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Items: 1 to 20 of 76

1.

Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.

Divakaran A, Talluri SK, Ayoub AM, Mishra N, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schönbrunn E, Harki DA, Pomerantz WCK.

J Med Chem. 2018 Sep 25. doi: 10.1021/acs.jmedchem.8b01248. [Epub ahead of print]

PMID:
30253095
2.

Palladium-catalyzed salt-free double decarboxylative aryl allylation.

Daley RA, Topczewski JJ.

Org Biomol Chem. 2018 Aug 23. doi: 10.1039/c8ob01806e. [Epub ahead of print]

PMID:
30137100
3.

Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition.

Hu B, Gao Y, Davies L, Woo S, Topczewski J, Jessen JR, Lin F.

Development. 2018 Aug 28;145(17). pii: dev163303. doi: 10.1242/dev.163303.

PMID:
30082271
4.

Evidence for a Sigmatropic and an Ionic Pathway in the Winstein Rearrangement.

Ott AA, Packard MH, Ortuño MA, Johnson A, Suding VP, Cramer CJ, Topczewski JJ.

J Org Chem. 2018 Aug 3;83(15):8214-8224. doi: 10.1021/acs.joc.8b00961. Epub 2018 Jun 14.

PMID:
29870252
5.

Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development.

Pogoda HM, Riedl-Quinkertz I, Löhr H, Waxman JS, Dale RM, Topczewski J, Schulte-Merker S, Hammerschmidt M.

Development. 2018 May 8;145(9). pii: dev159418. doi: 10.1242/dev.159418.

PMID:
29650589
6.

Regiocontrolled Wacker Oxidation of Cinnamyl Azides.

Carlson AS, Calcanas C, Brunner RM, Topczewski JJ.

Org Lett. 2018 Mar 16;20(6):1604-1607. doi: 10.1021/acs.orglett.8b00344. Epub 2018 Mar 2.

PMID:
29498865
7.

Stereoselective Dynamic Cyclization of Allylic Azides: Synthesis of Tetralins, Chromanes, and Tetrahydroquinolines.

Porter MR, Shaker RM, Calcanas C, Topczewski JJ.

J Am Chem Soc. 2018 Jan 31;140(4):1211-1214. doi: 10.1021/jacs.7b11299. Epub 2018 Jan 10.

PMID:
29303567
8.

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).

Kell MJ, Riccio RE, Baumgartner EA, Compton ZJ, Pecorin PJ, Mitchell TA, Topczewski J, LeClair EE.

PLoS One. 2018 Jan 2;13(1):e0190353. doi: 10.1371/journal.pone.0190353. eCollection 2018.

9.

Why is Aged Acetylcholinesterase So Difficult to Reactivate?

Quinn DM, Topczewski J, Yasapala N, Lodge A.

Molecules. 2017 Sep 4;22(9). pii: E1464. doi: 10.3390/molecules22091464. Review.

10.

Dynamic Kinetic Resolution of Allylic Azides via Asymmetric Dihydroxylation.

Ott AA, Goshey CS, Topczewski JJ.

J Am Chem Soc. 2017 Jun 14;139(23):7737-7740. doi: 10.1021/jacs.7b04203. Epub 2017 Jun 5.

PMID:
28574252
11.

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.

Sredni ST, Suzuki M, Yang JP, Topczewski J, Bailey AW, Gokirmak T, Gross JN, de Andrade A, Kondo A, Piper DR, Tomita T.

Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26551. Epub 2017 Apr 11.

PMID:
28398638
12.

Multi-Shell Nano-CarboScavengers for Petroleum Spill Remediation.

Daza EA, Misra SK, Scott J, Tripathi I, Promisel C, Sharma BK, Topczewski J, Chaudhuri S, Pan D.

Sci Rep. 2017 Feb 3;7:41880. doi: 10.1038/srep41880.

13.

Palladium-catalysed transannular C-H functionalization of alicyclic amines.

Topczewski JJ, Cabrera PJ, Saper NI, Sanford MS.

Nature. 2016 Mar 10;531(7593):220-224. doi: 10.1038/nature16957. Epub 2016 Feb 17.

14.

A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.

Sisson BE, Dale RM, Mui SR, Topczewska JM, Topczewski J.

Mech Dev. 2015 Nov;138 Pt 3:279-90. doi: 10.1016/j.mod.2015.10.001. Epub 2015 Oct 14.

15.

Development of quantitative structure activity relationships for the binding affinity of methoxypyridinium cations for human acetylcholinesterase.

Morrill JA, Topczewski JJ, Lodge AM, Yasapala N, Quinn DM.

J Mol Graph Model. 2015 Nov;62:181-189. doi: 10.1016/j.jmgm.2015.09.016. Epub 2015 Sep 30.

PMID:
26454505
16.

Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.

Cvjetkovic N, Maili L, Weymouth KS, Hashmi SS, Mulliken JB, Topczewski J, Letra A, Yuan Q, Blanton SH, Swindell EC, Hecht JT.

Mol Genet Genomic Med. 2015 Sep;3(5):440-51. doi: 10.1002/mgg3.155. Epub 2015 May 7.

17.

Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates.

Zhang Q, Stockdale DP, Mixdorf JC, Topczewski JJ, Nguyen HM.

J Am Chem Soc. 2015 Sep 23;137(37):11912-5. doi: 10.1021/jacs.5b07492. Epub 2015 Sep 10.

PMID:
26348569
18.

Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.

Miller N, Feng Z, Edens BM, Yang B, Shi H, Sze CC, Hong BT, Su SC, Cantu JA, Topczewski J, Crawford TO, Ko CP, Sumner CJ, Ma L, Ma YC.

J Neurosci. 2015 Apr 15;35(15):6038-50. doi: 10.1523/JNEUROSCI.3716-14.2015.

19.

Comparison of different numerical treatments for x-ray phase tomography of soft tissue from differential phase projections.

Pelliccia D, Vaz R, Svalbe I, Morgan KS, Marathe S, Xiao X, Assoufid L, Anderson RA, Topczewski J, Bryson-Richardson RJ.

Phys Med Biol. 2015 Apr 21;60(8):3065-80. doi: 10.1088/0031-9155/60/8/3065. Epub 2015 Mar 24.

PMID:
25802946
20.

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