curran ME, Lamberth SL, Townsend RM, Hamilton JD, Chernoff DN, Carulli J, Townsend MJ, Weinblatt ME, Kern M, Pond CM, Lee A, Gregersen PK.

Arthritis Rheumatol. 2015 Feb;67(2):344-51. doi: 10.1002/art.38947.


Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study).

Kennedy WP, Simon JA, Offutt C, Horn P, Herman A, Townsend MJ, Tang MT, Grogan JL, Hsieh F, Davis JC.

Arthritis Res Ther. 2014 Oct 30;16(5):467. doi: 10.1186/s13075-014-0467-3.


Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

Dennis G Jr, Holweg CT, Kummerfeld SK, Choy DF, Setiadi AF, Hackney JA, Haverty PM, Gilbert H, Lin WY, Diehl L, Fischer S, Song A, Musselman D, Klearman M, Gabay C, Kavanaugh A, Endres J, Fox DA, Martin F, Townsend MJ.

Arthritis Res Ther. 2014;16(2):R90.


Evolution of modular intraflagellar transport from a coatomer-like progenitor.

van Dam TJ, Townsend MJ, Turk M, Schlessinger A, Sali A, Field MC, Huynen MA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6943-8. doi: 10.1073/pnas.1221011110.


Lentivirus capture directly from cell culture with Q-functionalised microcapillary film chromatography.

Darton NJ, Darling D, Townsend MJ, McNally DJ, Farzaneh F, Slater NK.

J Chromatogr A. 2012 Aug 17;1251:236-9. doi: 10.1016/j.chroma.2012.06.072.


Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab.

Hogan VE, Holweg CT, Choy DF, Kummerfeld SK, Hackney JA, Teng YK, Townsend MJ, van Laar JM.

Ann Rheum Dis. 2012 Nov;71(11):1888-94. doi: 10.1136/annrheumdis-2011-201115.


Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment.

Lal P, Su Z, Holweg CT, Silverman GJ, Schwartzman S, Kelman A, Read S, Spaniolo G, Monroe JG, Behrens TW, Townsend MJ.

Arthritis Rheum. 2011 Dec;63(12):3681-91. doi: 10.1002/art.30596.


MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments.

Scheerens H, Su Z, Irving B, Townsend MJ, Zheng Y, Stefanich E, Chindalore V, Bingham CO 3rd, Davis JC Jr.

Arthritis Res Ther. 2011;13(5):R177. doi: 10.1186/ar3502.


A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis.

Owczarczyk K, Lal P, Abbas AR, Wolslegel K, Holweg CT, Dummer W, Kelman A, Brunetta P, Lewin-Koh N, Sorani M, Leong D, Fielder P, Yocum D, Ho C, Ortmann W, Townsend MJ, Behrens TW.

Sci Transl Med. 2011 Sep 21;3(101):101ra92. doi: 10.1126/scitranslmed.3002432.


Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus.

Morimoto AM, Flesher DT, Yang J, Wolslegel K, Wang X, Brady A, Abbas AR, Quarmby V, Wakshull E, Richardson B, Townsend MJ, Behrens TW.

Arthritis Rheum. 2011 Aug;63(8):2407-15. doi: 10.1002/art.30399.


Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF.

DeForge LE, Loyet KM, Delarosa D, Chinn J, Zamanian F, Chuntharapai A, Lee J, Hass P, Wei N, Townsend MJ, Wang J, Wong WL.

J Immunol Methods. 2010 Oct 31;362(1-2):70-81. doi: 10.1016/j.jim.2010.09.004.

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