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Items: 1 to 20 of 143


Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

Iuliano JN, Gil AA, Laptenok SP, Hall CR, Tolentino Collado J, Lukacs A, Hag Ahmed SA, Abyad J, Daryaee T, Greetham GM, Sazanovich IV, Illarionov B, Bacher A, Fischer M, Towrie M, French JB, Meech SR, Tonge PJ.

Biochemistry. 2018 Feb 6;57(5):620-630. doi: 10.1021/acs.biochem.7b01040. Epub 2018 Jan 4.


Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues.

Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon GE, Brust R, Greetham GM, Towrie M, French JB, Meech SR, Tonge PJ.

J Am Chem Soc. 2017 Oct 18;139(41):14638-14648. doi: 10.1021/jacs.7b07849. Epub 2017 Oct 5.


CNS Anticancer Drug Discovery and Development: 2016 conference insights.

Levin VA, Abrey LE, Heffron TP, Tonge PJ, Dar AC, Weiss WA, Gallo JM.

CNS Oncol. 2017 Jul 18. doi: 10.2217/cns-2017-0014. [Epub ahead of print]


Drug-Target Kinetics in Drug Discovery.

Tonge PJ.

ACS Chem Neurosci. 2018 Jan 17;9(1):29-39. doi: 10.1021/acschemneuro.7b00185. Epub 2017 Jul 14.


A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.

Daryaee F, Zhang Z, Gogarty KR, Li Y, Merino J, Fisher SL, Tonge PJ.

Chem Sci. 2017 May 1;8(5):3434-3443. doi: 10.1039/c6sc03306g. Epub 2017 Mar 14.


Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ.

Biochemistry. 2017 Apr 4;56(13):1865-1878. doi: 10.1021/acs.biochem.6b01048. Epub 2017 Mar 21.


The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography.

Zhang Z, Ordonez AA, Smith-Jones P, Wang H, Gogarty KR, Daryaee F, Bambarger LE, Chang YS, Jain SK, Tonge PJ.

PLoS One. 2017 Feb 2;12(2):e0170871. doi: 10.1371/journal.pone.0170871. eCollection 2017.


Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.

Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ.

J Am Chem Soc. 2017 Mar 8;139(9):3417-3429. doi: 10.1021/jacs.6b11148. Epub 2017 Feb 22.


Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain.

Gil AA, Laptenok SP, French JB, Iuliano JN, Lukacs A, Hall CR, Sazanovich IV, Greetham GM, Bacher A, Illarionov B, Fischer M, Tonge PJ, Meech SR.

J Phys Chem B. 2017 Feb 9;121(5):1010-1019. doi: 10.1021/acs.jpcb.7b00088. Epub 2017 Jan 25.


Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics.

Evans CE, Matarlo JS, Tonge PJ, Tan DS.

Org Lett. 2016 Dec 16;18(24):6384-6387. Epub 2016 Dec 1.


Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

Knudson SE, Cummings JE, Bommineni GR, Pan P, Tonge PJ, Slayden RA.

Tuberculosis (Edinb). 2016 Dec;101:8-14. doi: 10.1016/ Epub 2016 Aug 3.


Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

Ghiano DG, de la Iglesia A, Liu N, Tonge PJ, Morbidoni HR, Labadie GR.

Eur J Med Chem. 2017 Jan 5;125:842-852. doi: 10.1016/j.ejmech.2016.09.086. Epub 2016 Sep 28.


Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.

Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ.

Chem Sci. 2016 Sep 1;7(9):5945-5954. Epub 2016 May 25.


A Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis Pathway.

Matarlo JS, Lu Y, Daryaee F, Daryaee T, Ruzsicska B, Walker SG, Tonge PJ.

ACS Infect Dis. 2016 May 13;2(5):329-340. Epub 2016 Mar 7.


Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ.

J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. Epub 2016 May 24.


Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Neckles C, Pschibul A, Lai CT, Hirschbeck M, Kuper J, Davoodi S, Zou J, Liu N, Pan P, Shah S, Daryaee F, Bommineni GR, Lai C, Simmerling C, Kisker C, Tonge PJ.

Biochemistry. 2016 May 31;55(21):2992-3006. doi: 10.1021/acs.biochem.5b01301. Epub 2016 May 17.


Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions.

Gil A, Haigney A, Laptenok SP, Brust R, Lukacs A, Iuliano J, Jeng J, Melief E, Zhao RK, Yoon E, Clark I, Towrie M, Greetham GM, Ng A, Truglio J, French J, Meech SR, Tonge PJ.

J Am Chem Soc. 2016 Jan 27;138(3):926-935. doi: 10.1021/jacs.5b11115. Epub 2016 Jan 15.


Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming.

Torres A, Luke JD, Kullas AL, Kapilashrami K, Botbol Y, Koller A, Tonge PJ, Chen EI, Macian F, van der Velden AW.

J Leukoc Biol. 2016 Feb;99(2):387-98. doi: 10.1189/jlb.4A0615-252R. Epub 2015 Oct 23.


CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC.

Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169.


Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ.

Biochemistry. 2015 Oct 27;54(42):6514-6524. doi: 10.1021/acs.biochem.5b00966. Epub 2015 Oct 15.

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