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Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD.

Hum Mol Genet. 2018 Apr 12. doi: 10.1093/hmg/ddy128. [Epub ahead of print]


Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K.

J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.


Histologic processing artifacts and inter-pathologist variation in measurement of inked margins of canine mast cell tumors.

Kiser PK, Löhr CV, Meritet D, Spagnoli ST, Milovancev M, Russell DS.

J Vet Diagn Invest. 2018 Feb 1:1040638718757582. doi: 10.1177/1040638718757582. [Epub ahead of print]


A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K.

J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.


Long-term direct visualization of passively transferred fluorophore-conjugated antibodies.

Schneider JR, Carias AM, Bastian AR, Cianci GC, Kiser PF, Veazey RS, Hope TJ.

J Immunol Methods. 2017 Nov;450:66-72. doi: 10.1016/j.jim.2017.07.009. Epub 2017 Aug 2.


A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates.

Su JT, Teller RS, Srinivasan P, Zhang J, Martin A, Sung S, Smith JM, Kiser PF.

Pharm Res. 2017 Oct;34(10):2163-2171. doi: 10.1007/s11095-017-2224-1. Epub 2017 Aug 2.


Repeated administration of high-dose depot medroxyprogesterone acetate does not alter SHIVSF162p3 viral kinetics and tenofovir pharmacokinetics when delivered via intravaginal rings.

Srinivasan P, Zhang J, Dinh CT, Teller RS, McNicholl JM, Kiser PF, Herold BC, Smith JM.

J Med Primatol. 2017 Aug;46(4):129-136. doi: 10.1111/jmp.12299.


Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M.

ACS Chem Biol. 2017 Sep 15;12(9):2296-2304. doi: 10.1021/acschembio.7b00336. Epub 2017 Jul 26.


Reappraisal of dioxygen binding in NOV1 crystal structures.

Kiser PD.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6027-E6028. doi: 10.1073/pnas.1706550114. Epub 2017 Jul 5. No abstract available.


Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.

Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD.

Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.


Rational Tuning of Visual Cycle Modulator Pharmacodynamics.

Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K.

J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.


Lymphoma Classification in Goats.

Kiser PK, Löhr CV.

Vet Pathol. 2017 Jul;54(4):611-619. doi: 10.1177/0300985817699859. Epub 2017 Apr 6.


Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.


Retinoids and Retinal Diseases.

Kiser PD, Palczewski K.

Annu Rev Vis Sci. 2016 Oct;2:197-234. Epub 2016 Jul 18. Review.


Eyes on systems pharmacology.

Chen Y, Kern TS, Kiser PD, Palczewski K.

Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5. No abstract available.


Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men.

Greene GJ, Swann G, Fought AJ, Carballo-Diéguez A, Hope TJ, Kiser PF, Mustanski B, D'Aquila RT.

AIDS Behav. 2017 May;21(5):1336-1349. doi: 10.1007/s10461-016-1565-9.


Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract.

Carias AM, Allen SA, Fought AJ, Kotnik Halavaty K, Anderson MR, Jimenez ML, McRaven MD, Gioia CJ, Henning TR, Kersh EN, Smith JM, Pereira LE, Butler K, McNicholl SJ, Hendry RM, Kiser PF, Veazey RS, Hope TJ.

PLoS Pathog. 2016 Sep 22;12(9):e1005885. doi: 10.1371/journal.ppat.1005885. eCollection 2016 Sep.


Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K.

Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.


Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD.

J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.


Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage.

Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y.

J Biol Chem. 2016 Jun 17;291(25):12951-9. doi: 10.1074/jbc.M115.713248. Epub 2016 Apr 18.

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