Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 175

1.

DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease.

Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK.

Genes Dev. 2018 Jul 1;32(13-14):944-952. doi: 10.1101/gad.314658.118. Epub 2018 Jun 26.

PMID:
29945887
2.

Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.

Zhang J, Wang Z, Zhang S, Chen Y, Xiong X, Li X, Tonks NK, Fan G.

Cell Signal. 2018 Oct;50:100-110. doi: 10.1016/j.cellsig.2018.06.006. Epub 2018 Jun 18.

PMID:
29920310
3.

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.

Krishnan N, Bonham CA, Rus IA, Shrestha OK, Gauss CM, Haque A, Tocilj A, Joshua-Tor L, Tonks NK.

Nat Commun. 2018 Jan 18;9(1):283. doi: 10.1038/s41467-017-02252-2.

4.

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

Krishnan N, Konidaris KF, Gasser G, Tonks NK.

J Biol Chem. 2018 Feb 2;293(5):1517-1525. doi: 10.1074/jbc.C117.819110. Epub 2017 Dec 7.

PMID:
29217773
5.

Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.

Zhang S, Fan G, Hao Y, Hammell M, Wilkinson JE, Tonks NK.

Genes Dev. 2017 Oct 1;31(19):1939-1957. doi: 10.1101/gad.304261.117. Epub 2017 Oct 24.

6.

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD.

Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11.

7.

HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer.

Fan G, Zhang S, Gao Y, Greer PA, Tonks NK.

Genes Dev. 2016 Jul 1;30(13):1542-57. doi: 10.1101/gad.284166.116.

8.

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK.

J Clin Invest. 2015 Aug 3;125(8):3163-77. doi: 10.1172/JCI80323. Epub 2015 Jul 27.

9.

Anxious moments for the protein tyrosine phosphatase PTP1B.

Krishnan N, Tonks NK.

Trends Neurosci. 2015 Aug;38(8):462-5. doi: 10.1016/j.tins.2015.06.006. Epub 2015 Jul 9.

10.

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.

Fan G, Aleem S, Yang M, Miller WT, Tonks NK.

J Biol Chem. 2015 Jun 26;290(26):15934-47. doi: 10.1074/jbc.M115.651703. Epub 2015 Apr 20.

11.

PTP1B: mediating ROS signaling to silence genes.

Boivin B, Tonks NK.

Mol Cell Oncol. 2015 Feb 26;2(2):e975633. doi: 10.4161/23723556.2014.975633. eCollection 2015 Apr-Jun.

12.

A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.

Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK.

J Biol Chem. 2015 Apr 10;290(15):9646-59. doi: 10.1074/jbc.M114.627968. Epub 2015 Feb 13.

13.

A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines.

Fan G, Wrzeszczynski KO, Fu C, Su G, Pappin DJ, Lucito R, Tonks NK.

Biochem J. 2015 Feb 1;465(3):433-42. doi: 10.1042/BJ20141087.

14.

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.

Chaudhary F, Lucito R, Tonks NK.

Biochem J. 2015 Jan 1;465(1):89-101. doi: 10.1042/BJ20140573.

15.

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, Tonks NK.

Mol Cell. 2014 Sep 4;55(5):782-90. doi: 10.1016/j.molcel.2014.07.018. Epub 2014 Aug 28.

16.

A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.

17.

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1.

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK.

FEBS J. 2014 Aug;281(16):3545-58. doi: 10.1111/febs.12898. Epub 2014 Jul 23.

18.

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.

Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK.

Nat Chem Biol. 2014 Jul;10(7):558-66. doi: 10.1038/nchembio.1528. Epub 2014 May 20.

19.

Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.

Mondol AS, Tonks NK, Kamata T.

Free Radic Biol Med. 2014 Feb;67:285-91. doi: 10.1016/j.freeradbiomed.2013.11.005. Epub 2013 Nov 13.

PMID:
24239742
20.

Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.

Boivin B, Chaudhary F, Dickinson BC, Haque A, Pero SC, Chang CJ, Tonks NK.

J Biol Chem. 2013 Dec 27;288(52):36926-35. doi: 10.1074/jbc.M113.527564. Epub 2013 Nov 11.

Supplemental Content

Loading ...
Support Center