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Curr Opin Immunol. 2009 Apr;21(2):140-5. doi: 10.1016/j.coi.2009.02.008. Epub 2009 Mar 25.

Thymic maturation determines gammadelta T cell function, but not their antigen specificities.

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1
The Department of Microbiology and Immunology, Stanford University, Beckman B255, Stanford, CA 94305, USA.

Abstract

gammadelta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFNgamma, whereas ligand-naïve gammadelta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.

PMID:
19321327
PMCID:
PMC2697822
DOI:
10.1016/j.coi.2009.02.008
[Indexed for MEDLINE]
Free PMC Article
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