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J Med Chem. 2011 Jun 9;54(11):3982-6. doi: 10.1021/jm200272h. Epub 2011 May 16.

Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: alleviating drug-drug interactions through use of PubChem data and comparative molecular field analysis guided synthesis.

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1
Elara Pharmaceuticals GmbH , Boxbergring 107, 69127 Heidelberg, Germany.

Abstract

Inhibitors of hypoxia-inducible factor 1 (HIF-1) represent promising anticancer therapeutics. We have identified a series of potent toluidinesulfonamide HIF-1 inhibitors. However, the series was threatened by a potential liability to inhibit CYP2C9 which could cause dangerous drug-drug interactions when being coadministered with other drugs. We used structure-activity data from the PubChem database to develop a topomer CoMFA model that guided the design of novel sulfonamides with high selectivity for HIF-1 over CYP2C9 inhibition.

PMID:
21574568
DOI:
10.1021/jm200272h
[Indexed for MEDLINE]

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